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WormBase Tree Display for Gene: WBGene00013308

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Name Class

WBGene00013308SMapS_parentSequenceY57G11C
IdentityVersion4
NameCGC_namenuo-3Person_evidenceWBPerson1157
Sequence_nameY57G11C.12
Molecular_nameY57G11C.12
Y57G11C.12.1
CE14948
Y57G11C.12.2
Other_namendua-6Person_evidenceWBPerson555
CELE_Y57G11C.12Accession_evidenceNDBBX284604
Public_namenuo-3
DB_infoDatabaseWormQTLgeneWBGene00013308
WormFluxgeneWBGene00013308
NDBlocus_tagCELE_Y57G11C.12
PanthergeneCAEEL|WormBase=WBGene00013308|UniProtKB=O18236
familyPTHR12964
NCBIgene36805062
RefSeqproteinNM_001392444.1
TrEMBLUniProtAccO18236
UniProt_GCRPUniProtAccO18236
OMIMgene602138
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:54WBPerson1971EventImportedInitial conversion from CDS class of WS125
231 Aug 2005 14:07:05WBPerson2970Name_changeCGC_namenuo-3
306 Mar 2018 14:43:22WBPerson4025EventSplit_intoWBGene00303007
416 Jan 2023 18:37:21WBPerson51134Name_changeOther_namendua-6
Split_intoWBGene00303007
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnuo
Allele (27)
StrainWBStrain00003089
WBStrain00055406
RNASeq_FPKM (74)
GO_annotation00031815
00031816
00031817
00031818
00031819
00031820
00031821
00031822
00031823
Contained_in_operonCEOP5614
Ortholog (28)
Structured_descriptionConcise_descriptionThe nuo-3 locus encodes two distinct, non-overlapping proteins: Y57G11C.12a (homologous to human C3orf10/BRICK1, a component of the WAVE1 complex) and Y57G11C.12b (a putativeNADH-ubiquinone oxidoreductase alpha subunit, homologous to human NDUFA6 [OMIM:602138]).Person_evidenceWBPerson242
Curator_confirmedWBPerson567
Date_last_updated12 May 2008 00:00:00
Automated_descriptionPredicted to be involved in response to oxidative stress. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Alzheimer's disease and nuclear type mitochondrial complex I deficiency 33. Is an ortholog of human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0112097Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7690)
DOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7690)
Molecular_infoCorresponding_CDSY57G11C.12
Corresponding_CDS_historyY57G11C.12a:wp264
Y57G11C.12b:wp264
Corresponding_transcriptY57G11C.12.1
Y57G11C.12.2
Corresponding_transcript_historyY57G11C.12c:wp264
Associated_featureWBsf652383
WBsf981851
WBsf998642
WBsf231227
Experimental_infoRNAi_result (35)
Expr_patternChronogram977
Expr7077
Expr1012642
Expr1035936
Expr1161096
Expr2014529
Expr2032768
Drives_constructWBCnstr00003574
WBCnstr00029696
Construct_productWBCnstr00029696
Microarray_results (32)
Expression_cluster (107)
Interaction (87)
Map_infoMapIVPosition12.5086Error0.002306
PositivePositive_cloneY57G11CInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00005928
WBPaper00026715
WBPaper00031194
WBPaper00033840
WBPaper00037471
WBPaper00038491
WBPaper00041233
WBPaper00048636
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene