fshr-1 encodes a putative neuropeptide receptor required for normalacetylcholine secretion by synapses; FSHR-1 is orthologous to humanfollicle-stimulating hormone receptor (OMIM:136435; mutated in ovariandysgenesis), thyrotropin receptor (OMIM:603372; mutated inhyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutatedin precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1puncta at synapses, suggesting exocytotic defects; the requirement forFSHR-1 and ten other predicted neuropeptide signalling proteins incholinergic neurotransmission indicates that such signalling isimportant for regulating acetylcholine release at neuromuscularjunctions; possible ligands of FSHR-1 are FLP-1 and NLP-12.
Predicted to enable G protein-coupled peptide receptor activity. Involved in defense response to other organism; response to oxidative stress; and stress response to cadmium ion. Predicted to be located in plasma membrane. Expressed in intestine; neurons; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in several diseases, including cystadenocarcinoma (multiple); disorder of sexual development (multiple); and sex cord-gonadal stromal tumor (multiple). Is an ortholog of human FSHR (follicle stimulating hormone receptor) and LHCGR (luteinizing hormone/choriogonadotropin receptor).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.