WormBase Tree Display for Gene: WBGene00008439

WBGene00008439 SMap: S_parent: Sequence: DY3
  Identity: Version: 2
    Name: CGC_name: mfb-1 Paper_evidence: WBPaper00024548
      Sequence_name: DY3.6
      Molecular_name: DY3.6
        DY3.6.1
        CE15750
      Other_name: tag-220 Curator_confirmed: WBPerson2970
        CELE_DY3.6 Accession_evidence: NDB BX284601
      Public_name: mfb-1
    DB_info: Database: AceView gene 1J356
        WormQTL gene WBGene00008439
        WormFlux gene WBGene00008439
        NDB locus_tag CELE_DY3.6
        Panther gene CAEEL|WormBase=WBGene00008439|UniProtKB=O45323
          family PTHR13123
        NCBI gene 183975
        RefSeq protein NM_059975.5
        TREEFAM TREEFAM_ID TF313070
        TrEMBL UniProtAcc O45323
        UniProt_GCRP UniProtAcc O45323
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 22 Dec 2004 08:53:54 WBPerson2970 Name_change: CGC_name: mfb-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mfb
    Allele (70)
    Strain: WBStrain00002459
      WBStrain00002900
      WBStrain00035998
    RNASeq_FPKM (74)
    GO_annotation: 00034241
      00034242
      00034243
      00034244
      00034245
      00034246
    Ortholog (40)
    Structured_description: Automated_description: Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SCF ubiquitin ligase complex. Expressed in several structures, including head; hypodermal cell; tail; touch receptor neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Is an ortholog of human FBXO25 (F-box protein 25) and FBXO32 (F-box protein 32). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:14557 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:16731)
  Molecular_info (4)
  Experimental_info: RNAi_result: WBRNAi00060999 Inferred_automatically: RNAi_primary
      WBRNAi00116913 Inferred_automatically: RNAi_primary
      WBRNAi00030444 Inferred_automatically: RNAi_primary
      WBRNAi00060998 Inferred_automatically: RNAi_primary
      WBRNAi00113747 Inferred_automatically: RNAi_primary
      WBRNAi00060997 Inferred_automatically: RNAi_primary
      WBRNAi00043553 Inferred_automatically: RNAi_primary
      WBRNAi00061000 Inferred_automatically: RNAi_primary
      WBRNAi00113743 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00003056
      WBCnstr00004524
      WBCnstr00011153
      WBCnstr00020326
    Construct_product: WBCnstr00011153
    Microarray_results (18)
    Expression_cluster: WBPaper00029359_1280
      WBPaper00029359_1444
      WBPaper00029359_1504
      WBPaper00029359_1578
      WBPaper00029359_1604
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00040990:PA14_upregulated
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smgl-2(RNAi)_upregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:HgCl2_20uM_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049368:daf-2(e1370)_upregulated
      WBPaper00049495:starvation-refeeding_regulated
      WBPaper00049498:npr-1(ur89)_regulated_1
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
      WBPaper00049635:dop-1(vs100)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050094:mes-6(bn66)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051257:Levamisole_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot267)_downregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00054626:NO_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:male-tail_expressed
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055827:pfd-6(gk493446)_upregulated
      WBPaper00055897:heat-shock_downregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056284:ints-4(RNAi)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056855:his-72(uge40)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_upregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060526:plp-1(ok2155)_downregulated
      WBPaper00060634:fhod-1(tm2363)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-infection_48h_regulated
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061340:ADF_AWB
      WBPaper00061340:ASG
      WBPaper00061340:ASG_AWA
      WBPaper00061340:AWA
      WBPaper00061340:AWC
      WBPaper00061340:CEP
      WBPaper00061340:CEPso
      WBPaper00061340:Excretory_gland
      WBPaper00061340:IL1
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061527:cdc-42_17192-rab-5_18073
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062354:H.zoospora_12h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00062590:Aging_upregulated_coelomocyte
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064532:pals-25(jy111)_downregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00065086:JU1400_N.ausubeli_regulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065926:pgph-2(overepxreesion)_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_5_4
      cgc4489_group_18
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00032948:StarveUp2
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_B
      WBPaper00037695:WC_5-day
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040876:mir-35_downregulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053827:pyoverdine_upregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_SM
    Interaction (18)
  Map_info: Map: I Position: 3.11369 Error: 0.005753
    Positive: Positive_clone: DY3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4889
        4741
    Pseudo_map_position
  Reference: WBPaper00012854
    WBPaper00024548
    WBPaper00038491
    WBPaper00043086
    WBPaper00046423
    WBPaper00055090
    WBPaper00064339
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene