Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006600

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006600SMapS_parentSequenceZK1290
IdentityVersion1
NameCGC_nametph-1Person_evidenceWBPerson545
Sequence_nameZK1290.2
Molecular_nameZK1290.2a
ZK1290.2a.1
CE39457
ZK1290.2b
CE39458
ZK1290.2b.1
Other_nameCELE_ZK1290.2Accession_evidenceNDBBX284602
Public_nametph-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classtph
Allele (36)
Strain (17)
RNASeq_FPKM (74)
GO_annotation (39)
Ortholog (39)
ParalogWBGene00000240Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000296Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
Structured_descriptionConcise_descriptiontph-1 encodes tryptophan hydroxylase, the enzyme that catalyzes the rate-limiting first step in serotonin biosynthesis; in vivo, tph-1 activity is required for serotonin biosynthesis, and well-fed animals mutant for tph-1 exhibit changes in behavioral and metabolic processes similar to those caused by starvation: slower rates of egg laying and pharyngeal pumping, dauer larval arrest, increased fat storage, and an extended reproductive lifespan; genetic studies indicate that, in regulating feeding and metabolism, tph-1 interacts with the daf-7/TGF-beta and daf-2/insulin-like signaling pathways; a TPH-1::GFP reporter is expressed in the serotonergic neurons: NSM, ADF, HSN (hermaphrodite-specific), CP (male-specific), and also rarely in the AIM and RIH neurons.Paper_evidenceWBPaper00003903
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated29 Nov 2005 00:00:00
Automated_descriptionPredicted to enable tryptophan 5-monooxygenase activity. Involved in several processes, including determination of adult lifespan; locomotory exploration behavior; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol and neuron projection. Expressed in CP neuron; nerve ring; and pharynx. Used to study alcohol use disorder and cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol use disorder; attention deficit hyperactivity disorder; and autistic disorder. Is an ortholog of human TPH1 (tryptophan hydroxylase 1) and TPH2 (tryptophan hydroxylase 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:809Homo sapiensPaper_evidenceWBPaper00034643
Curator_confirmedWBPerson324
Date_last_updated28 May 2019 00:00:00
DOID:1574Homo sapiensPaper_evidenceWBPaper00034740
Curator_confirmedWBPerson324
Date_last_updated17 Jun 2019 00:00:00
Potential_model (12)
Models_disease_assertedWBDOannot00000681
WBDOannot00000714
Molecular_infoCorresponding_CDSZK1290.2a
ZK1290.2b
Corresponding_CDS_historyZK1290.2a:wp151
ZK1290.2b:wp151
Corresponding_transcriptZK1290.2a.1
ZK1290.2b.1
Other_sequenceGRC01852_1
BXC05583_1
ES739311.1
EY473361.1
HBC24515_1
GR12810
Associated_featureWBsf019094
WBsf221610
Experimental_infoRNAi_resultWBRNAi00114357Inferred_automaticallyRNAi_primary
WBRNAi00027046Inferred_automaticallyRNAi_primary
WBRNAi00114348Inferred_automaticallyRNAi_primary
WBRNAi00027047Inferred_automaticallyRNAi_primary
WBRNAi00027556Inferred_automaticallyRNAi_primary
WBRNAi00027880Inferred_automaticallyRNAi_primary
WBRNAi00102730Inferred_automaticallyRNAi_primary
WBRNAi00059211Inferred_automaticallyRNAi_primary
WBRNAi00021865Inferred_automaticallyRNAi_primary
Expr_pattern (20)
Drives_construct (60)
Construct_productWBCnstr00006436
WBCnstr00006466
WBCnstr00009598
WBCnstr00018069
WBCnstr00022691
WBCnstr00022692
WBCnstr00022700
WBCnstr00034278
WBCnstr00038791
Regulate_expr_clusterWBPaper00059224:tph-1(mg280)_downregulated
WBPaper00059224:tph-1(mg280)_upregulated
WBPaper00060921:tph-1(mg280)_downregulated
WBPaper00060921:tph-1(mg280)_upregulated
AntibodyWBAntibody00000253
Microarray_results (28)
Expression_cluster (68)
InteractionWBInteraction000001000
WBInteraction000001001
WBInteraction000001002
WBInteraction000001155
WBInteraction000001156
WBInteraction000001157
WBInteraction000001158
WBInteraction000001159
WBInteraction000001573
WBInteraction000002262
WBInteraction000002288
WBInteraction000002545
WBInteraction000002554
WBInteraction000002813
WBInteraction000003290
WBInteraction000003891
WBInteraction000003892
WBInteraction000003893
WBInteraction000003894
WBInteraction000003923
WBInteraction000003996
WBInteraction000004935
WBInteraction000005376
WBInteraction000005377
WBInteraction000005378
WBInteraction000005705
WBInteraction000005784
WBInteraction000005785
WBInteraction000005826
WBInteraction000005827
WBInteraction000005848
WBInteraction000008878
WBInteraction000009059
WBInteraction000009061
WBInteraction000009062
WBInteraction000009063
WBInteraction000009064
WBInteraction000009066
WBInteraction000009575
WBInteraction000009914
WBInteraction000009916
WBInteraction000028274
WBInteraction000028283
WBInteraction000028576
WBInteraction000029333
WBInteraction000029600
WBInteraction000029608
WBInteraction000029651
WBInteraction000029652
WBInteraction000030241
WBInteraction000030258
WBInteraction000030453
WBInteraction000031854
WBInteraction000052679
WBInteraction000052944
WBInteraction000147212
WBInteraction000150116
WBInteraction000150821
WBInteraction000161325
WBInteraction000165595
WBInteraction000165624
WBInteraction000165719
WBInteraction000165769
WBInteraction000165839
WBInteraction000165906
WBInteraction000166159
WBInteraction000166351
WBInteraction000166372
WBInteraction000166373
WBInteraction000166402
WBInteraction000166414
WBInteraction000166430
WBInteraction000301442
WBInteraction000316807
WBInteraction000360182
WBInteraction000500144
WBInteraction000500515
WBInteraction000501477
WBInteraction000501478
WBInteraction000501479
WBInteraction000501480
WBInteraction000501786
WBInteraction000501902
WBInteraction000501949
WBInteraction000502219
WBInteraction000502261
WBInteraction000502430
WBInteraction000502431
WBInteraction000502728
WBInteraction000502779
WBInteraction000502780
WBInteraction000503445
WBInteraction000503446
WBInteraction000503623
WBInteraction000503652
WBInteraction000503653
WBInteraction000503654
WBInteraction000503686
WBInteraction000503953
WBInteraction000503954
WBInteraction000504061
WBInteraction000504062
WBInteraction000504063
WBInteraction000504372
WBInteraction000504373
WBInteraction000504606
WBInteraction000505136
WBInteraction000505137
WBInteraction000519590
WBInteraction000519829
WBInteraction000519830
WBInteraction000520713
WBInteraction000520715
WBInteraction000520716
WBInteraction000520738
WBInteraction000520958
WBInteraction000525337
WBInteraction000534841
WBInteraction000537565
WBInteraction000537566
WBInteraction000541577
WBInteraction000541767
WBInteraction000541888
WBInteraction000542449
WBInteraction000542450
WBInteraction000542451
WBInteraction000569793
WBInteraction000569799
WBProcessWBbiopr:00000001
Map_infoMapIIPosition0.504594Error5.8e-05
PositivePositive_cloneZK1290Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4715
4733
Pseudo_map_position
Reference (270)
RemarkSequence connection from [Sze JY, Ruvkun G]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene