WormBase Tree Display for Gene: WBGene00011904

WBGene00011904 SMap: S_parent: Sequence: T21H8
  Identity: Version: 3
    Name: CGC_name: hlb-1 Paper_evidence: WBPaper00033002
      Sequence_name: T21H8.1
      Molecular_name (58)
      Other_name: CELE_T21H8.1 Accession_evidence: NDB BX284606
      Public_name: hlb-1
    DB_info: Database: AceView gene XO484
        WormQTL gene WBGene00011904
        WormFlux gene WBGene00011904
        NDB locus_tag CELE_T21H8.1
        Panther gene CAEEL|WormBase=WBGene00011904|UniProtKB=Q94071
          family PTHR12587
        NCBI gene 181499
        RefSeq protein (19)
        SwissProt UniProtAcc Q94071
        UniProt_GCRP UniProtAcc Q94071
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:53 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 23 Apr 2010 11:09:26 WBPerson2970 Name_change: CGC_name: hlb-1
        3 18 Feb 2016 15:51:46 WBPerson1983 Event: Acquires_merge: WBGene00011905
      Acquires_merge: WBGene00011905
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: hlb
    Allele (327)
    Strain: WBStrain00031591
    RNASeq_FPKM (74)
    GO_annotation: 00086974
      00086975
      00086976
      00086977
      00086978
      00086979
    Ortholog (43)
    Paralog: WBGene00006364 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: hlb-1 encodes the C. elegans ortholog of human beta-liprin, a coiled-coil domain-containing protein that interacts with alpha-liprin, a transmembrane protein-tyrosine phosphatase-interacting protein; hlb-1 functions cell non-autonomously in the organization and proper function of neuromuscular junctions and hence, is also required for wild type locomotory behavior; an hlb-1 reporter fusion construct directs expression in pharyngeal and body wall muscles, and in regions adjacent to the dorsal and ventral nerve cords; expression in the pharynx is particularly strong in the posterior bulb. Paper_evidence: WBPaper00003493
            WBPaper00004651
            WBPaper00005654
            WBPaper00025054
            WBPaper00030810
            WBPaper00033002
          Curator_confirmed: WBPerson1843
          Date_last_updated: 23 Apr 2010 00:00:00
      Automated_description: Involved in several processes, including neuromuscular junction development; positive regulation of locomotion; and regulation of pharyngeal pumping. Predicted to be located in presynaptic active zone. Is an ortholog of human PPFIBP1 (PPFIA binding protein 1) and PPFIBP2 (PPFIA binding protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS (19)
    Corresponding_CDS_history: T21H8.1:wp131
      T21H8.1:wp178
    Corresponding_transcript (20)
    Other_sequence (35)
    Associated_feature (21)
  Experimental_info: RNAi_result: WBRNAi00035776 Inferred_automatically: RNAi_primary
      WBRNAi00053770 Inferred_automatically: RNAi_primary
      WBRNAi00018991 Inferred_automatically: RNAi_primary
      WBRNAi00001136 Inferred_automatically: RNAi_primary
      WBRNAi00053766 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2088
      Expr1011344
      Expr1025976
      Expr1035250
      Expr1035251
      Expr1157316
      Expr1157320
      Expr2012489
      Expr2030728
    Drives_construct: WBCnstr00030295
      WBCnstr00030296
    Construct_product: WBCnstr00030295
      WBCnstr00030296
    Microarray_results (42)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032976:dosage_compensated_genes
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045316:prg-1_upregulated_L2
      WBPaper00045316:prg-1_upregulated_L3
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055226:ADR-2_target_N2
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AVG
      WBPaper00061340:mc3
      WBPaper00061340:OLL_parent
      WBPaper00061340:pm8
      WBPaper00061466:nath-10(icb102)_downregulated
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:176662_at-Y53F4B.16
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:saeg-1_18803-mpz-2_15880
      WBPaper00061651:AVG_enriched
      WBPaper00061651:I1_enriched
      WBPaper00061651:PVM_enriched
      WBPaper00061651:VC_4_5_enriched
      WBPaper00061818:ELKS-1_interacting
      WBPaper00061902:camt-1(ok515)_regulated_AFD
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065841:49_0
      WBPaper00065841:54_0
      WBPaper00065841:68_0
      WBPaper00065841:68_1
      WBPaper00065841:96_0
      WBPaper00065841:124_0
      WBPaper00065841:131_0
      WBPaper00065841:145_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_4
      cgc4489_group_5
      WBPaper00025032:cluster_12
      WBPaper00025032:cluster_104
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00027111:rrf-3(pk1426)_downregulated
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:hlh_1_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_C
      WBPaper00037695:WC_5-day
      WBPaper00038304:octr-1_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00042574:JU1580_OrsayVirus_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(143_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(143_min)
      [cgc6390]:Cluster_B
    Interaction (44)
  Map_info: Map: X Position: 15.0875
    Positive: Positive_clone: T21H8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00003493
    WBPaper00030810
    WBPaper00031717
    WBPaper00033002
    WBPaper00035492
    WBPaper00038491
    WBPaper00055090
    WBPaper00064473
    WBPaper00064480
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods.
  Method: Gene