WormBase Tree Display for Gene: WBGene00007984

WBGene00007984 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 2
    Name: CGC_name: irx-1 Person_evidence: WBPerson83
            WBPerson3132
            WBPerson1997
      Sequence_name: C36F7.1
      Molecular_name: C36F7.1
        C36F7.1.1
        CE42075
      Other_name: CELE_C36F7.1 Accession_evidence: NDB BX284601
      Public_name: irx-1
    DB_info: Database: AceView gene 1K114
        WormQTL gene WBGene00007984
        WormFlux gene WBGene00007984
        NDB locus_tag CELE_C36F7.1
        Panther gene CAEEL|WormBase=WBGene00007984|UniProtKB=Q93348
          family PTHR11211
        NCBI gene 172789
        RefSeq protein NM_060132.7
        SwissProt UniProtAcc Q93348
        TREEFAM TREEFAM_ID TF319371
        UniProt_GCRP UniProtAcc Q93348
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:48 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 18 Jul 2005 13:34:00 WBPerson2970 Name_change: CGC_name: irx-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: irx
    Allele (42)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP1895
    Ortholog (62)
    Structured_description: Concise_description: irx-1 encodes a homeodomain-containing protein that is most similar to members of the Iroquois subclass of TALE (three amino acid loop extension) superclass atypical homeodomain proteins; IRX-1 functions downstream of the UNC-55 nuclear receptor in a transcriptional regulatory network that controls remodeling of the GABAergic DD neuron synapses during larval development. Paper_evidence: WBPaper00002937
            WBPaper00004402
            WBPaper00024497
            WBPaper00025054
            WBPaper00040363
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Oct 2011 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in head muscle; hypodermis; intestine; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Is an ortholog of several human genes including IRX1 (iroquois homeobox 1); IRX3 (iroquois homeobox 3); and IRX5 (iroquois homeobox 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1682 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14358)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14361)
  Molecular_info: Corresponding_CDS: C36F7.1
    Corresponding_CDS_history: C36F7.1:wp187
    Corresponding_transcript: C36F7.1.1
    Other_sequence: HBC22230_1
      Dviv_isotig23212
      Oden_isotig21744
      JI167499.1
      MHC03189_1
      TX00146
      Hbac_isotig02767
      ES739950.1
      MH06638
    Associated_feature: WBsf649483
      WBsf978267
      WBsf984727
      WBsf984728
      WBsf984729
      WBsf984730
      WBsf1010391
      WBsf1010392
      WBsf1010393
    Transcription_factor: WBTranscriptionFactor000355
  Experimental_info: RNAi_result (18)
    Expr_pattern: Expr7467
      Expr9678
      Expr10339
      Expr15623
      Expr1025765
      Expr1033472
      Expr1146080
      Expr2012868
      Expr2031102
    Drives_construct: WBCnstr00009282
      WBCnstr00012611
      WBCnstr00015265
    Construct_product: WBCnstr00009282
      WBCnstr00009289
      WBCnstr00009290
      WBCnstr00016568
      WBCnstr00021770
    Microarray_results (25)
    Expression_cluster: WBPaper00028867:HLH-1_induced_TF
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00035197:fer-1_downregulated
      WBPaper00037946:LIN-39_interacting
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050094:mes-6(bn66)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051558:aging_regulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053810:sod-2(ok1030)_upregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056167:ifo-1(kc2)_upregulated
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AIB
      WBPaper00061340:AIM
      WBPaper00061340:AMso_parent
      WBPaper00061340:AVG
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Coelomocyte
      WBPaper00061340:Excretory_duct_and_pore
      WBPaper00061340:g2
      WBPaper00061340:G2_and_W_blasts
      WBPaper00061340:g2_parent
      WBPaper00061340:hmc
      WBPaper00061340:hmc_and_homolog
      WBPaper00061340:hmc_homolog
      WBPaper00061340:mc3
      WBPaper00061340:Neuroblast_ASE_ASJ_AUA
      WBPaper00061340:Neuroblast_I6_M5
      WBPaper00061340:Neuroblast_URX_CEPDx
      WBPaper00061340:Parents_of_PHsh_hyp8_hyp9
      WBPaper00061340:Parent_of_exc_duct_pore_DB_1_3
      WBPaper00061340:Pharyngeal_intestinal_valve
      WBPaper00061340:pm6
      WBPaper00061340:pm7
      WBPaper00061340:pm8
      WBPaper00061340:Rectal_cell
      WBPaper00061340:RIC_parent
      WBPaper00061340:RIS
      WBPaper00061466:nath-10(icb99)_upregulated
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061527:sol-1-jnk-1_18695
      WBPaper00062184:PA14_downregulated
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064871:hypoxia_downregulated_F1
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065841:1_2
      WBPaper00065841:34_0
      WBPaper00065841:37_0
      WBPaper00065841:56_0
      WBPaper00065841:62_0
      WBPaper00065841:64_0
      WBPaper00065841:78_0
      WBPaper00065841:96_0
      WBPaper00065841:117_0
      WBPaper00065841:123_0
      WBPaper00065841:126_0
      WBPaper00065841:128_0
      WBPaper00065841:131_0
      WBPaper00065841:135_0
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      cgc4386_cluster_6_5
      WBPaper00025032:cluster_12
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030985:Enterococcus_faecalis_downregulated
      WBPaper00030985:Photorhabdus_luminescens_downregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031003:hlh_1_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040963:Q50_down
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045960:L1-L4-lethargus_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_5
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_SE
      [cgc5767]:expression_class_SE_pi(23_min)
    Interaction (34)
  Map_info: Map: I Position: 3.80092 Error: 0.000995
    Positive: Positive_clone: C36F7 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5375
        4148
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene