WormBase Tree Display for Gene: WBGene00014092

WBGene00014092 SMap: S_parent: Sequence: ZK822
  Identity: Version: 2
    Name: CGC_name: slc-5A12 Author_evidence: WBPerson555
      Sequence_name: ZK822.5
      Molecular_name: ZK822.5
        ZK822.5.1
        CE18466
      Other_name: CELE_ZK822.5 Accession_evidence: NDB BX284604
      Public_name: slc-5A12
    DB_info: Database: AceView gene 4M703
        WormQTL gene WBGene00014092
        WormFlux gene WBGene00014092
        NDB locus_tag CELE_ZK822.5
        Panther gene CAEEL|WormBase=WBGene00014092|UniProtKB=Q23616
          family PTHR42985
        NCBI gene 178127
        RefSeq protein NM_001047602.6
        TrEMBL UniProtAcc Q23616
        UniProt_GCRP UniProtAcc Q23616
        OMIM gene 601843
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:55 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 10 Jul 2023 23:47:10 WBPerson51134 Name_change: CGC_name: slc-5A12
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: slc
    Allele: WBVar00945870
      WBVar00945871
      WBVar00945872
      WBVar00945873
      WBVar00945874
      WBVar00945875
      WBVar00945876
      WBVar00945877
      WBVar00945878
      WBVar01500079
      WBVar00945879
      WBVar00945880
      WBVar00945881
      WBVar01482417
      WBVar00945882
      WBVar00945883
      WBVar00093441
      WBVar01702982
      WBVar01498811
      WBVar01498996
      WBVar01498261
      WBVar01499925
      WBVar01858842
      WBVar01858843
      WBVar01858844
      WBVar01858845
      WBVar00248615
      WBVar01494098
      WBVar02134762
      WBVar00436914
      WBVar00436915
      WBVar00436916
      WBVar00436917
      WBVar00436918
      WBVar00436919
      WBVar00436920
      WBVar00436921
      WBVar01454391
      WBVar01500245
      WBVar00192232
      WBVar01498775
    Strain: WBStrain00001221
      WBStrain00032464
    RNASeq_FPKM (74)
    GO_annotation: 00057527
      00057528
      00057529
      00057530
      00057531
      00057532
      00120820
      00120821
      00120822
    Ortholog (65)
    Paralog: WBGene00018716 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000501 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to enable symporter activity. Predicted to be involved in sodium ion transport. Predicted to be located in membrane. Expressed in several structures, including intestine; nervous system; non-striated muscle; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 1. Is an ortholog of human SLC5A12 (solute carrier family 5 member 12) and SLC5A8 (solute carrier family 5 member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0112185 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11040)
      DOID:0050328 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11040)
  Molecular_info: Corresponding_CDS: ZK822.5
    Corresponding_CDS_history: ZK822.5b:wp288
    Corresponding_transcript: ZK822.5.1
    Other_sequence (23)
    Associated_feature: WBsf646436
      WBsf660772
      WBsf997993
      WBsf229223
  Experimental_info: RNAi_result: WBRNAi00081182 Inferred_automatically: RNAi_primary
      WBRNAi00022181 Inferred_automatically: RNAi_primary
      WBRNAi00059746 Inferred_automatically: RNAi_primary
      WBRNAi00038452 Inferred_automatically: RNAi_primary
      WBRNAi00059745 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1396
      Expr7257
      Expr7258
      Expr1019115
      Expr1036312
      Expr1163169
      Expr2008982
      Expr2027218
    Drives_construct: WBCnstr00002114
      WBCnstr00004223
      WBCnstr00029316
    Construct_product: WBCnstr00029316
    Microarray_results (27)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00037950:bodywall-muscle_embryo_enriched
      WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Spermatogenic
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00046499:AMPK_regulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00048923:Aging_regulated
      WBPaper00048952:glucose_induced
      WBPaper00048971:daf-16(mgDf50)_upregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049905:Age_variant_expression
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:lin-15B(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Psora_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055364:uaf-1(n4588)_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055897:heat-shock_downregulated
      WBPaper00055941:atfs-1(et15)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00057158:mdt-15(tm2182)_dependent_15C_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059598:HeatShock_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00059895:wounding_downregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tdc-1(n3419)_downregulated
      WBPaper00061007:HB115_downregulated
      WBPaper00061007:M.braciatum_downregulated
      WBPaper00061040:eat-2(ad1116)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:nhr-107_19485-nhr-109_3743
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:hsf-1(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065749:Heat-Shock_downregulated_N2
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:4_0
      WBPaper00065841:4_1
      WBPaper00065841:4_2
      WBPaper00065841:38_2
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      cgc4489_group_17
      cgc4489_group_25
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_C
      WBPaper00040210:Chlorpyrifos_16C_regulated
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00049311:AgNO3_regulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc6390]:male_soma-enriched
    Interaction (15)
  Map_info: Map: IV Position: 5.43389
    Positive: Positive_clone: ZK822 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00034662
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene