WormBase Tree Display for Gene: WBGene00016313

WBGene00016313 SMap: S_parent: Sequence: C32D5
  Identity: Version: 2
    Name: CGC_name: set-4 Person_evidence: WBPerson1730
            WBPerson268
            WBPerson632
      Sequence_name: C32D5.5
      Molecular_name: C32D5.5
        C32D5.5.1
        CE01845
      Other_name: tag-337 Person_evidence: WBPerson201
        CELE_C32D5.5 Accession_evidence: NDB BX284602
      Public_name: set-4
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 03 May 2007 10:33:07 WBPerson2970 Name_change: CGC_name: set-4
                Other_name: tag-337
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: set
    Allele (24)
    Strain: WBStrain00027495
      WBStrain00036235
      WBStrain00050682
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (38)
    Structured_description: Concise_description: set-4 encodes a putative histone H4 lysine-20 methyltransferase; SET-4 is orthologous to Drosophila SUV4-20, and to human SUV420H1 (OMIM:610881) and SUV420H2; set-4(RNAi) animals exhibit an extended adult fertile worm lifespan. Paper_evidence: WBPaper00005599
            WBPaper00030864
            WBPaper00031080
          Curator_confirmed: WBPerson567
          Date_last_updated: 11 Oct 2007 00:00:00
      Automated_description: Predicted to enable histone H4K20me methyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in chromosome and nucleus. Expressed in several structures, including hypodermis and muscle cell. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 51. Is an ortholog of human KMT5B (lysine methyltransferase 5B) and KMT5C (lysine methyltransferase 5C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080232 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:24283)
  Molecular_info: Corresponding_CDS: C32D5.5
    Corresponding_transcript: C32D5.5.1
    Other_sequence (14)
    Associated_feature: WBsf650129
      WBsf650130
      WBsf665596
      WBsf988134
      WBsf1012362
      WBsf223155
      WBsf223156
  Experimental_info: RNAi_result: WBRNAi00041670 Inferred_automatically: RNAi_primary
      WBRNAi00011480 Inferred_automatically: RNAi_primary
      WBRNAi00029415 Inferred_automatically: RNAi_primary
      WBRNAi00091986 Inferred_automatically: RNAi_primary
      WBRNAi00113446 Inferred_automatically: RNAi_primary
      WBRNAi00091992 Inferred_automatically: RNAi_primary
      WBRNAi00007949 Inferred_automatically: RNAi_primary
      WBRNAi00091991 Inferred_automatically: RNAi_primary
      WBRNAi00091514 Inferred_automatically: RNAi_primary
      WBRNAi00091988 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr13301
      Expr14355
      Expr1010500
      Expr1036978
      Expr1145695
      Expr2015780
      Expr2034013
    Drives_construct: WBCnstr00028168
      WBCnstr00039182
    Construct_product: WBCnstr00028168
    Regulate_expr_cluster: WBPaper00050801:SET-4_dauer_regulome
    Antibody: WBAntibody00002748
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_downregulated_L1_SMARTseq
      WBPaper00055648:germline_expressed
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061274:hypergravity_10xg_upregulated
      WBPaper00061274:microgravity_upregulated
      WBPaper00061340:AMso_parent
      WBPaper00061527:cyy-1_3136-hcf-1_2478
      WBPaper00061527:kle-2_4298-vrk-1
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065158:AFD_depleted
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_2
      WBPaper00025032:cluster_13
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_3
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037611:RNP-8-associated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_13
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_E
      [cgc6390]:oogenesis-enriched
    Interaction (35)
  Map_info: Map: II Position: -0.381269 Error: 0.000183
    Positive: Positive_clone: C32D5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5272
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene