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WormBase Tree Display for Gene: WBGene00012185

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Name Class

WBGene00012185SMapS_parentSequenceW01F3
IdentityVersion1
NameSequence_nameW01F3.2
Molecular_nameW01F3.2
W01F3.2.1
CE16530
Other_nameCELE_W01F3.2Accession_evidenceNDBBX284605
Public_nameW01F3.2
DB_infoDatabaseAceViewgene5V131
WormQTLgeneWBGene00012185
WormFluxgeneWBGene00012185
NDBlocus_tagCELE_W01F3.2
PanthergeneCAEEL|WormBase=WBGene00012185|UniProtKB=O62390
familyPTHR10201
NCBIgene180351
RefSeqproteinNM_075591.6
TREEFAMTREEFAM_IDTF344186
TrEMBLUniProtAccO62390
UniProt_GCRPUniProtAccO62390
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
StatusLive
Gene_infoBiotypeSO:0001217
Allele (53)
RNASeq_FPKM (74)
Ortholog (40)
ParalogWBGene00006987Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00010423Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00010524Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00016283Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00020646Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00019212Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00012364Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00194737Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionAutomated_descriptionEnriched in AIB; SIB; germline precursor cell; and hypodermis based on tiling array and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and skn-1 based on microarray; tiling array; RNA-seq; and proteomic studies. Is affected by nineteen chemicals including 1-methylnicotinamide; manganese chloride; and sodium arsenite based on RNA-seq; microarray; and proteomic studies. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and carcinoma (multiple). Human MMP9 enables identical protein binding activity; metalloendopeptidase activity; and serine-type endopeptidase activity. Is predicted to encode a protein with the following domain: Hemopexin-like domain superfamily. Is an ortholog of human MMP2 (matrix metallopeptidase 2); MMP23B (matrix metallopeptidase 23B); and MMP9 (matrix metallopeptidase 9).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (122)
Molecular_infoCorresponding_CDSW01F3.2
Corresponding_transcriptW01F3.2.1
Other_sequenceDviv_isotig31079
CBC02137_1
Acan_isotig12815
Tcir_isotig04024
Hbac_isotig02725
CR07048
CRC02265_1
Tcol_isotig02099
CR00258
Tcol_isotig02100
Associated_featureWBsf647751
WBsf1003606
WBsf1003607
WBsf1021987
WBsf233211
WBsf233212
Experimental_infoRNAi_resultWBRNAi00054529Inferred_automaticallyRNAi_primary
WBRNAi00036151Inferred_automaticallyRNAi_primary
Expr_patternExpr1012510
Expr1035387
Expr1158075
Expr2006671
Expr2024888
Drives_constructWBCnstr00030077
Construct_productWBCnstr00030077
Microarray_results (20)
Expression_clusterWBPaper00005700:secreted_protein
WBPaper00025192:hda-1(RNAi)_upregulated
WBPaper00030922:glycosylated_protein
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00032031:DConiospora_upregulated_cDNA_12h
WBPaper00032031:DConiospora_upregulated_cDNA_24h
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00035073:mitochondria_protein
WBPaper00037047:aging_accelerated_insoluble_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:germline-precursors_embryo_enriched
WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:hypodermis_larva_enriched
WBPaper00037950:hypodermis_larva_SelectivelyEnriched
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00038168:lin-15B(n744)_upregulated
WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
WBPaper00040560:hpl-2_L3_upregulated
WBPaper00040990:PA14_downregulated
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00044037:eat-2_upregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044736:oscillating_dev_expression
WBPaper00044746:aging_upregulated_HeatShock
WBPaper00044857:BAR-1_downregulated
WBPaper00045017:blmp-1(tm548)_upregulated
WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
WBPaper00045314:S.aureus-induced_N2
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045774:clk-1_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048611:MnCl2_downregulated
WBPaper00048988:neuron_expressed
WBPaper00049098:heat-induced_hrde-1(tm1200)
WBPaper00049134:hpk-1(pk1393)_upregulated
WBPaper00049177:rpn-10(ok1865)_downregulated
WBPaper00049217:TCER-1_downregulated
WBPaper00049266:NaAsO2-Stress_regulated_N2
WBPaper00049266:NaAsO2-Stress_regulated_trx-1(ok1449)
WBPaper00049498:npr-1(ur89)_regulated_8
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049905:Age_variant_expression
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049920:hyl-2(tm2031)_upregulated
WBPaper00050080:rbr-2(tm3141)_downregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050448:KGB-1-induced
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
WBPaper00050488:20C_vs_25C_regulated_N2_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050636:aging_regulated_insoluble_protein
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050903:mir-35-41(nDf50)_20C_upregulated
WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
WBPaper00050990:body-muscle_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051265:F4_morc-1(tm6048)_downregulated
WBPaper00051388:Glucose-diet_upregulated
WBPaper00051404:alg-5(ram2)_downregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(ot267)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053318:mir-71(n4115)_upregulated_mRNA
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00053615:SMO-1_target
WBPaper00053657:JU2519_M.humicola-infection_12hr
WBPaper00053657:JU2519_M.humicola-infection_24hr
WBPaper00053657:N2_M.humicola-infection_12hr
