WormBase Tree Display for Gene: WBGene00016392

WBGene00016392 SMap: S_parent: Sequence: C34B2
  Identity: Version: 2
    Name: CGC_name: sdha-2 Paper_evidence: WBPaper00005928
            WBPaper00006068
          Person_evidence: WBPerson4834
            WBPerson4867
      Sequence_name: C34B2.7
      Molecular_name: C34B2.7
        C34B2.7.1
        CE16895
      Other_name: CELE_C34B2.7 Accession_evidence: NDB BX284601
      Public_name: sdha-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 04 May 2006 14:27:47 WBPerson2970 Name_change: CGC_name: sdha-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sdha
    Allele (26)
    RNASeq_FPKM (74)
    GO_annotation (17)
    Contained_in_operon: CEOP1636
    Ortholog (45)
    Paralog: WBGene00015391 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018610 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: sdha-2 encodes one of two C. elegans flavoprotein subunits of the mitochondrial succinate dehydrogenase complex (Complex II). Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Oct 2011 00:00:00
      Automated_description: Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone). Human ortholog(s) of this gene implicated in several diseases, including Leigh disease; dilated cardiomyopathy 1GG; and mitochondrial complex II deficiency. Is an ortholog of human SDHA (succinate dehydrogenase complex flavoprotein subunit A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060537 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10680)
      DOID:0110435 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10680)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10680)
      DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10680)
      DOID:3652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10680)
      DOID:0050773 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10680)
  Molecular_info: Corresponding_CDS: C34B2.7
    Corresponding_transcript: C34B2.7.1
    Other_sequence (30)
    Associated_feature: WBsf649592
      WBsf663831
  Experimental_info: RNAi_result (22)
    Expr_pattern: Expr1019236
      Expr1037021
      Expr1145844
      Expr2015663
      Expr2033896
    Drives_construct: WBCnstr00028108
    Construct_product: WBCnstr00028108
    Microarray_results (21)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_upregulated_cDNA_24h
      WBPaper00037047:insoluble_protein
      WBPaper00037086:biotin_regulated
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037963:ife-1(ok1978)_downregulated
      WBPaper00038289:oocyte_protein
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040446:insoluble_protein
      WBPaper00040965:lipid-droplet_associated_protein
      WBPaper00040965:top50_lipid-droplet_associated_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_upregulated_Day5
      WBPaper00044746:aging_upregulated_HeatShock
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00045774:clk-1_upregulated_CoQ10_independent
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049954:BPS_downregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050193:lsm-1(tm3585)_upregulated_L3
      WBPaper00050193:met-2(n4256)set-25(n5021)_upregulated_L1
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050522:mafr-1(tm6082)_downregulated
      WBPaper00050599:nicotine(0.01mM)_upregulated
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
      WBPaper00056826:hmc_biased
      WBPaper00056900:TOFU-6_interacting
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-1(or286)_downregulated
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058948:PA14_upregulated
      WBPaper00059605:MUT-16_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_downregulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_L1
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061045:Y56A3A.22(cck200)_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:Germline
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:T22D1.5-inx-14
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_upregulated_neuron
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064080:miR-2_miRNA_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064403:Heat-killed-E.Coli_upregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_1
      WBPaper00025032:cluster_177
      WBPaper00025032:PAL-1_target_genes
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027342:alpha-Synuclein(WT)_upregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_5
      WBPaper00034739:TreatmentAffectedGenes
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_H
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00049538:atfs-1(et18)_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:Cluster_F
      [cgc6390]:intrinsic
    Interaction (175)
  Map_info: Map: I Position: 5.06063 Error: 0.000126
    Positive: Positive_clone: C34B2 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene