WormBase Tree Display for Gene: WBGene00003870
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| WBGene00003870 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | ooc-5 | Person_evidence | WBPerson252 | |||||
| Sequence_name | C18E9.11 | ||||||||
| Molecular_name | C18E9.11a | ||||||||
| C18E9.11a.1 | |||||||||
| CE28283 | |||||||||
| C18E9.11b | |||||||||
| CE28284 | |||||||||
| C18E9.11b.1 | |||||||||
| Other_name | CELE_C18E9.11 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | ooc-5 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (12) | |||||||||
| Disease_info | Experimental_model | DOID:0060730 | Homo sapiens | Paper_evidence | WBPaper00005005 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 14 Mar 2023 00:00:00 | ||||||||
| Potential_model | DOID:0080981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3098) | |||||
| DOID:0060730 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3098) | ||||||
| Disease_relevance | Mutations in human Torsin1A (orthologous to elegans, tor-2, tor-1 and ooc-5) are associated with Torsion Dystonia, a movement disorder characterized by involuntary muscle contractions and twisting postures; C. elegans has been used to study Torsin protein function in models of polygutamine (polyQ) aggregation and Parkinson''s disease, these models showed that tor-2 had a protective effect against PolyQ aggregation, as well as protected dopaminergic neurons against chemical or alpha-synuclein -induced degeneration; ooc-5 was not as effective in reducing polyQ aggregates when functioning alone, as compared to functioning together with tor-2, indicating a cumulative effect of torsin protein activity in suppressing misfolded protein formation. | Homo sapiens | Paper_evidence | WBPaper00006152 | |||||
| WBPaper00025083 | |||||||||
| WBPaper00005722 | |||||||||
| Accession_evidence | OMIM | 128100 | |||||||
| 168600 | |||||||||
| 605204 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 Jul 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000219 | ||||||||
| Molecular_info | Corresponding_CDS | C18E9.11a | |||||||
| C18E9.11b | |||||||||
| Corresponding_transcript | C18E9.11a.1 | ||||||||
| C18E9.11b.1 | |||||||||
| Other_sequence | HG02251 | ||||||||
| Acan_isotig09585 | |||||||||
| Dviv_isotig23880 | |||||||||
| Oden_isotig14624 | |||||||||
| HGC02317_1 | |||||||||
| CBC04366_1 | |||||||||
| JI175562.1 | |||||||||
| Oden_isotig14625 | |||||||||
| Associated_feature | WBsf644523 | ||||||||
| WBsf658041 | |||||||||
| WBsf717021 | |||||||||
| WBsf221841 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00092582 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00040950 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00080636 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040949 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1735 | ||||||||
| Expr11290 | |||||||||
| Expr1022484 | |||||||||
| Expr1031823 | |||||||||
| Expr1144993 | |||||||||
| Expr2014629 | |||||||||
| Expr2032862 | |||||||||
| Drives_construct | WBCnstr00018740 | ||||||||
| WBCnstr00035818 | |||||||||
| Construct_product | WBCnstr00035818 | ||||||||
| Antibody | WBAntibody00000435 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (84) | |||||||||
| Interaction (43) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| WBbiopr:00000078 | |||||||||
| Map_info | Map | II | Position | 0.950582 | Error | 0.004541 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C18E9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3604 | |||||||
| 3605 | |||||||||
| 4472 | |||||||||
| 5506 | |||||||||
| Reference (28) | |||||||||
| Remark | Sequence from L.S.Rose. | ||||||||
| Method | Gene |
