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WormBase Tree Display for Gene: WBGene00011095

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Name Class

WBGene00011095SMapS_parentSequenceR07B7
IdentityVersion2
NameCGC_namegana-1Paper_evidenceWBPaper00024919
Sequence_nameR07B7.11
Molecular_nameR07B7.11
R07B7.11.1
CE06273
Other_nameCELE_R07B7.11Accession_evidenceNDBBX284605
Public_namegana-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:52WBPerson1971EventImportedInitial conversion from CDS class of WS125
211 Feb 2005 11:14:24WBPerson2970Name_changeCGC_namegana-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgana
Allele (28)
StrainWBStrain00002061
WBStrain00033052
WBStrain00052080
RNASeq_FPKM (74)
GO_annotation (13)
Ortholog (44)
Structured_descriptionConcise_descriptiongana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes. the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency.Paper_evidenceWBPaper00004637
WBPaper00024995
Curator_confirmedWBPerson324
WBPerson1823
WBPerson567
Date_last_updated13 Jul 2007 00:00:00
Automated_descriptionPredicted to enable alpha-galactosidase activity. Involved in glycoside catabolic process. Located in cytoplasm. Expressed in coelomocyte. Used to study Fabry disease. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; Schindler disease (multiple); and angiokeratoma. Is an ortholog of human GLA (galactosidase alpha) and NAGA (alpha-N-acetylgalactosaminidase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:14499Homo sapiensPaper_evidenceWBPaper00024995
Accession_evidenceOMIM301500
Curator_confirmedWBPerson324
Date_last_updated26 Mar 2013 00:00:00
Potential_modelDOID:14499Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4296)
DOID:0112318Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7631)
DOID:479Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7631)
DOID:0112319Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7631)
DOID:2367Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:7631)
Disease_relevanceElegans gana-1 is orthologous to the human NAGA and GALA genes; the human gene Alpha-N-acetylgalactosaminidase (NAGA, also known as GALB) is a lysosomal glycohydrolase, that cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates; mutations in GALB have been associated with Schindler disease type I and III and Kanzaki disease; mutations in human alpha-galactosidase (GLA), a lysosomal hydrolase are associated with Fabry disease.Homo sapiensPaper_evidenceWBPaper00031904
WBPaper00024995
Accession_evidenceOMIM609242
609241
301500
300644
Curator_confirmedWBPerson324
Date_last_updated08 May 2013 00:00:00
Models_disease_in_annotationWBDOannot00000117
Molecular_infoCorresponding_CDSR07B7.11
Corresponding_transcriptR07B7.11.1
Other_sequence (42)
Associated_featureWBsf661853
WBsf232594
WBsf232595
Experimental_infoRNAi_resultWBRNAi00034684Inferred_automaticallyRNAi_primary
WBRNAi00017514Inferred_automaticallyRNAi_primary
WBRNAi00051428Inferred_automaticallyRNAi_primary
WBRNAi00061279Inferred_automaticallyRNAi_primary
Expr_patternChronogram1180
Expr3168
Expr6474
Expr6475
Expr1010714
Expr1034872
Expr1155117
Expr2011940
Expr2030177
Drives_constructWBCnstr00002845
WBCnstr00004440
WBCnstr00011188
WBCnstr00030937
Construct_productWBCnstr00011188
WBCnstr00016579
WBCnstr00016580
WBCnstr00030937
Microarray_results (19)
Expression_clusterWBPaper00029359_1197
WBPaper00029359_1225
WBPaper00029359_1291
WBPaper00029359_1494
WBPaper00029359_1546
WBPaper00030922:glycosylated_protein
WBPaper00031040:Cluster_5
WBPaper00032425:down_in_lin-35
WBPaper00032425:down_in_zfp-1
WBPaper00032528:L3_enriched
WBPaper00033070:Elbe_upregulated
WBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037950:bodywall-muscle_L1-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_embryo_enriched
WBPaper00037950:intestine_embryo_SelectivelyEnriched
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_embryo_enriched
WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:oscillating_dev_expression
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045774:clk-1_upregulated
WBPaper00046012:tdp-1(ok803)_upregulated
WBPaper00046024:sleep_downregulated_oscillating
WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046497:B.thuringiensis_upregulated_protein
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050053:muscle_enriched_Day4
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050801:DPY-21_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051352:Long-Term-Association-Memory_upregulated
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster3
WBPaper00053402:cco-1(RNAi)_upregulated
WBPaper00053615:SMO-1_target
WBPaper00053810:clk-1(qm30)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053810:sod-2(ok1030)_upregulated
WBPaper00054410:set-9(rw5)_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055626:pry-1(mu38)_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057006:DietaryRestriction_downregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060100:SiNP_downregulated_mRNA
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060703:nas-38(ok3407)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:BWM_anterior
WBPaper00061340:BWM_far_posterior
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061405:S.aureus_downregulated_starvation
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061527:mlt-9_22518-F33D4.6_14044
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062293:isp-1(qm150)_upregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064871:hypoxia_downregulated_F1
WBPaper00064952:Day10_vs_L4_downregulated_20C
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:4_0
WBPaper00065841:4_1
WBPaper00065841:4_2
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4386_cluster_6_6
cgc4489_group_8
WBPaper00005124:cholesterol_10-9M_regulated
WBPaper00025032:cluster_5
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00031003:24hr_muscle_enriched
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_enriched
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00034739:N2lessDR1350
WBPaper00035227:heat_shock_regulated
WBPaper00036286:Pattern_C
WBPaper00037113:Diazinon_16C_regulated
WBPaper00038172:aak-2overexpression_down_regulated
WBPaper00038172:crh-1null_up_regulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038304:octr-1_regulated
WBPaper00040963:Q100_down
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00044091:Bpseudomallei_repressed_12h
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00053236:Starvation_regulated_N2
WBPaper00055899:nitroguanidine_regulated
WBPaper00056330:mrps-5(RNAi)_upregulated
[cgc5376]:let-60(G12V)-regulated_genes
[cgc5767]:cluster_2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:Cluster_B
InteractionWBInteraction000123322
WBInteraction000396593
WBInteraction000416572
WBInteraction000504156
WBInteraction000551639
Map_info (3)
ReferenceWBPaper00024995
WBPaper00038491
WBPaper00042257
WBPaper00055090
WBPaper00064161
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene