| WBGene00006779 | SMap | S_parent | Sequence | CHROMOSOME_IV |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-43 | Person_evidence | WBPerson261 |
| | | Sequence_name | K11E8.1 |
| | | Molecular_name (61) |
| | | Other_name | dec-8 |
| | | | CELE_K11E8.1 | Accession_evidence | NDB | BX284604 |
| | | Public_name | unc-43 |
| | DB_info | Database (15) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143187 |
| | Allele | WBVar00249012 | Inferred_automatically | From strain object: CG118 |
| | | | | From strain object: CG460 |
| | | WBVar00242519 | Inferred_automatically | From strain object: JT200 |
| | | WBVar00090003 | Inferred_automatically | From strain object: MT2598 |
| | | WBVar00601269 | Inferred_automatically | From strain object: NM1378 |
| | | WBVar00089497 | Inferred_automatically | From strain object: PJ1270 |
| | | WBVar01474470 | Inferred_automatically | From strain object: PJ1305 |
| | | WBVar00143459 |
| | | WBVar00089554 |
| | | WBVar00090008 |
| | | WBVar00090004 |
| | | WBVar00296262 |
| | | WBVar00089555 |
| | | WBVar00090011 |
| | | WBVar00090012 |
| | | WBVar00143074 |
| | | WBVar00937030 |
| | | WBVar00937031 |
| | | WBVar00937032 |
| | | WBVar00937033 |
| | | WBVar00937034 |
| | | WBVar00937035 |
| | | WBVar00937036 |
| | | WBVar00937037 |
| | | WBVar00937038 |
| | | WBVar00937039 |
| | | WBVar00937040 |
| | | WBVar01500079 |
| | | WBVar00937041 |
| | | WBVar00937042 |
| | | WBVar00937043 |
| | | WBVar00937044 |
| | | WBVar00937045 |
| | | WBVar00260768 |
| | | WBVar00937046 |
| | | WBVar00937047 |
| | | WBVar00937048 |
| | | WBVar01491070 |
| | | WBVar00937049 |
| | | WBVar00937050 |
| | | WBVar00937051 |
| | | WBVar00937052 |
| | | WBVar00937053 |
| | | WBVar00937054 |
| | | WBVar00251750 |
| | | WBVar00937055 |
| | | WBVar00937056 |
| | | WBVar00937057 |
| | | WBVar00937058 |
| | | WBVar00937059 |
| | | WBVar00937060 |
| | | WBVar00937061 |
| | | WBVar00937062 |
| | | WBVar01498996 |
| | | WBVar00145857 |
| | | WBVar00937063 |
| | | WBVar00937064 |
| | | WBVar00937065 |
| | | WBVar00937066 |
| | | WBVar02125310 |
| | | WBVar00937067 |
| | | WBVar02125311 |
| | | WBVar00245639 |
| | | WBVar00937068 |
| | | WBVar00937069 |
| | | WBVar00433851 |
| | | WBVar02037084 |
| | | WBVar00937070 |
| | | WBVar00433852 |
| | | WBVar02037085 |
| | | WBVar00433853 |
| | | WBVar01499925 |
| | | WBVar00937071 |
| | | WBVar00433854 |
| | | WBVar02037086 |
| | | WBVar00937072 |
| | | WBVar00433855 |
| | | WBVar00937073 |
| | | WBVar02037087 |
| | | WBVar00937074 |
| | | WBVar00433856 |
| | | WBVar00937075 |
| | | WBVar00433857 |
| | | WBVar00937076 |
| | | WBVar00258591 |
| | | WBVar00433858 |
| | | WBVar00433859 |
| | | WBVar00937077 |
| | | WBVar00433860 |
| | | WBVar00937078 |
| | | WBVar00433861 |
| | | WBVar00937079 |
| | | WBVar00090005 |
| | | WBVar00249013 |
| | | WBVar00258595 |
| | | WBVar00090006 |
| | | WBVar00433862 |
| | | WBVar00937080 |
| | | WBVar00249014 |
| | | WBVar00433863 |
| | | WBVar00090007 |
| | | WBVar00937081 |
| | | WBVar00937082 |
| | | WBVar00090009 |
| | | WBVar00433864 |
| | | WBVar00090010 |
| | | WBVar00433865 |
| | | WBVar00937083 |
| | | WBVar00433866 |
| | | WBVar00937084 |
| | | WBVar00090034 |
| | | WBVar00937085 |
| | | WBVar00433867 |
| | | WBVar00433868 |
| | | WBVar00937086 |
| | | WBVar00433869 |
| | | WBVar00937087 |
