WormBase Tree Display for Gene: WBGene00006759

WBGene00006759 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 3
    Name: CGC_name: unc-22 Person_evidence: WBPerson261
      Sequence_name: ZK617.1
      Molecular_name (27)
      Other_name: twitchin kinase Paper_evidence: WBPaper00002642
        twitchin Paper_evidence: WBPaper00031595
        CELE_ZK617.1 Accession_evidence: NDB BX284604
      Public_name: unc-22
    DB_info: Database (15)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 23 Feb 2010 15:11:48 WBPerson4025 Event: Acquires_merge: WBGene00014010
        3 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303099
      Acquires_merge: WBGene00014010
      Split_into: WBGene00303099
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142944
    Allele (644)
    Legacy_information: e66 : twitcher at all stages; (moves slowly with constant trembling); thin; unable to hypercontract and therefore levamisole resistant; Egl; e66/+ twitches in 1% nicotine; ES3 ME0. NA > 200 (s32amber (resembles e66); m52dm; many Tc1 insertions etc.). Most unc-22/+ heterozygotes twitch in nicotine; abnormal muscle structure in most homozygotes; near normal muscle for alleles e105 s12 Tc1 induced alleles. See also unc-54.
      See also e66, e105, e308, e313, e320, e346, e640, e654, e682, e683, e691, e842, e855, e882, e913, e914, e915, e991, e1090, e1179, e1326, e1923, e2092, e2147, e2148, e2174, e2182, e2377, e2378, e2428, n789, n790, n791, n792, n793, s7, s8, s11, s12, s13, s14, s15, s16, s17, s18, s19, s20, s21, s22, s23, s24, s25, s28, s32, s34, s35, s36, s55, s56, s67, s135, s162, s164, s165, s183, s184, s264, s265, s266, s278, s279, s280, s281, s282, s283, s284, s285, s289, s292, s293, s294, s295, s296, s297, s298, s299, s300, s301, s302, s303, s304, s305, s306, s307, s308, s309, s310, s311, s312, s313, s314, s315, s316, s699, s700, s705, s724, s727, s1787, s1788, s1790, s1791, s1792, s1793, s2028, s2029, s2030, s2038, st136, st137, st192
      [C.elegansII] e66 : twitcher at all stages; (moves slowly with constant trembling); thin; abnormal muscle structure; unable to hypercontract and therefore levamisole resistant; Egl; e66/+ twitches in 1% nicotine; ES3 ME0. OA>200:s32amb (resembles e66), m52dm,e105 (muscle structure near normal),e2428, s7, s12 (near normal muscle structure),s2038,st192 etc. Many Tc1 insertions, plus precise and imprecise excision revertants. Most unc-22/+ heterozygotes twitch in nicotine. Cloned: large gene (>30 kb), transcript ~19 kb,encodes 6049 aa twitchin: single kinase domain, multiple copies of fibronectin-like and Ig-like repeats. Antibody staining indicates twitchin associated with thick filaments. [Waterston et al. 1980; Benian et al. 1989, 1993; GB]
    Strain (134)
    RNASeq_FPKM (74)
    GO_annotation (30)
    Ortholog (42)
    Paralog (12)
    Structured_description: Concise_description: unc-22 encodes twitchin, a giant intracellular protein with multiple fibronectin- and immunoglobulin-like domains and a single protein kinase domain that is homologous to titin (OMIM:188840); UNC-22 is required in muscle for regulation of the actomyosin contraction-relaxation cycle and for maintenance of normal muscle morphology; UNC-22 associates with myosin and is localized to A-bands; in vitro, UNC-22 can phosphorylate myosin light-chain peptides and can undergo autophosphorylation. Paper_evidence: WBPaper00001203
            WBPaper00001773
            WBPaper00005546
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including adult behavior; positive regulation of sarcomere organization; and positive regulation of striated muscle contraction. Located in A band. Expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2J; coronary artery disease; intrinsic cardiomyopathy (multiple); and tibial muscular dystrophy. Is an ortholog of human TTN (titin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111188 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110430 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0111078 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0110315 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:0081341 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:12930 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12403)
  Molecular_info: Corresponding_CDS: ZK617.1a
      ZK617.1b
      ZK617.1c
      ZK617.1d
      ZK617.1e
      ZK617.1f
      ZK617.1g
      ZK617.1h
      ZK617.1i
    Corresponding_CDS_history: ZK617.1a:wp92
      ZK617.1b:wp92
      ZK617.1c:wp229
      ZK617.1d:wp243
      ZK617.1j:wp264
    Corresponding_transcript: ZK617.1a.1
      ZK617.1b.1
      ZK617.1c.1
      ZK617.1d.1
      ZK617.1e.1
      ZK617.1f.1
      ZK617.1g.1
      ZK617.1h.1
      ZK617.1i.1
    Other_sequence (86)
    Associated_feature (32)
  Experimental_info: RNAi_result (41)
    Expr_pattern: Expr13345
      Expr13346
      Expr13347
      Expr13348
      Expr1013173
      Expr1032832
      Expr1162974
      Expr2017855
      Expr2035991
    Drives_construct: WBCnstr00039209
      WBCnstr00039210
      WBCnstr00039211
      WBCnstr00039212
    Construct_product: WBCnstr00001720
      WBCnstr00001721
      WBCnstr00001722
      WBCnstr00001723
      WBCnstr00001724
      WBCnstr00015909
    Antibody: WBAntibody00001511
      WBAntibody00001778
    Microarray_results (53)
    Expression_cluster: WBPaper00027339:daf-12(rh273)_upregulated
      WBPaper00028451:Oogenic_protein
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040209:B.thuringiensis_upregulated_MY15
      WBPaper00040285:H2S_12hr_downregulated
      WBPaper00040285:H2S_24hr_downregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044578:reduced-humidity_downregulated_microarray
      WBPaper00044736:flat_dev_expression
      WBPaper00044746:aging_downregulated_HeatShock
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045693:S.flexneri_upregulated
      WBPaper00045971:tunicamycin_upregulated_control
      WBPaper00046446:rapid-synthesized_AgingAdult
      WBPaper00046446:slow-synthesized_YoungAdult
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046795:starvation_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048988:neuron_expressed
      WBPaper00049377:MWCNT_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049920:hyl-2(tm2031)_upregulated
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050015:ifg-1(RNAi)_upregulated
      WBPaper00050053:muscle_enriched_Day4
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:cytoplasm_specific
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_24h_regulated
      WBPaper00053318:Aging_downregulated_mRNA_N2
      WBPaper00053321:mes-4(RNAi)_downregulated_fed-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00053888:drh-3(rrr2)_downregulated
      WBPaper00054189:P.aeruginosa_regulated_protein
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:Tunicamycin_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055969:electromagnetic-field_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
      WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_downregulated_miRNA-target
      WBPaper00057154:HeatShock_upregulated_mRNA
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058711:paraquat_upregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059231:alh-6(lax105)_D3Adult_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060526:plp-1(ok2155)_upregulated
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060871:M.humicola-extract_4h_regulated
      WBPaper00060908:TEBP-1_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00061040:FW1256_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061390:daf-22(ok693)_ascarosides_upregulated
      WBPaper00061466:nath-10(icb99)_upregulated
      WBPaper00061466:nath-10(icb102)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:F49E2.5_8378-anc-1_2769
      WBPaper00061527:tnt-4-myo-1_2160
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062167:mbl-1(tm1563)_downregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:etr-1(lq61)_upregulated
      WBPaper00062440:crh-1(n3315)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064055:trl-1(cas1078)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064122:vulva_transcriptome
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064624:iHg-induced_aggregome
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064769:him-17(me24)_upregulated
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065086:N2_N.ferruginous_regulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:53
      WBPaper00065623:97
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:1_1
      WBPaper00065841:4_0
      WBPaper00065841:4_1
      WBPaper00065841:4_2
      WBPaper00065841:7_0
      WBPaper00065841:7_1
      WBPaper00065841:7_2
      WBPaper00065841:7_3
      WBPaper00065841:7_4
      WBPaper00065841:24_1
      WBPaper00065841:26_0
      WBPaper00065841:38_0
      WBPaper00065841:38_1
      WBPaper00065841:38_2
      WBPaper00065841:38_3
      WBPaper00065841:102_0
      WBPaper00065841:110_0
      WBPaper00065841:143_0
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_20
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00031003:0hr_muscle_enriched
      WBPaper00031003:24hr_muscle_enriched
      WBPaper00031003:total_muscle_enriched
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00034661:AgNPs_downregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_48h
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045865:biofilm_downregulated_B
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00049311:AgNO3_regulated
      WBPaper00049311:sAg-MNP_regulated
      WBPaper00051387:Triclosan_upregulated
      [cgc6390]:Cluster_C
    Interaction (67)
  Map_info: Map: IV Position: 5.45802 Error: 0.005203
    Well_ordered
    Positive: Inside_rearr: nDf28
        sDf8
      Positive_clone: LDM17
        YK1088
        ZK617 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: sDf22
        mDp4
    Mapping_data: 2_point (67)
      Multi_point (125)
      Pos_neg_data (38)
    Landmark_gene
  Reference (371)
  Remark: yk16f10.3 removed from sequence list. sdm 11/00
  Method: Gene