WormBase Tree Display for Gene: WBGene00006600
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| WBGene00006600 | SMap | S_parent | Sequence | ZK1290 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tph-1 | Person_evidence | WBPerson545 | |||||
| Sequence_name | ZK1290.2 | ||||||||
| Molecular_name | ZK1290.2a | ||||||||
| ZK1290.2a.1 | |||||||||
| CE39457 | |||||||||
| ZK1290.2b | |||||||||
| CE39458 | |||||||||
| ZK1290.2b.1 | |||||||||
| Other_name | CELE_ZK1290.2 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | tph-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tph | ||||||||
| Allele (36) | |||||||||
| Strain (17) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (39) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00000240 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000296 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | tph-1 encodes tryptophan hydroxylase, the enzyme that catalyzes the rate-limiting first step in serotonin biosynthesis; in vivo, tph-1 activity is required for serotonin biosynthesis, and well-fed animals mutant for tph-1 exhibit changes in behavioral and metabolic processes similar to those caused by starvation: slower rates of egg laying and pharyngeal pumping, dauer larval arrest, increased fat storage, and an extended reproductive lifespan; genetic studies indicate that, in regulating feeding and metabolism, tph-1 interacts with the daf-7/TGF-beta and daf-2/insulin-like signaling pathways; a TPH-1::GFP reporter is expressed in the serotonergic neurons: NSM, ADF, HSN (hermaphrodite-specific), CP (male-specific), and also rarely in the AIM and RIH neurons. | Paper_evidence | WBPaper00003903 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 29 Nov 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable tryptophan 5-monooxygenase activity. Involved in several processes, including determination of adult lifespan; locomotory exploration behavior; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol and neuron projection. Expressed in CP neuron; nerve ring; and pharynx. Used to study alcohol use disorder and cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol use disorder; attention deficit hyperactivity disorder; and autistic disorder. Is an ortholog of human TPH1 (tryptophan hydroxylase 1) and TPH2 (tryptophan hydroxylase 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:809 | Homo sapiens | Paper_evidence | WBPaper00034643 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 May 2019 00:00:00 | ||||||||
| DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00034740 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Jun 2019 00:00:00 | ||||||||
| Potential_model (12) | |||||||||
| Models_disease_asserted | WBDOannot00000681 | ||||||||
| WBDOannot00000714 | |||||||||
| Molecular_info | Corresponding_CDS | ZK1290.2a | |||||||
| ZK1290.2b | |||||||||
| Corresponding_CDS_history | ZK1290.2a:wp151 | ||||||||
| ZK1290.2b:wp151 | |||||||||
| Corresponding_transcript | ZK1290.2a.1 | ||||||||
| ZK1290.2b.1 | |||||||||
| Other_sequence | GRC01852_1 | ||||||||
| BXC05583_1 | |||||||||
| ES739311.1 | |||||||||
| EY473361.1 | |||||||||
| HBC24515_1 | |||||||||
| GR12810 | |||||||||
| Associated_feature | WBsf019094 | ||||||||
| WBsf221610 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00114357 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027046 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114348 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027047 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027556 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027880 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00102730 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00059211 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021865 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (20) | |||||||||
| Drives_construct (60) | |||||||||
| Construct_product | WBCnstr00006436 | ||||||||
| WBCnstr00006466 | |||||||||
| WBCnstr00009598 | |||||||||
| WBCnstr00018069 | |||||||||
| WBCnstr00022691 | |||||||||
| WBCnstr00022692 | |||||||||
| WBCnstr00022700 | |||||||||
| WBCnstr00034278 | |||||||||
| WBCnstr00038791 | |||||||||
| Regulate_expr_cluster | WBPaper00059224:tph-1(mg280)_downregulated | ||||||||
| WBPaper00059224:tph-1(mg280)_upregulated | |||||||||
| WBPaper00060921:tph-1(mg280)_downregulated | |||||||||
| WBPaper00060921:tph-1(mg280)_upregulated | |||||||||
| Antibody | WBAntibody00000253 | ||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (68) | |||||||||
| Interaction (128) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | II | Position | 0.504594 | Error | 5.8e-05 | |||
| Positive | Positive_clone | ZK1290 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4715 | |||||||
| 4733 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (270) | |||||||||
| Remark | Sequence connection from [Sze JY, Ruvkun G] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
