WormBase Tree Display for Gene: WBGene00006593

WBGene00006593 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: tol-1 Person_evidence: WBPerson1122
      Sequence_name: C07F11.1
      Molecular_name: C07F11.1
        C07F11.1.1
        CE28818
      Other_name: C07F11.a Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        C07F11.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_C07F11.1 Accession_evidence: NDB BX284601
      Public_name: tol-1
    DB_info: Database: AceView gene 1A933
        WormQTL gene WBGene00006593
        WormFlux gene WBGene00006593
        NDB locus_tag CELE_C07F11.1
        Panther gene CAEEL|WormBase=WBGene00006593|UniProtKB=Q9N5Z3
          family PTHR24373
        NCBI gene 171635
        RefSeq protein NM_001025812.6
        TREEFAM TREEFAM_ID TF325595
        TrEMBL UniProtAcc Q9N5Z3
        UniProt_GCRP UniProtAcc Q9N5Z3
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tol
    Allele (303)
    Strain: WBStrain00007217
      WBStrain00021957
      WBStrain00021972
      WBStrain00029108
    RNASeq_FPKM (74)
    GO_annotation: 00095698
      00095699
      00095700
      00095701
      00095702
      00095703
      00095704
      00095705
      00105846
      00114408
    Contained_in_operon: CEOP1008
    Ortholog (48)
    Paralog: WBGene00003915 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008977 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00011971 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020649 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022789 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: tol-1 encodes a predicted transmembrane protein that is the sole C. elegans Toll-like receptor (TLR); TOL-1 is required for proper embryonic development and for pathogen avoidance behavior, and is expressed primarily in the nervous system. Paper_evidence: WBPaper00004692
          Curator_confirmed: WBPerson1843
          Date_last_updated: 28 Feb 2006 00:00:00
      Automated_description: Predicted to enable signaling receptor activity. Involved in defense response to Gram-negative bacterium and embryo development. Predicted to be located in extracellular matrix and extracellular space. Expressed in neurons. Is an ortholog of several human genes including CHAD (chondroadherin); ELFN2 (extracellular leucine rich repeat and fibronectin type III domain containing 2); and TRIL (TLR4 interactor with leucine rich repeats). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C07F11.1
    Corresponding_CDS_history: C07F11.1b:wp115
    Corresponding_transcript: C07F11.1.1
    Other_sequence (20)
    Associated_feature (24)
  Experimental_info: RNAi_result: WBRNAi00112556 Inferred_automatically: RNAi_primary
      WBRNAi00063081 Inferred_automatically: RNAi_primary
      WBRNAi00082217 Inferred_automatically: RNAi_primary
      WBRNAi00004994 Inferred_automatically: RNAi_primary
      WBRNAi00040008 Inferred_automatically: RNAi_primary
      WBRNAi00028638 Inferred_automatically: RNAi_primary
      WBRNAi00116880 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1361
      Expr12434
      Expr15432
      Expr1027970
      Expr1032726
      Expr1144085
      Expr2017451
      Expr2035590
    Drives_construct: WBCnstr00010235
      WBCnstr00021084
    Construct_product: WBCnstr00010235
      WBCnstr00042643
      WBCnstr00042645
    Microarray_results (19)
    Expression_cluster (133)
    Interaction (23)
    WBProcess: WBbiopr:00000008
      WBbiopr:00000039
  Map_info: Map: I Position: -19.0389 Error: 0.00579
    Positive: Positive_clone: C07F11 Inferred_automatically: From sequence, transcript, pseudogene data
        W05D2
    Mapping_data: Multi_point: 4391
        4732
        4872
    Pseudo_map_position
  Reference (45)
  Remark: Sequence connection from [Pujol N, Ewbank JJ] based on AF348166
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene