WormBase Tree Display for Gene: WBGene00016283

WBGene00016283 SMap: S_parent: Sequence: C31B8
  Identity: Version: 2
    Name: CGC_name: zmp-3 Paper_evidence: WBPaper00036427
          Person_evidence: WBPerson345
      Sequence_name: C31B8.8
      Molecular_name: C31B8.8
        C31B8.8.1
        CE26674
      Other_name: CELE_C31B8.8 Accession_evidence: NDB BX284605
      Public_name: zmp-3
    DB_info: Database: AceView gene 5D384
        WormQTL gene WBGene00016283
        WormFlux gene WBGene00016283
        NDB locus_tag CELE_C31B8.8
        Panther gene CAEEL|WormBase=WBGene00016283|UniProtKB=G5EBU3
          family PTHR10201
        NCBI gene 178748
        RefSeq protein NM_071389.6
        KEGG KEGG_id 3.4.24.-
        NemaPath KEGG_id 3.4.24.-
        SwissProt UniProtAcc G5EBU3
        UniProt_GCRP UniProtAcc G5EBU3
        OMIM gene 120353
            600108
            604629
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:57 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 04 Jan 2016 15:29:00 WBPerson2970 Name_change: CGC_name: zmp-3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: zmp
    Allele (172)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (73)
    Paralog: WBGene00006987 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010423 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00010524 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012185 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012364 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019212 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020646 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00194737 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Enables metallopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to be located in extracellular space. Expressed in anchor cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); and reproductive organ cancer (multiple). Is an ortholog of several human genes including MMP1 (matrix metallopeptidase 1); MMP3 (matrix metallopeptidase 3); and MMP8 (matrix metallopeptidase 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:5517 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:6000 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:2349 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7158,HGNC:7159,HGNC:7173)
      DOID:8472 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:4362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7159)
      DOID:0080600 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7175)
      DOID:11984 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:5844 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:1070 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:0080933 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:8805 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:9074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:2921 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7173)
      DOID:4250 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7173)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:799 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:14323 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7158)
      DOID:1245 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7159)
      DOID:418 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:3407 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7175)
      DOID:2377 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7158)
      DOID:10964 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:8923 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:0060903 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:8398 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7159,HGNC:7173,HGNC:7175)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173,HGNC:7175)
      DOID:7693 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7158,HGNC:7159,HGNC:7175)
      DOID:2378 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7165)
      DOID:9008 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:332 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:14004 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7158,HGNC:7175)
      DOID:0080030 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7159)
      DOID:0060224 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:83 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7173)
      DOID:13001 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:9351 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7156,HGNC:7173)
      DOID:4467 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7158)
      DOID:10983 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7173)
      DOID:898 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7175)
      DOID:12894 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7173)
      DOID:2320 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:0050156 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173)
      DOID:3362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7158)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7159)
      DOID:4914 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7158,HGNC:7173)
      DOID:4001 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7159)
      DOID:1936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:1712 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:824 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:7148 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7173,HGNC:7175)
      DOID:2508 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7173)
      DOID:0050855 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:10941 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7158)
      DOID:10588 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7156)
      DOID:0110060 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7167)
      DOID:2871 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7175)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7159)
      DOID:3008 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7159)
      DOID:13714 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7159)
      DOID:4959 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:13641 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:783 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7156,HGNC:7173)
      DOID:9206 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7158)
      DOID:9675 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
      DOID:14175 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7173)
      DOID:853 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7173)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155,HGNC:7158,HGNC:7173)
      DOID:9282 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7155)
  Molecular_info: Corresponding_CDS: C31B8.8
    Corresponding_transcript: C31B8.8.1
    Other_sequence (46)
    Associated_feature: WBsf652521
      WBsf233452
  Experimental_info: RNAi_result: WBRNAi00022666 Inferred_automatically: RNAi_primary
      WBRNAi00041600 Inferred_automatically: RNAi_primary
      WBRNAi00088998 Inferred_automatically: RNAi_primary
      WBRNAi00028230 Inferred_automatically: RNAi_primary
      WBRNAi00011430 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr14536
      Expr1016898
      Expr1145626
      Expr2018180
      Expr2036317
    Drives_construct: WBCnstr00021181
      WBCnstr00028192
      WBCnstr00040502
    Construct_product: WBCnstr00021181
      WBCnstr00028192
      WBCnstr00040502
    Antibody: WBAntibody00002300
    Microarray_results (17)
    Expression_cluster (183)
    Interaction (12)
  Map_info: Map: V Position: -12.8562
    Positive: Positive_clone: C31B8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00040289
    WBPaper00055090
    WBPaper00056095
    WBPaper00061665
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene