| WBGene00012245 | SMap | S_parent | Sequence | CHROMOSOME_V |
|---|
| Identity | Version | 3 |
| | Name | CGC_name | rbm-25 | Person_evidence | WBPerson260 |
| | | Sequence_name | W04D2.6 |
| | | Molecular_name | W04D2.6a |
| | | | W04D2.6a.1 |
| | | | CE32000 |
| | | | W04D2.6b |
| | | | CE46600 |
| | | | W04D2.6c |
| | | | CE46822 |
| | | | W04D2.6b.1 |
| | | | W04D2.6c.1 |
| | | Other_name | CELE_W04D2.6 | Accession_evidence | NDB | BX284605 |
| | | Public_name | rbm-25 |
| | DB_info | Database | AceView | gene | 5M983 |
| | | | WormQTL | gene | WBGene00012245 |
| | | | WormFlux | gene | WBGene00012245 |
| | | | NDB | locus_tag | CELE_W04D2.6 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00012245|UniProtKB=H2L2D0 |
| | | | | family | PTHR18806 |
| | | | NCBI | gene | 259655 |
| | | | RefSeq | protein | NM_073733.6 |
| | | | | | NM_073732.8 |
| | | | | | NM_001269498.3 |
| | | | TREEFAM | TREEFAM_ID | TF320185 |
| | | | TrEMBL | UniProtAcc | H2L2D0 |
| | | | | | Q8I4F3 |
| | | | | | G5EE97 |
| | | | UniProt_GCRP | UniProtAcc | H2L2D0 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 |
| | | | 3 | 07 Dec 2017 13:24:47 | WBPerson1983 | Name_change | CGC_name | rbm-25 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | rbm |
| | Allele (78) |
| | Strain | WBStrain00051860 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00015678 |
| | | 00015679 |
| | | 00015680 |
| | | 00015681 |
| | | 00015682 |
| | | 00015683 |
| | | 00119399 |
| | | 00119400 |
| | Contained_in_operon | CEOP5352 |
| | Ortholog (38) |
| | Paralog | WBGene00012306 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019250 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | W04D2.6 encodes, by alternative splicing, two isoforms of an ortholog of human RBM25 (RED120); W04D2.6 is required (in conjunction with RSP-6) for normally rapid growth and (in conjunction with CPF-1 and F59A2.4) for oogenesis and embryonic viability; the long isoform of W04D2.6 has both an N-terminal RNA recognition domain (RRM) that is isoform-specific, and a C-terminal nucleic acid-binding domain (PWI) that is found in both isoforms; W04D2.6(RNAi) animals have a relatively subtle slow-growth phenotype, but display more severe synthetic phenotypes in double RNAi against both W04D2.6 and other putative splicing factors (CPF-1, RSP-6, or F59A2.4); W04D2.6 binds the N-terminal region of long UNC-13 isoforms in yeast two-hybrid assays; by orthology, W04D2.6 is expected to participate in splicing and 3'-end formation, and to bind RSR-1. | Paper_evidence | WBPaper00027120 |
| | | | | | WBPaper00030790 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 20 Oct 2007 00:00:00 |
| | | Automated_description | Predicted to enable mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in nucleus. Is an ortholog of human RBM25 (RNA binding motif protein 25). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | W04D2.6a |
| | | W04D2.6b |
| | | W04D2.6c |
| | Corresponding_CDS_history | W04D2.6a:wp87 |
| | | W04D2.6b:wp87 |
| | | W04D2.6b:wp229 |
| | Corresponding_transcript | W04D2.6a.1 |
| | | W04D2.6b.1 |
| | | W04D2.6c.1 |
| | Other_sequence (38) |
| | Associated_feature | WBsf647380 |
| | | WBsf655124 |
| | | WBsf661906 |
| | | WBsf661907 |
| | | WBsf1001599 |
| | | WBsf232661 |
| | | WBsf232662 |
| Experimental_info | RNAi_result (22) |
| | Expr_pattern | Expr1020547 |
| | | Expr1035424 |
| | | Expr1158307 |
| | | Expr2006771 |
| | | Expr2024994 |
| | Drives_construct | WBCnstr00030048 |
| | Construct_product | WBCnstr00030048 |
| | Microarray_results (26) |
| | Expression_cluster | WBPaper00028451:Low_abundance_spermatogenesis_enriched |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_downregulated_N2 |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00055013:HMG-3_interacting_protein |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059334:SACY-1_interacting |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:CAN |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DVA |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:R07E4.5-skp-1_1608 |
| | | WBPaper00061651:PDB_enriched |
| | | WBPaper00061651:RIB_enriched |
| | | WBPaper00062237:dnj-21(RNAi)_upregulated_protein |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065975:P-body_vs_oocyte_enriched |
| | | WBPaper00065975:P-body_vs_WholeAnimal_enriched |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | cgc4386_cluster_5_1 |
| | | cgc4489_group_12 |
| | | WBPaper00025032:cluster_87 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00026980:intestine_enriched |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00031060:2-deoxy-D-glucose_downregulated |
| | | WBPaper00032948:StarveUp4 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00037611:RNP-8-associated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040823:alg-1(gk214)_downregulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | [cgc5767]:cluster_21 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(53_min) |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | | [cgc6390]:Cluster_F |
| | | [cgc6390]:intrinsic |
| | Interaction (28) |
| Map_info | Map | V | Position | 4.41281 |
| | Positive | Positive_clone | W04D2 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference | WBPaper00027120 |
| | WBPaper00030790 |
| | WBPaper00031224 |
| | WBPaper00038491 |
| | WBPaper00046432 |
| | WBPaper00055090 |
| | WBPaper00062568 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