| | | WBVar00433870 |
| | | WBVar00937088 |
| | | WBVar00937089 |
| | | WBVar00433871 |
| | | WBVar00937090 |
| | | WBVar00433872 |
| | | WBVar00433873 |
| | | WBVar02114955 |
| | | WBVar00937091 |
| | | WBVar00937092 |
| | | WBVar00433874 |
| | | WBVar00937093 |
| | | WBVar01795266 |
| | | WBVar00433875 |
| | | WBVar01795267 |
| | | WBVar00433876 |
| | | WBVar00937094 |
| | | WBVar00433877 |
| | | WBVar01795268 |
| | | WBVar00937095 |
| | | WBVar01795269 |
| | | WBVar00433878 |
| | | WBVar00937096 |
| | | WBVar01795270 |
| | | WBVar00433879 |
| | | WBVar00937097 |
| | | WBVar01795271 |
| | | WBVar00937098 |
| | | WBVar00433880 |
| | | WBVar00937099 |
| | | WBVar00433881 |
| | | WBVar01795272 |
| | | WBVar00433882 |
| | | WBVar01818849 |
| | | WBVar01795273 |
| | | WBVar00937100 |
| | | WBVar01482290 |
| | | WBVar00433883 |
| | | WBVar01795274 |
| | | WBVar00937101 |
| | | WBVar00937102 |
| | | WBVar01482291 |
| | | WBVar01795275 |
| | | WBVar02122143 |
| | | WBVar00433884 |
| | | WBVar01795276 |
| | | WBVar00937103 |
| | | WBVar01482292 |
| | | WBVar00433885 |
| | | WBVar02122144 |
| | | WBVar00937104 |
| | | WBVar01795277 |
| | | WBVar00433886 |
| | | WBVar01795278 |
| | | WBVar00937105 |
| | | WBVar00433887 |
| | | WBVar01795279 |
| | | WBVar00433888 |
| | | WBVar00937106 |
| | | WBVar00937107 |
| | | WBVar00433889 |
| | | WBVar01795280 |
| | | WBVar01795281 |
| | | WBVar00433890 |
| | | WBVar00937108 |
| | | WBVar00433891 |
| | | WBVar00937109 |
| | | WBVar00433892 |
| | | WBVar00937110 |
| | | WBVar00937111 |
| | | WBVar02058655 |
| | | WBVar00433893 |
| | | WBVar02058656 |
| | | WBVar00309117 |
| | | WBVar00089553 |
| | | WBVar00937112 |
| | | WBVar00433894 |
| | | WBVar00316687 |
| | | WBVar00937113 |
| | | WBVar00433895 |
| | | WBVar02058657 |
| | | WBVar00937114 |
| | | WBVar00433896 |
| | | WBVar02058658 |
| | | WBVar00937115 |
| | | WBVar02058659 |
| | | WBVar02058660 |
| | | WBVar00937116 |
| | | WBVar00937117 |
| | | WBVar02058661 |
| | | WBVar00937118 |
| | | WBVar02058662 |
| | | WBVar02058663 |
| | | WBVar00937119 |
| | | WBVar00937120 |
| | | WBVar01494085 |
| | | WBVar00937121 |
| | | WBVar00937122 |
| | | WBVar00937123 |
| | | WBVar00276959 |
| | | WBVar00937124 |
| | | WBVar00937125 |
| | | WBVar01453910 |
| | | WBVar00276961 |
| | | WBVar00937126 |
| | | WBVar01453912 |
| | | WBVar01453913 |
| | | WBVar00937127 |
| | | WBVar00937128 |
| | | WBVar01453914 |
| | | WBVar00937129 |
| | | WBVar01453915 |
| | | WBVar00937130 |
| | | WBVar01453916 |
| | | WBVar01453917 |
| | | WBVar00937131 |
| | | WBVar00937132 |
| | | WBVar00937133 |
| | | WBVar00937134 |
| | | WBVar02134542 |
| | | WBVar00937135 |
| | | WBVar00937136 |
| | | WBVar01497413 |
| | | WBVar00191780 |
| | | WBVar01856864 |
| | | WBVar00937137 |
| | | WBVar00937138 |
| | | WBVar00191781 |
| | | WBVar01856865 |
| | | WBVar01856866 |
| | | WBVar00191782 |
| | | WBVar00937139 |
| | | WBVar00937140 |
| | | WBVar01856867 |
| | | WBVar00191783 |
| | | WBVar00191784 |
| | | WBVar01856868 |
| | | WBVar01549010 |
| | | WBVar00937141 |
| | | WBVar00191785 |
| | | WBVar00937142 |
| | | WBVar01856869 |
| | | WBVar01856870 |
| | | WBVar00937143 |
| | | WBVar02046050 |
| | | WBVar00937144 |
| | | WBVar01856871 |
| | | WBVar01856872 |
| | | WBVar00937145 |
| | | WBVar01856873 |
| | | WBVar00937146 |
| | | WBVar00937147 |
| | | WBVar01856874 |
| | | WBVar00937148 |
| | | WBVar01856875 |
| | | WBVar00937149 |
| | | WBVar01856876 |
| | | WBVar01856877 |
| | | WBVar00937150 |
| | | WBVar01856878 |
| | | WBVar01856879 |
| | | WBVar01856880 |
| | | WBVar01491910 |
| | | WBVar02034543 |
| | | WBVar01856881 |
| | | WBVar01856882 |
| | | WBVar01856883 |
| | | WBVar01856884 |
| | | WBVar01856885 |
| | | WBVar01856886 |
| | | WBVar01856887 |
| | | WBVar01856888 |
| | | WBVar01856889 |
| | | WBVar01856890 |
| | | WBVar00253155 |
| | | WBVar00251675 |
| | | WBVar01856891 |
| | | WBVar01856892 |
| | | WBVar02021117 |
| | | WBVar01856893 |
| | | WBVar01499653 |
| | | WBVar01856894 |
| | | WBVar02021118 |
| | | WBVar00142755 |
| | | WBVar01856895 |
| | | WBVar01786467 |
| | | WBVar00143187 |
| | | WBVar01856896 |
| | | WBVar01786468 |
| | | WBVar01730662 |
| | | WBVar00253346 |
| | | WBVar01856897 |
| | | WBVar01856898 |
| | | WBVar01730663 |
| | | WBVar01856899 |
| | | WBVar01730664 |
| | | WBVar01856900 |
| | | WBVar01856901 |
| | | WBVar01856902 |
| | | WBVar01856903 |
| | | WBVar01856904 |
| | | WBVar01856905 |
| | | WBVar01856906 |
| | | WBVar00250586 |
| | | WBVar01668802 |
| | | WBVar00937003 |
| | | WBVar00937004 |
| | | WBVar00937005 |
| | | WBVar00937006 |
| | | WBVar00250966 |
| | | WBVar00937007 |
| | | WBVar00937008 |
| | | WBVar00937009 |
| | | WBVar00937010 |
| | | WBVar00937011 |
| | | WBVar00306862 |
| | | WBVar00937012 |
| | | WBVar01896616 |
| | | WBVar00937013 |
| | | WBVar00937014 |
| | | WBVar01896617 |
| | | WBVar00937015 |
| | | WBVar00937016 |
| | | WBVar00255400 |
| | | WBVar00937017 |
| | | WBVar00937018 |
| | | WBVar00937019 |
| | | WBVar00937020 |
| | | WBVar01398340 |
| | | WBVar00937021 |
| | | WBVar00937022 |
| | | WBVar01500245 |
| | | WBVar00937023 |
| | | WBVar00937024 |
| | | WBVar00260747 |
| | | WBVar00937025 |
| | | WBVar00937026 |
| | | WBVar01495279 |
| | | WBVar00937027 |
| | | WBVar00937028 |
| | | WBVar00937029 |
| | Legacy_information | e408 : slow slightly rippling movement poor backing thin; old adults Egl almost paralysed tend to shrink and relax when prodded; larvae move better. ES3 (adult) ME0. NA3 (e266 e755). |
| | | Also gain-of-function allele n498sd : paralysed n498/+ less severe; revertants e.g. n498n1179 have recessive uncoordinated phenotype. |
| | | See also e408, n498, n1179, n1180, n1181, n1182, n1183, n1184, n1185, n1186, n1187, n1188, n1210 |
| | | [Reiner D]] Mac-m (Muscle ACtivation-Mixed) |
| | | [Reiner D] n498sd is Daf-c at 27C. |
| | | [Reiner D] The egg-laying phenotype of loss-of-function unc-43mutations is strong egg laying constitutive, where animals lay eggs of a very early stage. All unc-43 loss-of-function alleles confer echo defecation cycles: reiterated activation of motor program components. Furthermore, unc-43(lof) mutations have defects in locomotion motivation. The are lazy (motionless), followed by sharp jerks of the body. |
| | | [C.elegansII] e408 : slow, lazy, slightly rippling movement poor backing thin; almost paralysed, tends to shrink and relax when prodded; larvae move better; Egl-c.ES3 (adult) ME1. OA>5: e266 (similar Unc, Egl-c, echo in defecation cycle; exhibits muscle activation defects in some tissues, muscle hyperactivation in others), e300 (shorter than e408, shrinking more marked), e755, sa200 (pka dec-8, weaker allele, Dec non-Unc;sa200/Df is Unc). Also gain-of-function allele: n498sd small, almost paralysed, Egl; Daf-c at 27C; n498/+ less severe). Intragenic revertants e.g. n498n1179 have recessive uncoordinated phenotype. [Park and Horvitz 1986; JT] |
