WormBase Tree Display for Gene: WBGene00012005

WBGene00012005 SMap: S_parent: Sequence: CHROMOSOME_II
  Identity: Version: 4
    Name: CGC_name: jun-1 Person_evidence: WBPerson2962
            WBPerson443
      Sequence_name: T24H10.7
      Molecular_name (27)
      Other_name: CELE_T24H10.7 Accession_evidence: NDB BX284602
      Public_name: jun-1
    DB_info: Database: AceView gene 2J421
        WormQTL gene WBGene00012005
        WormFlux gene WBGene00012005
        NDB locus_tag CELE_T24H10.7
        Panther gene CAEEL|WormBase=WBGene00012005|UniProtKB=G5ECU7
          family PTHR11462
        NCBI gene 174452
        RefSeq protein NM_001356878.3
            NM_001356880.3
            NM_001136355.4
            NM_001356881.3
            NM_001383910.2
            NM_001356879.3
            NM_001027195.4
            NM_001027197.5
            NM_001027196.5
        SwissProt UniProtAcc G5ECU7
        TrEMBL UniProtAcc A0A2C9C3K0
            A0A2C9C3E7
            A0A2C9C2T0
            A0A2C9C2Y8
        UniProt_GCRP UniProtAcc G5ECU7
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 29 Nov 2004 12:57:28 WBPerson1983 Event: Acquires_merge: WBGene00012001
        3 27 Apr 2007 10:10:56 WBPerson1983 Event: Acquires_merge: WBGene00012006
        4 07 Nov 2007 09:36:21 WBPerson2970 Name_change: CGC_name: jun-1
      Acquires_merge: WBGene00012001
        WBGene00012006
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: jun
    Allele (304)
    Strain: WBStrain00036395
      WBStrain00036410
    RNASeq_FPKM (74)
    GO_annotation (28)
    Contained_in_operon: CEOP2709
    Ortholog (31)
    Structured_description: Concise_description: jun-1 encodes a basic-leucine zipper (bZIP) transcription factor that is the C. elegans JUN homolog; jun-1 activity is essential for regulation of ovulation, and thus normal levels of fertility; in regulating ovulation, JUN-1 functions with FOS-1 to regulate expression of plc-1 which encodes a phospholipase C essential for IP3 production and ovulation; in addition, JUN-1 interacts with FOS-1 in vitro to form heterodimers capable of binding upstream regulatory sequences of egl-13, which encodes a transcription factor required for uterine cell fate specification; jun-1 is expressed in the uterus and the spermatheca. Paper_evidence: WBPaper00031111
            WBPaper00034689
          Curator_confirmed: WBPerson1843
          Date_last_updated: 19 Jan 2010 00:00:00
      Automated_description: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Expressed in several structures, including excretory cell; hermaphrodite gonad; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and lymphoma (multiple). Is an ortholog of human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (22)
  Molecular_info: Corresponding_CDS: T24H10.7a
      T24H10.7b
      T24H10.7c
      T24H10.7d
      T24H10.7e
      T24H10.7f
      T24H10.7g
      T24H10.7h
      T24H10.7i
    Corresponding_CDS_history: T24H10.7:wp136
    Corresponding_transcript: T24H10.7a.1
      T24H10.7b.1
      T24H10.7c.1
      T24H10.7d.1
      T24H10.7e.1
      T24H10.7f.1
      T24H10.7g.1
      T24H10.7h.1
      T24H10.7i.1
    Other_sequence (42)
    Associated_feature (34)
    Gene_product_binds: WBsf028064
      WBsf977574
      WBsf977575
      WBsf977576
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      WBsf977948
    Transcription_factor: WBTranscriptionFactor000109
      WBTranscriptionFactor000501
  Experimental_info: RNAi_result (33)
    Expr_pattern (14)
    Drives_construct: WBCnstr00012826
      WBCnstr00014260
      WBCnstr00014283
      WBCnstr00014284
      WBCnstr00014288
      WBCnstr00014300
      WBCnstr00014302
      WBCnstr00030207
    Construct_product: WBCnstr00030207
    Microarray_results (48)
    Expression_cluster (184)
    Interaction (46)
  Map_info: Map: II Position: 1.04759 Error: 0.001496
    Positive: Positive_clone: T24H10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (24)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene