WormBase Tree Display for Gene: WBGene00006364
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| WBGene00006364 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | F59F5 | ||||||
| Identity | Version | 2 | |||||||
| Name | CGC_name | syd-2 | Person_evidence | WBPerson105 | |||||
| WBPerson293 | |||||||||
| Sequence_name | F59F5.6 | ||||||||
| Molecular_name | F59F5.6 | ||||||||
| F59F5.6.1 | |||||||||
| CE03447 | |||||||||
| F59F5.6.2 | |||||||||
| Other_name | sad-2 | Person_evidence | WBPerson42 | ||||||
| CELE_F59F5.6 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | syd-2 | ||||||||
| DB_info | Database | AceView | gene | XL168 | |||||
| WormQTL | gene | WBGene00006364 | |||||||
| WormFlux | gene | WBGene00006364 | |||||||
| NDB | locus_tag | CELE_F59F5.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006364|UniProtKB=Q21049 | |||||||
| family | PTHR12587 | ||||||||
| NCBI | gene | 181255 | |||||||
| RefSeq | protein | NM_077367.10 | |||||||
| SwissProt | UniProtAcc | Q21049 | |||||||
| UniProt_GCRP | UniProtAcc | Q21049 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 14 Jan 2008 11:42:52 | WBPerson2970 | Event | Acquires_merge | WBGene00004720 | ||||
| Name_change | Other_name | sad-2 | |||||||
| Acquires_merge | WBGene00004720 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | syd | ||||||||
| Allele (95) | |||||||||
| Legacy_information | [Zhen M, Jin Y ] ju37 homozygotes exhibit diffuse localization of several presynaptic proteins and SNB-1::GFP. Also mild behavioral defects: sluggish locomotion, defective egg-laying. syd-2 cloned: F59F5.6, encoding a liprin family member. | ||||||||
| Strain | WBStrain00040850 | ||||||||
| WBStrain00005356 | |||||||||
| WBStrain00054705 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00011904 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | syd-2 encodes alpha-liprin, a member of the liprin family of proteins that interact with LAR (leukocyte common antigen related)-type receptor tyrosine phosphatases (RPTPs) to facilitate clustering of RPTPs to focal adhesions; SYD-2 is required for establishing normal presynaptic density, and is expressed in all neurons and muscles; SYD-2 is required cell autonomously in neurons for differentiation of presynaptic active zones, where SYD-2 is localized; the SYD-2 liprin homology domain 1 (LH1) self-associates in vitro, suggesting that SYD-2 self-assembly contributes to its role in presynaptic assembly in vivo. | Paper_evidence | WBPaper00003493 | |||||
| WBPaper00003678 | |||||||||
| WBPaper00005118 | |||||||||
| WBPaper00040398 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Feb 2012 00:00:00 | ||||||||
| Automated_description | Enables several functions, including cytoskeletal motor activator activity; kinesin binding activity; and protein homodimerization activity. Involved in several processes, including anterograde synaptic vesicle transport; egg-laying behavior; and positive regulation of anterograde synaptic vesicle transport. Located in axon; cytoplasm; and presynaptic active zone dense projection. Expressed in several structures, including excretory gland cell; nervous system; pharyngeal gland cell; rectal gland cell; and uv1. Is an ortholog of human PPFIA3 (PTPRF interacting protein alpha 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F59F5.6 | |||||||
| Corresponding_transcript | F59F5.6.1 | ||||||||
| F59F5.6.2 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00034390 | ||||||||
| Construct_product (28) | |||||||||
| Antibody | WBAntibody00000239 | ||||||||
| WBAntibody00000842 | |||||||||
| WBAntibody00000843 | |||||||||
| WBAntibody00001726 | |||||||||
| WBAntibody00001908 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (100) | |||||||||
| Map_info | Map | X | Position | 2.2383 | Error | 0.005546 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F39F5 | |||||||
| F59F5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4022 | |||||||
| 4023 | |||||||||
| 4532 | |||||||||
| Reference (100) | |||||||||
| Remark | Sequence connection from [Zhen M, Jin Y] | ||||||||
| Data extracted from Zhen and Jin (1999) | |||||||||
| F39F5.6 appears to be a misprint and has been removed. [sdm 0107] | |||||||||
| Method | Gene |
