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WormBase Tree Display for Gene: WBGene00008239

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Name Class

WBGene00008239SMapS_parentSequenceC50H2
IdentityVersion2
NameCGC_namefshr-1Paper_evidenceWBPaper00026667
Person_evidenceWBPerson1139
Sequence_nameC50H2.1
Molecular_nameC50H2.1a
C50H2.1a.1
CE28214
C50H2.1b
CE48138
C50H2.1b.1
Other_namelgrAccession_evidenceEMBLAF224743
CELE_C50H2.1Accession_evidenceNDBBX284605
Public_namefshr-1
DB_infoDatabaseAceViewgene5K373
WormQTLgeneWBGene00008239
WormFluxgeneWBGene00008239
NDBlocus_tagCELE_C50H2.1
PanthergeneCAEEL|WormBase=WBGene00008239|UniProtKB=L8EC40
familyPTHR24372
NCBIgene179381
RefSeqproteinNM_073147.7
NM_001276924.3
TrEMBLUniProtAccL8EC40
G5EG04
UniProt_GCRPUniProtAccL8EC40
OMIMgene136435
152790
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:48WBPerson1971EventImportedInitial conversion from CDS class of WS125
212 Sep 2005 16:03:13WBPerson2970Name_changeCGC_namefshr-1
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfshr
Allele (65)
StrainWBStrain00031623
WBStrain00007212
RNASeq_FPKM (74)
GO_annotation (18)
Ortholog (51)
ParalogWBGene00011454Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionfshr-1 encodes a putative neuropeptide receptor required for normalacetylcholine secretion by synapses; FSHR-1 is orthologous to humanfollicle-stimulating hormone receptor (OMIM:136435; mutated in ovariandysgenesis), thyrotropin receptor (OMIM:603372; mutated inhyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutatedin precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1puncta at synapses, suggesting exocytotic defects; the requirement forFSHR-1 and ten other predicted neuropeptide signalling proteins incholinergic neurotransmission indicates that such signalling isimportant for regulating acetylcholine release at neuromuscularjunctions; possible ligands of FSHR-1 are FLP-1 and NLP-12.Paper_evidenceWBPaper00026667
Curator_confirmedWBPerson1823
WBPerson567
Date_last_updated09 Nov 2006 00:00:00
Automated_descriptionPredicted to enable G protein-coupled peptide receptor activity. Involved in defense response to other organism; response to oxidative stress; and stress response to cadmium ion. Predicted to be located in plasma membrane. Expressed in intestine; neurons; pharynx; spermatheca; and vulva. Human ortholog(s) of this gene implicated in several diseases, including cystadenocarcinoma (multiple); disorder of sexual development (multiple); and sex cord-gonadal stromal tumor (multiple). Is an ortholog of human FSHR (follicle stimulating hormone receptor) and LHCGR (luteinizing hormone/choriogonadotropin receptor).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (16)
Molecular_infoCorresponding_CDSC50H2.1a
C50H2.1b
Corresponding_CDS_historyC50H2.1:wp52
Corresponding_transcriptC50H2.1a.1
C50H2.1b.1
Other_sequenceJI171853.1
Tcol_isotig10998
JI473293.1
CJC04547_1
Tcol_isotig10997
JI468453.1
Associated_featureWBsf647114
WBsf647115
WBsf661588
WBsf232300
WBsf232301
Experimental_infoRNAi_result (12)
Expr_patternExpr3541
Expr4567
Expr7940
Expr16472
Expr1012556
Expr1033582
Expr1146942
Expr2011911
Expr2030148
Drives_constructWBCnstr00006333
WBCnstr00007211
WBCnstr00007212
WBCnstr00007213
WBCnstr00011465
WBCnstr00013014
WBCnstr00033124
WBCnstr00043063
Construct_productWBCnstr00006333
WBCnstr00007211
WBCnstr00007212
WBCnstr00007213
WBCnstr00020873
WBCnstr00033124
WBCnstr00041283
WBCnstr00041284
WBCnstr00041285
WBCnstr00043063
Regulate_expr_clusterWBPaper00048530:fshr-1(ok778)_PA14_upregulated
WBPaper00048530:fshr-1(ok778)_upregulated
Microarray_results (22)
Expression_clusterWBPaper00031040:TGF-beta_adult_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00038438:S.marcescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00042404:13L-cocoa-peptide_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046509:htz-1(ok3099)_upregulated
WBPaper00048530:fshr-1(ok778)_PA14_upregulated
WBPaper00048530:fshr-1(ok778)_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050080:rbr-2(tm3141)_upregulated
WBPaper00050332:daf-16(RNAi)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:intestine_enriched
WBPaper00051257:Levamisole_upregulated
WBPaper00051404:alg-1(gk214)_downregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_doenregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00056826:hmc_biased
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:ints-4(RNAi)_downregulated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059224:serotonin_downregulated
WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
WBPaper00059839:S.maltophilia_regulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061106:endu-2(tm4977)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061274:hypergravity_15xg_downregulated
WBPaper00061274:microgravity_downregulated
WBPaper00061340:CAN
WBPaper00061341:28C_48h_downregulated
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:gtl-1-hum-8_16432
WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065086:JU1400_N.ausubeli_regulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065086:N2_N.ausubeli_regulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065841:5_0
WBPaper00065841:5_1
WBPaper00065841:37_0
WBPaper00065841:75_0
WBPaper00065841:82_1
WBPaper00065841:141_0
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065984:pals-17(syb3980)_downregulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
WBPaper00066232:ash-2(RNAi)_downregulated_WT
cgc4489_group_25
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00026980:intestine_enriched
WBPaper00030985:Enterococcus_faecalis_downregulated
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00035873:dpy-10_regulated
WBPaper00036123:Atrazine_regulated
WBPaper00036286:Pattern_C
WBPaper00038060:SUMO-1_downregulated
WBPaper00040963:Q200_up
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc6390]:Cluster_B
[cgc6390]:herm_soma-enriched
Interaction (38)
WBProcessWBbiopr:00000039
Map_infoMapVPosition2.20466Error0.001111
PositivePositive_cloneC50H2Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point5520
5436
Pseudo_map_position
Reference (45)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene