WormBase Tree Display for Gene: WBGene00013038

WBGene00013038 SMap: S_parent: Sequence: Y49E10
  Identity: Version: 2
    Name: CGC_name: ani-1 Person_evidence: WBPerson1816
            WBPerson1836
      Sequence_name: Y49E10.19
      Molecular_name: Y49E10.19
        Y49E10.19.1
        CE33878
        Y49E10.19.2
      Other_name: CELE_Y49E10.19 Accession_evidence: NDB BX284603
      Public_name: ani-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 15 Nov 2004 11:05:03 WBPerson2970 Name_change: CGC_name: ani-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ani
    Allele: WBVar02156924
      WBVar01449382
      WBVar01509320
      WBVar00869074
      WBVar00869075
      WBVar01509321
      WBVar00181596
      WBVar00869076
      WBVar00181597
      WBVar01509322
      WBVar01509323
      WBVar00181598
      WBVar00869077
      WBVar01509324
      WBVar00869078
      WBVar00181599
      WBVar00181600
      WBVar01509325
      WBVar00869079
      WBVar01509327
      WBVar00869080
      WBVar00181601
      WBVar00869081
      WBVar00181602
      WBVar02147628
      WBVar00869082
      WBVar00181603
      WBVar00181604
      WBVar00869083
      WBVar00869084
      WBVar00869085
      WBVar00869086
      WBVar00869087
      WBVar00869088
      WBVar00869089
      WBVar00869090
      WBVar00869091
      WBVar01920088
      WBVar01920089
      WBVar01920090
      WBVar01920091
      WBVar01920092
      WBVar01920093
      WBVar01920094
      WBVar01920095
      WBVar00219490
      WBVar00219491
      WBVar00219492
      WBVar00219494
      WBVar00262463
      WBVar00314856
      WBVar00102341
      WBVar01500138
      WBVar01500139
      WBVar01499774
      WBVar01398052
      WBVar01410180
      WBVar01410181
      WBVar01272883
      WBVar01272885
      WBVar01272887
      WBVar02053680
      WBVar01272890
      WBVar02053681
      WBVar02053682
      WBVar01953201
      WBVar00411653
      WBVar00411654
      WBVar00411655
      WBVar00317347
      WBVar01996044
      WBVar00411656
      WBVar00411657
      WBVar00411658
      WBVar00411659
      WBVar00411660
      WBVar01568205
      WBVar00411661
      WBVar01337708
      WBVar01568206
      WBVar01568207
      WBVar00411662
      WBVar01337712
      WBVar01568208
      WBVar01337716
      WBVar00411663
      WBVar00411664
      WBVar01337719
      WBVar00411665
      WBVar01337722
      WBVar00411666
      WBVar00411667
      WBVar00411668
      WBVar01838799
      WBVar00411669
      WBVar00601402
      WBVar01838800
      WBVar01838801
      WBVar00411670
      WBVar00411671
      WBVar01838802
      WBVar01702344
      WBVar00567201
      WBVar02132922
      WBVar02081913
      WBVar00234269
      WBVar00234270
      WBVar00869040
      WBVar01832627
      WBVar00869041
      WBVar00869042
      WBVar01832628
      WBVar00869043
      WBVar01832629
      WBVar01832630
      WBVar00869044
      WBVar02051295
      WBVar01832631
      WBVar02051296
      WBVar00869045
      WBVar00869046
      WBVar01832632
      WBVar02051297
      WBVar02051298
      WBVar00869047
      WBVar00869048
      WBVar00316565
      WBVar01771533
      WBVar00869049
      WBVar00869050
      WBVar00869051
      WBVar00869052
      WBVar00869053
      WBVar01990456
      WBVar00869054
      WBVar00869055
      WBVar01491585
      WBVar00869056
      WBVar00869057
      WBVar00869058
      WBVar00869059
      WBVar00869060
      WBVar00869061
      WBVar00869062
      WBVar00869063
      WBVar00869064
      WBVar00869065
      WBVar00869066
      WBVar00869067
      WBVar01509314
      WBVar00869068
      WBVar01509315
      WBVar00869069
      WBVar00869070
      WBVar01509316
      WBVar00869071
      WBVar01509317
      WBVar01449377
      WBVar00869072
      WBVar01509318
      WBVar00869073
      WBVar01449381
      WBVar01509319
    RNASeq_FPKM (74)
    GO_annotation (40)
    Contained_in_operon: CEOP3798
    Ortholog (34)
    Paralog: WBGene00007409 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012835 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019608 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: ani-1 encodes one of three C. elegans anillins; ANI-1 activity is required in the early embryo for cortical contractile events, including polar body extrusion, membrane ruffling, and pseudocleavage; at later stages of development, ANI-1 also plays a role in cuticle formation, coordinated locomotion, vulval development, and male tail formation; in regulating cortical events, ANI-1 appears to function by positively regulating septin (UNC-59 and UNC-61) localization to the contractile ring as well as formation of septin- and NMY-2-containing cortical patches; in telophase embryos, ANI-1 localizes to the cell cortex and cleavage furrow. Paper_evidence: WBPaper00025229
          Curator_confirmed: WBPerson1843
          Date_last_updated: 15 Nov 2007 00:00:00
      Automated_description: Enables actin filament binding activity; microtubule binding activity; and small GTPase binding activity. Involved in several processes, including first cell cycle pseudocleavage; nematode male tail tip morphogenesis; and organelle organization. Located in several cellular components, including cleavage furrow; growth cone; and midbody. Expressed in several structures, including QL.a; QL.pa; germ line; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Is an ortholog of human ANLN (anillin, actin binding protein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111133 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14082)
  Molecular_info: Corresponding_CDS: Y49E10.19
    Corresponding_CDS_history: Y49E10.19:wp99
    Corresponding_transcript: Y49E10.19.1
      Y49E10.19.2
    Other_sequence (21)
    Associated_feature: WBsf651542
      WBsf651543
      WBsf994647
      WBsf994648
      WBsf1016201
      WBsf1016202
      WBsf227667
      WBsf227668
  Experimental_info: RNAi_result (22)
    Expr_pattern: Expr3283
      Expr11252
      Expr12269
      Expr14312
      Expr1016866
      Expr1035795
      Expr1160457
      Expr2009335
      Expr2027571
    Drives_construct: WBCnstr00040016
    Construct_product: WBCnstr00005647
      WBCnstr00008813
      WBCnstr00008814
      WBCnstr00014920
      WBCnstr00020556
      WBCnstr00040016
    Antibody: WBAntibody00000927
    Microarray_results (19)
    Expression_cluster (181)
    Interaction (117)
  Map_info: Map: III Position: 17.8747 Error: 0.015814
    Positive: Positive_clone: Y49E10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (34)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene