C05D2.3 generally resembles aromatic-L-amino-acid/L-histidine decarboxylases; however, its predicted protein sequence lacks six residues critical for AADC function.
Predicted to enable aromatic-L-amino-acid decarboxylase activity. Predicted to be involved in catecholamine metabolic process and serotonin biosynthetic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including aromatic L-amino acid decarboxylase deficiency; bipolar disorder; and hyperinsulinism. Is an ortholog of human DDC (dopa decarboxylase).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.