| WBGene00006649 | Evidence | Person_evidence | WBPerson463 |
|---|
| SMap | S_parent | Sequence | F08F1 |
| Identity | Version | 1 |
| | Name | CGC_name | tth-1 | Person_evidence | WBPerson463 |
| | | Sequence_name | F08F1.8 |
| | | Molecular_name | F08F1.8 |
| | | | F08F1.8.1 |
| | | | CE27929 |
| | | | F08F1.8.2 |
| | | Other_name | CELE_F08F1.8 | Accession_evidence | NDB | BX284606 |
| | | Public_name | tth-1 |
| | DB_info | Database | AceView | gene | XJ42 |
| | | | WormQTL | gene | WBGene00006649 |
| | | | WormFlux | gene | WBGene00006649 |
| | | | NDB | locus_tag | CELE_F08F1.8 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006649|UniProtKB=O17389 |
| | | | | family | PTHR20940 |
| | | | NCBI | gene | 181097 |
| | | | RefSeq | protein | NM_077029.5 |
| | | | SwissProt | UniProtAcc | O17389 |
| | | | TREEFAM | TREEFAM_ID | TF313856 |
| | | | UniProt_GCRP | UniProtAcc | O17389 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | tth |
| | Allele (26) |
| | Strain | WBStrain00035517 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00029709 |
| | | 00029710 |
| | | 00029711 |
| | | 00029712 |
| | | 00029713 |
| | | 00029714 |
| | | 00029715 |
| | | 00029716 |
| | | 00029717 |
| | | 00029718 |
| | | 00114541 |
| | | 00114542 |
| | Contained_in_operon | CEOPX100 |
| | Ortholog (23) |
| | Structured_description | Concise_description | tth-1 encodes a thymosin beta ortholog that contains four functionally distinct thymosin beta repeats; in vitro, TTH-1 binds multiple actin monomers as well as filamentous actin suggesting that, as its homology predicts, TTH-1 plays a direct role in regulating actin polymerization and cytoskeletal organization in C. elegans; consistent with this, loss of tth-1 activity via a deletion mutation that removes upstream sequences results in animals with a dumpy morphology that are sterile as a result of maternal effect lethality associated with deformed oocytes containing abnormally distributed actin; tth-1 mRNA is present throughout development, while TTH-1 protein is detected in the adult gonad in the inside edges of the membranous structures surrounding germline nuclei, the cytoplasm and cortex of oocytes, early embryos at points of cell contact, the developing nerve ring, and then throughout the larval and adult body, with specific enrichment in the intestine and spermatheca. | Paper_evidence | WBPaper00023907 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 22 Nov 2005 00:00:00 |
| | | Automated_description | Predicted to enable actin monomer binding activity. Predicted to be involved in actin filament organization. Predicted to be located in cytosol. Expressed in distal tip cell; nerve ring; oocyte; spermatheca; and terminal bulb. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F08F1.8 |
| | Corresponding_transcript | F08F1.8.1 |
| | | F08F1.8.2 |
| | Other_sequence | CJC05583_1 |
| | | CRC01301_1 |
| | | CBC14720_1 |
| | | CR06649 |
| | | CR02116 |
| | Associated_feature | WBsf670840 |
| | | WBsf1006146 |
| Experimental_info | RNAi_result | WBRNAi00044013 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00012902 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00033485 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr5681 |
| | | Expr12264 |
| | | Expr12265 |
| | | Expr1016059 |
| | | Expr1032763 |
| | | Expr1147980 |
| | | Expr2017564 |
| | | Expr2035703 |
| | Drives_construct | WBCnstr00034239 |
| | Construct_product | WBCnstr00034239 |
| | Antibody | WBAntibody00001843 |
| | Microarray_results (19) |
| | Expression_cluster | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00038357:atx-3_regulated_heat-shock |
| | | WBPaper00040412:germline-regulated_daf-16_target |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_Day5 |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045390:tunicamycin_downregulated |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00045774:clk-1_upregulated_CoQ10_dependent |
| | | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated |
| | | WBPaper00046337:polysomal_N2_vs_daf-2_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_upregulated_protein |
| | | WBPaper00046509:htz-1(ok3099)_upregulated |
| | | WBPaper00046795:starvation_upregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049495:starvation-refeeding_regulated |
| | | WBPaper00049498:npr-1(ur89)_regulated_5 |
| | | WBPaper00049635:dop-1(vs100)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049905:Age_variant_expression |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050332:daf-16(RNAi)_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050448:KGB-1-induced |
| | | WBPaper00050468:hlh-30-dependent_Cry5B_regulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051137:Orsay-virus_upregulated_rde-1(ne219) |
| | | WBPaper00051265:F4_hrde-1(tm1200)_downregulated |
| | | WBPaper00051265:F4_morc-1(tm6048)_downregulated |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053318:mir-71(n4115)_upregulated_mRNA |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_upregulated |
| | | WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated |
| | | WBPaper00053810:daf-2(e1370)_upregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00054872:egl-9(sa307)_upregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055941:atfs-1(et15)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056167:Cry5B_downregulated |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057143:ztf-11(RNAi)_upregulated |
| | | WBPaper00057154:HeatShock_downregulated_miRNA-target |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059537:ngn-1(ok2200)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059895:wounding_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060703:nas-38(ok3407)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061007:X.citri_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:G2_and_W_blasts |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:GLR |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:ILsh_OLLsh_OLQsh |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V |
| | | WBPaper00061340:Pharyngeal_intestinal_valve |
| | | WBPaper00061340:pm1_pm2 |
| | | WBPaper00061340:pm8 |
| | | WBPaper00061340:Posterior_arcade_cell |
| | | WBPaper00061340:RID |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061527:F13E6.1_2090-C35C5.3_1843 |
| | | WBPaper00061527:T12G3.1_17-T12G3.1_18846 |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061651:AMso_enriched |
| | | WBPaper00061651:hmc_enriched |
| | | WBPaper00061651:PHso_enriched |
| | | WBPaper00061651:Spermatheca_enriched |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00061902:camt-1(ok515)_regulated_AFD |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062184:PA14_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062237:dnj-21(RNAi)_upregulated_protein |
| | | WBPaper00062293:clk-1(qm30)_upregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13) |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062587:lsl-1(ljm1)_upregulated |
| | | WBPaper00062587:lsl-1(tm4769)_upregulated |
| | | WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated |
| | | WBPaper00062684:pathogen_upregulated_N2 |
| | | WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA |
| | | WBPaper00064005:starvation_downregulated_N2_mRNA |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064788:ketamine_upregulated |
| | | WBPaper00064789:Day9_vs_Day1_upregulated_neuron |
| | | WBPaper00064789:Day12_vs_Day1_upregulated_neuron |
| | | WBPaper00064871:hypoxia_downregulated_F3 |
| | | WBPaper00064871:PA14_upregulated_AWA |
| | | WBPaper00065086:N2_N.ausubeli_regulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065835:Day5_vs_Day1_upregulated |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:11_2 |
| | | WBPaper00065841:11_3 |
| | | WBPaper00065841:34_0 |
| | | WBPaper00065841:34_1 |
| | | WBPaper00065841:64_0 |
| | | WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_WT |
| | | cgc4386_cluster_6_2 |
| | | cgc4489_group_17 |
| | | WBPaper00024393:strongly_regulated_dauer_genes |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00028789:PA14_vs_gacA_upregulated_4hr |
| | | WBPaper00028789:PA14_vs_OP50_upregulated_4hr |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035479:daf-16(RNAi)_downregulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00038231:Cry5B_2-fold_upregulated |
| | | WBPaper00038304:octr-1_regulated |
| | | WBPaper00039866:ClassComp_daf-19_upregulated |
| | | WBPaper00039866:SAM_daf-19_upregulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041960:daf-16_fasting_upregulated |
| | | WBPaper00041960:jun-1_fasting_upregulated |
| | | WBPaper00041960:kgb-1_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated |
| | | WBPaper00041960:N2_fasting_upregulated_9hto12h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00042274:tbx-2(bx59)_upregulated |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00044013:nasp-1_downregulated |
| | | WBPaper00044091:Bpseudomallei_induced_4h |
| | | WBPaper00045015:nhr-25(RNAi)_upregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00047021:MWCNT_downregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00051448:P.aeruginosa_Slow-Killing_upregulated |
| | | WBPaper00053550:daf-19(m86)_upregulated_3-fold-embryo |
| | | WBPaper00053550:daf-19(m86)_upregulated_L1 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_12 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(66_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction | WBInteraction000038624 |
| | | WBInteraction000351902 |
| | | WBInteraction000354409 |
| | | WBInteraction000565556 |
| | | WBInteraction000578690 |
| | | WBInteraction000580458 |
| | | WBInteraction000583627 |
| | | WBInteraction000584010 |
| Map_info | Map | X | Position | -0.047642 | Error | 0.01533 |
| | Positive | Positive_clone | F08F1 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4919 |
| | Pseudo_map_position |
| Reference | WBPaper00023907 |
| | WBPaper00038491 |
| | WBPaper00055090 |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