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:15C_downregulated_OP50
WBPaper00053814:15C_downregulated_PY79
WBPaper00054191:H3.3(null)_embryo_upregulated
WBPaper00054493:hpl-2(tm1489)_downregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055013:hmg-4(RNAi)_upregulated
WBPaper00055013:spt-16(RNAi)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Psora_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055827:daf-2(e1370)_upregulated
WBPaper00055827:pfd-6(gk493446)_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00056039:efa-6(tm3124)_downregulated
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056167:Cry5B_downregulated
WBPaper00056167:ifo-1(kc2)_downregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_L1
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056169:rrf-3(pk1426)_upregulated_L3
WBPaper00056169:rrf-3(pk1426)_upregulated_L4
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_upregulated
WBPaper00056446:hsb-1(cg116)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057006:DietaryRestriction_downregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00057158:mdt-15(tm2182)_dependent_15C_downregulated
WBPaper00057288:Cold_downregulated_protein
WBPaper00058711:wdr-5(ok1417)_upregulated
WBPaper00058725:sftb-1(cer39)_upregulated
WBPaper00058927:high-redox-state_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059191:hsp-16.2p-LIN-29_upregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059537:ngn-1(ok2200)_upregulated
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059735:glucose_downregulated_lpin-1(RNAi)
WBPaper00059739:hira-1(gk835598)_upregulated_L4
WBPaper00059816:crh-1(n3315)_downrgulated
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
WBPaper00060445:ikb-1(nr2027)_upregulated_L1
WBPaper00060445:nfki-1(cer1)_downregulated_L1
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060703:nas-38(ok3407)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060871:M.humicola-infection_12h_regulated
WBPaper00060871:M.humicola-infection_24h_regulated
WBPaper00060909:atfs-1(et18)_upregulated
WBPaper00060921:cat-2(e1112)_downregulated
WBPaper00060921:tdc-1(n3419)_downregulated
WBPaper00060921:tph-1(mg280)_downregulated
WBPaper00061045:Y56A3A.22(cck200)_upregulated
WBPaper00061340:AIB
WBPaper00061340:SIB
WBPaper00061341:28C_24h_upregulated
WBPaper00061527:W01F3.2_1554-Y106G6D.8
WBPaper00061699:daf-18(ok480)_downregulated
WBPaper00061823:mex-3(spr9)_downregulated
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062078:NMR-HspB1_regulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062335:sir-2.1(ok434)_upregulated_L3
WBPaper00062347:blmp-1(tm548)_upregulated
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062354:H.zoospora_12h_regulated
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062587:lsl-1(ljm1)_upregulated
WBPaper00062587:lsl-1(tm4769)_upregulated
WBPaper00062590:Aging_upregulated_neuron
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064158:xpo-1(RNAi)_upregulated
WBPaper00064494:postdauer_upregulated_AWA
WBPaper00064532:pals-22(jy3)_downregulated
WBPaper00064539:nhr-114(gk849)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064952:Day5_vs_L4_upregulated_20C
WBPaper00064952:Day5_vs_L4_upregulated_25C
WBPaper00064952:Day10_vs_Day1_upregulated_20C
WBPaper00064952:Day10_vs_Day1_upregulated_25C
WBPaper00064952:Day10_vs_L4_upregulated_20C
WBPaper00064952:Day10_vs_L4_upregulated_25C
WBPaper00064992:Capsaicin_downregulated
WBPaper00065074:glna(-)_upregulated
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C
WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C
WBPaper00065158:25C_vs_15C_upregulated_AFD
WBPaper00065158:AFD_depleted
WBPaper00065199:Transgeneration-starvation_regulated_fed
WBPaper00065288:mdt-15(tm2182)_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065746:eat-2(ad1113)_upregulated
WBPaper00065759:dot-1.1(knu339)_upregulated
WBPaper00065841:2_0
WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065984:pals-17(syb3980)_upregulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:Doxorubicin_upregulated_diploid
cgc4489_group_9
WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
WBPaper00025099:MA_specific
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00029437:dcr-1_upregulated
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032062:age_regulated_genes
WBPaper00034739:RIL17moreRIL14
WBPaper00034757:up_by_oxidative_stress
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00036286:Pattern_D
WBPaper00037695:LD_DD_6-day
WBPaper00037695:WC_5-day
WBPaper00038172:crh-1null_up_regulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00038231:Cry5B_2-fold_upregulated
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.5
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00041002:HF_3d_0.2mM_Up
WBPaper00041002:HQ_3d_0.2mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041207:CE_dauer_up
WBPaper00041211:RPW-24_Up
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_B.thuringiensis-DB27_regulated
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
WBPaper00042128:gei-8(ok1671)_upregulated
WBPaper00042258:DA1877_upregulated_YoungAdult
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00046083:oga-1(ok1207)_OP50_upregulated
WBPaper00046548:dafachronic-acid_downregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_rapamycin_upregulated
WBPaper00050515:nipi-3(fr4)_upregulated
WBPaper00050520:lagr-1(gk327);hyl-1(ok976)_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
Interaction (201)
Map_infoPositivePositive_cloneW01F3Inferred_automaticallyFrom sequence, transcript, pseudogene data
Interpolated_map_positionV25.0306
MethodGene