WormBase Tree Display for Gene: WBGene00011045

WBGene00011045 SMap: S_parent: Sequence: R05H10
  Identity: Version: 2
    Name: CGC_name: gpx-2 Person_evidence: WBPerson261
      Sequence_name: R05H10.5
      Molecular_name: R05H10.5a
        R05H10.5a.1
        CE18107
        R05H10.5b
        CE48951
        R05H10.5b.1
      Other_name: CELE_R05H10.5 Accession_evidence: NDB BX284602
      Public_name: gpx-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:52 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Jul 2012 14:20:02 WBPerson2970 Name_change: CGC_name: gpx-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gpx
    Allele (74)
    RNASeq_FPKM (74)
    GO_annotation (12)
    Contained_in_operon: CEOP2652
    Ortholog (40)
    Paralog: WBGene00007516 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00007517 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00009165 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00020373 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00022377 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018850 Caenorhabditis elegans From_analysis: Panther
      WBGene00019846 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Automated_description: Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and spondylometaphyseal dysplasia Sedaghatian type. Is an ortholog of human GPX4 (glutathione peroxidase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:3717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:1184 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:0112298 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
  Molecular_info: Corresponding_CDS: R05H10.5a
      R05H10.5b
    Corresponding_transcript: R05H10.5a.1
      R05H10.5b.1
    Other_sequence (130)
    Associated_feature: WBsf658446
      WBsf658447
      WBsf222518
  Experimental_info: RNAi_result: WBRNAi00051338 Inferred_automatically: RNAi_primary
      WBRNAi00034637 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1010923
      Expr1034846
      Expr1155031
      Expr2012216
      Expr2030452
    Microarray_results (23)
    Expression_cluster: WBPaper00035073:mitochondria_protein
      WBPaper00035269:cde-1_regulated
      WBPaper00036144:dauer_upregulated_protein
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:excretory-cell_larva_enriched
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00038118:stress_downregulated_N2
      WBPaper00038289:oocyte_protein
      WBPaper00040529:TWE_regulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044128:daf-2(e1370)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045390:tunicamycin_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050332:juglone_upregulated
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053792:Ochrobactrum_downregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061527:hlh-30_18579-unc-43_21739
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00062123:DEPS-1_interacting
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062590:Aging_downregulated_neuron
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064494:postdauer_downregulated_AWA
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031832:slr-2_regulated
      WBPaper00035560:ahr-1_upregulated
      WBPaper00041002:HF_11d_0.2mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00048624:hlh-25(ok1710)_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
    SAGE_tag: SAGE:cgagatcgatatcgccg Strand: Sense
        Unambiguously_mapped
      SAGE:atggttcctgaccaccg Strand: Antisense
      SAGE:cgagatcgat Strand: Sense
        Unambiguously_mapped
    Interaction (114)
  Map_info: Map: II Position: 23.663
    Positive: Positive_clone: R05H10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042257
    WBPaper00044578
    WBPaper00045706
    WBPaper00055090
    WBPaper00060484
    WBPaper00061220
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene