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WormBase Tree Display for Gene: WBGene00006600

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Name Class

WBGene00006600SMapS_parentSequenceZK1290
IdentityVersion1
NameCGC_nametph-1Person_evidenceWBPerson545
Sequence_nameZK1290.2
Molecular_nameZK1290.2a
ZK1290.2a.1
CE39457
ZK1290.2b
CE39458
ZK1290.2b.1
Other_nameCELE_ZK1290.2Accession_evidenceNDBBX284602
Public_nametph-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classtph
Allele (36)
Strain (17)
RNASeq_FPKM (74)
GO_annotation (39)
OrthologWBGene00054384Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00033840Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00163736Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00123438Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00227917Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g12622Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g12325Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g6867Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g12245Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g9214Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g27485Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g16833Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g647Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g4828Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g17151Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00368.g9851Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-tph-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g15036Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00169.g6167Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_09395Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_006546Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g12514Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g1688Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_20252200Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrII_pilon.g5048Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00247259Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00283745Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00267715Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00291553Trichuris murisFrom_analysisWormBase-Compara
FB:FBgn0035187Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-030317-1Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-040624-4Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-030805-6Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
HGNC:12008Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
HGNC:20692Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
MGI:98796Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
MGI:2651811Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
RGD:3895Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
RGD:631332Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
OMA
OrthoFinder
Panther
PhylomeDB
ParalogWBGene00000240Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00000296Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
Structured_descriptionConcise_descriptiontph-1 encodes tryptophan hydroxylase, the enzyme that catalyzes the rate-limiting first step in serotonin biosynthesis; in vivo, tph-1 activity is required for serotonin biosynthesis, and well-fed animals mutant for tph-1 exhibit changes in behavioral and metabolic processes similar to those caused by starvation: slower rates of egg laying and pharyngeal pumping, dauer larval arrest, increased fat storage, and an extended reproductive lifespan; genetic studies indicate that, in regulating feeding and metabolism, tph-1 interacts with the daf-7/TGF-beta and daf-2/insulin-like signaling pathways; a TPH-1::GFP reporter is expressed in the serotonergic neurons: NSM, ADF, HSN (hermaphrodite-specific), CP (male-specific), and also rarely in the AIM and RIH neurons.Paper_evidenceWBPaper00003903
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated29 Nov 2005 00:00:00
Automated_descriptionPredicted to enable tryptophan 5-monooxygenase activity. Involved in several processes, including determination of adult lifespan; locomotory exploration behavior; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol and neuron projection. Expressed in CP neuron; nerve ring; and pharynx. Used to study alcohol use disorder and cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol use disorder; attention deficit hyperactivity disorder; and autistic disorder. Is an ortholog of human TPH1 (tryptophan hydroxylase 1) and TPH2 (tryptophan hydroxylase 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:809Homo sapiensPaper_evidenceWBPaper00034643
Curator_confirmedWBPerson324
Date_last_updated28 May 2019 00:00:00
DOID:1574Homo sapiensPaper_evidenceWBPaper00034740
Curator_confirmedWBPerson324
Date_last_updated17 Jun 2019 00:00:00
Potential_model (12)
Models_disease_assertedWBDOannot00000681
WBDOannot00000714
Molecular_infoCorresponding_CDSZK1290.2a
ZK1290.2b
Corresponding_CDS_historyZK1290.2a:wp151
ZK1290.2b:wp151
Corresponding_transcriptZK1290.2a.1
ZK1290.2b.1
Other_sequenceGRC01852_1
BXC05583_1
ES739311.1
EY473361.1
HBC24515_1
GR12810
Associated_featureWBsf019094
WBsf221610
Experimental_infoRNAi_resultWBRNAi00114357Inferred_automaticallyRNAi_primary
WBRNAi00027046Inferred_automaticallyRNAi_primary
WBRNAi00114348Inferred_automaticallyRNAi_primary
WBRNAi00027047Inferred_automaticallyRNAi_primary
WBRNAi00027556Inferred_automaticallyRNAi_primary
WBRNAi00027880Inferred_automaticallyRNAi_primary
WBRNAi00102730Inferred_automaticallyRNAi_primary
WBRNAi00059211Inferred_automaticallyRNAi_primary
WBRNAi00021865Inferred_automaticallyRNAi_primary
Expr_pattern (20)
Drives_construct (60)
Construct_productWBCnstr00006436
WBCnstr00006466
WBCnstr00009598
WBCnstr00018069
WBCnstr00022691
WBCnstr00022692
WBCnstr00022700
WBCnstr00034278
WBCnstr00038791
Regulate_expr_clusterWBPaper00059224:tph-1(mg280)_downregulated
WBPaper00059224:tph-1(mg280)_upregulated
WBPaper00060921:tph-1(mg280)_downregulated
WBPaper00060921:tph-1(mg280)_upregulated
AntibodyWBAntibody00000253
Microarray_results (28)
Expression_cluster (68)
Interaction (128)
WBProcessWBbiopr:00000001
Map_infoMapIIPosition0.504594Error5.8e-05
PositivePositive_cloneZK1290Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4715
4733
Pseudo_map_position
Reference (270)
RemarkSequence connection from [Sze JY, Ruvkun G]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene