WormBase Tree Display for Gene: WBGene00006598
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| WBGene00006598 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y37A1B | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | tor-2 | Person_evidence | WBPerson87 | |||||
| Sequence_name | Y37A1B.13 | ||||||||
| Molecular_name | Y37A1B.13 | ||||||||
| Y37A1B.13.1 | |||||||||
| CE49834 | |||||||||
| Other_name | dyt-1 | ||||||||
| CELE_Y37A1B.13 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | tor-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tor | ||||||||
| Allele (37) | |||||||||
| Strain | WBStrain00035171 | ||||||||
| WBStrain00035173 | |||||||||
| WBStrain00035174 | |||||||||
| WBStrain00035175 | |||||||||
| WBStrain00035176 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP4572 | ||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00003870 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00006597 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | tor-2 encodes a AAA ATPase that, along with TOR-1 and OOC-5, comprise the three C. elegans orthologs of human torsinA; overexpression of TOR-2 in nematodes with polyglutamine repeat-induced protein aggregates indicates that TOR-2 can suppress protein aggregation, suggesting TOR-2 may play a role in regulation of protein folding; in wild-type animals, TOR-2 localizes to the endoplasmic reticulum; in animals containing polyglutamine protein aggregates, TOR-2 localizes to these sites of protein aggregation. | Paper_evidence | WBPaper00005722 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 10 Jan 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in cellular response to misfolded protein; negative regulation of gene expression; and regulation of neuron apoptotic process. Located in endoplasmic reticulum. Expressed in neurons. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-5 and torsion dystonia 1. Is an ortholog of human TOR1A (torsin family 1 member A) and TOR1B (torsin family 1 member B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00025083 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 08 Aug 2013 00:00:00 | ||||||||
| Potential_model | DOID:0080981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3098) | |||||
| DOID:0060730 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3098) | ||||||
| Modifies_disease | DOID:543 | ||||||||
| Models_disease_in_annotation | WBDOannot00000223 | ||||||||
| Modifies_disease_in_annotation | WBDOannot00000217 | ||||||||
| Molecular_info | Corresponding_CDS | Y37A1B.13 | |||||||
| Corresponding_CDS_history | Y37A1B.13:wp243 | ||||||||
| Corresponding_transcript | Y37A1B.13.1 | ||||||||
| Associated_feature | WBsf667651 | ||||||||
| WBsf231180 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00076763 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00055849 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020200 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00080637 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036777 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2700 | ||||||||
| Expr3237 | |||||||||
| Expr1159380 | |||||||||
| Expr2017461 | |||||||||
| Expr2035600 | |||||||||
| Drives_construct | WBCnstr00000125 | ||||||||
| WBCnstr00000126 | |||||||||
| WBCnstr00000127 | |||||||||
| WBCnstr00000128 | |||||||||
| WBCnstr00006215 | |||||||||
| WBCnstr00011243 | |||||||||
| WBCnstr00034280 | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000603 | ||||||||
| WBAntibody00000688 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (79) | |||||||||
| Interaction (37) | |||||||||
| WBProcess | WBbiopr:00000078 | ||||||||
| Map_info | Map | IV | Position | 11.0084 | Error | 0.008317 | |||
| Positive | Positive_clone | Y37A1B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Sequence connection from [Caldwell GA] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
