WormBase Tree Display for Gene: WBGene00006964
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| WBGene00006964 | SMap | S_parent | Sequence | Y48B6A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | xrn-2 | Paper_evidence | WBPaper00026763 | |||||
| Sequence_name | Y48B6A.3 | ||||||||
| Molecular_name | Y48B6A.3 | ||||||||
| Y48B6A.3.1 | |||||||||
| CE42702 | |||||||||
| Other_name | CELE_Y48B6A.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | xrn-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 17 Sep 2004 10:19:03 | WBPerson1971 | Name_change | CGC_name | xrn-1 name removed | ||||
| 3 | 14 Sep 2006 10:20:52 | WBPerson2970 | Name_change | CGC_name | xrn-2 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | xrn | ||||||||
| Allele (227) | |||||||||
| Strain | WBStrain00002577 | ||||||||
| In_cluster | conserved_miRNA_siRNA_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Contained_in_operon | CEOP2697 | ||||||||
| Ortholog (41) | |||||||||
| Paralog | WBGene00013153 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | |||||
| WBGene00012730 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | xrn-2 encodes a 5'-3' exoribonuclease orthologous to Saccharomyces cerevisiae Rat1p; XRN-2 activity is required for degradation and hence regulation of levels of mature miRNAs such as let-7; accordingly, loss of xrn-2 activity affects miRNA-mediated processes such as molting, specifically shedding cuticle from the pharynx, and regulation of vulval development; an xrn-2::gfp promoter fusion is expressed in the pharyngeal myoepithelium, the intestine, and neurons. | Paper_evidence | WBPaper00026763 | |||||
| WBPaper00035168 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Mar 2010 00:00:00 | ||||||||
| Automated_description | Enables 5'-3' RNA exonuclease activity. Involved in several processes, including miRNA catabolic process; negative regulation of miRNA-mediated gene silencing; and regulation of vulval development. Located in nucleus. Expressed in M5 neuron; PVT; intestine; and pharyngeal epithelial cell. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; leiomyosarcoma; and lung cancer. Is an ortholog of human XRN2 (5'-3' exoribonuclease 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1967 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12836) | ||||
| DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12836) | ||||||
| DOID:0080202 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12836) | ||||||
| Molecular_info | Corresponding_CDS | Y48B6A.3 | |||||||
| Corresponding_CDS_history | Y48B6A.3:wp191 | ||||||||
| Corresponding_transcript | Y48B6A.3.1 | ||||||||
| Other_sequence (36) | |||||||||
| Associated_feature | WBsf658391 | ||||||||
| WBsf658392 | |||||||||
| WBsf658393 | |||||||||
| WBsf990645 | |||||||||
| WBsf222428 | |||||||||
| Experimental_info | RNAi_result (36) | ||||||||
| Expr_pattern | Chronogram1895 | ||||||||
| Expr3697 | |||||||||
| Expr11496 | |||||||||
| Expr1018600 | |||||||||
| Expr1032975 | |||||||||
| Expr1160333 | |||||||||
| Expr2018111 | |||||||||
| Expr2036249 | |||||||||
| Drives_construct | WBCnstr00003136 | ||||||||
| WBCnstr00006894 | |||||||||
| WBCnstr00011608 | |||||||||
| WBCnstr00018878 | |||||||||
| WBCnstr00018879 | |||||||||
| WBCnstr00018880 | |||||||||
| WBCnstr00018881 | |||||||||
| WBCnstr00018882 | |||||||||
| WBCnstr00019051 | |||||||||
| WBCnstr00020324 | |||||||||
| Construct_product | WBCnstr00018878 | ||||||||
| WBCnstr00018879 | |||||||||
| WBCnstr00018880 | |||||||||
| WBCnstr00018881 | |||||||||
| WBCnstr00018882 | |||||||||
| Antibody | WBAntibody00002503 | ||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (56) | |||||||||
| Map_info | Map | II | Position | 22.4642 | Error | 0.003721 | |||
| Positive | Positive_clone | Y48B6A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (26) | |||||||||
| Remark (2) | |||||||||
| Method | Gene |