| | Strain (15) |
| | RNASeq_FPKM (74) |
| | GO_annotation (42) |
| | Ortholog (51) |
| | Paralog (14) |
| | Structured_description | Concise_description | unc-43 encodes the C. elegans ortholog of type II calcium/calmodulin-dependent protein kinase (CaMKII); unc-43 activity is required for a number of processes, including locomotion, neuronal cell fate specification and regulation of synaptic density, egg laying, defecation, and meiotic maturation; in regulating some of these processes, unc-43 acts in concert with MAPKKK and G protein signaling pathways; UNC-43 is expressed in neurons, oocytes, and gonadal sheath cells; UNC-43 can regulate the activity of the EGL-2 ether-a-go-go potassium channel with which it physically interacts. | Paper_evidence (11) |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 09 Feb 2011 00:00:00 |
| | | Automated_description | Enables calmodulin-dependent protein kinase activity; identical protein binding activity; and transmembrane transporter binding activity. Involved in MAPK cascade; medium-term memory; and positive regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm. Expressed in several structures, including AWC; copulatory spicule; gonadal sheath cell; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; intellectual disability (multiple); and malignant astrocytoma. Is an ortholog of human CAMK2D (calcium/calmodulin dependent protein kinase II delta). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1463) |
| | | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1460) |
| | | DOID:0080230 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1461) |
| | | DOID:3070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1460) |
| | | DOID:3069 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1463) |
| | | DOID:0081224 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1460) |
| | | DOID:0080228 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1460) |
| Molecular_info | Corresponding_CDS (18) |
| | Corresponding_CDS_history | K11E8.1a:wp52 |
| | | K11E8.1a:wp191 |
| | | K11E8.1b:wp52 |
| | | K11E8.1c:wp52 |
| | | K11E8.1c:wp229 |
| | Corresponding_transcript (25) |
| | Other_sequence (69) |
| | Associated_feature (45) |
| Experimental_info | RNAi_result (16) |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00001323 |
| | | WBCnstr00002569 |
| | | WBCnstr00012386 |
| | | WBCnstr00018122 |
| | | WBCnstr00018123 |
| | Construct_product (16) |
| | Antibody | WBAntibody00000248 |
| | Microarray_results (140) |
| | Expression_cluster (221) |
| | Interaction (196) |
| | Anatomy_function | WBbtf0509 |
| | | WBbtf0511 |
| | | WBbtf0512 |
| | | WBbtf0513 |
| | | WBbtf1063 |
| | WBProcess | WBbiopr:00000010 |
| | | WBbiopr:00000039 |
| Map_info | Map | IV | Position | 4.57616 | Error | 0.00067 |
| | Well_ordered |
| | Positive | Positive_clone | K11E8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 114 |
| | | | 453 |
| | | | 631 |
| | | Multi_point (21) |
| | | Pos_neg_data (13) |
| | Landmark_gene |
| Reference (217) |
| Picture | WBPicture0000013079 |
| Method | Gene |
