WormBase Tree Display for Gene: WBGene00006543
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| WBGene00006543 | SMap | S_parent | Sequence | F21H11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | tbx-2 | Person_evidence | WBPerson107 | |||||
| Sequence_name | F21H11.3 | ||||||||
| Molecular_name | F21H11.3 | ||||||||
| F21H11.3.1 | |||||||||
| CE01245 | |||||||||
| Other_name | sdf-13 | ||||||||
| mab-22 | Person_evidence | WBPerson261 | |||||||
| CELE_F21H11.3 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | tbx-2 | ||||||||
| DB_info | Database | AceView | gene | 3G222 | |||||
| WormQTL | gene | WBGene00006543 | |||||||
| WormFlux | gene | WBGene00006543 | |||||||
| NDB | locus_tag | CELE_F21H11.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006543|UniProtKB=Q19691 | |||||||
| family | PTHR11267 | ||||||||
| NCBI | gene | 175698 | |||||||
| RefSeq | protein | NM_001382860.2 | |||||||
| SwissProt | UniProtAcc | Q19691 | |||||||
| UniProt_GCRP | UniProtAcc | Q19691 | |||||||
| OMIM | gene | 600747 | |||||||
| 601621 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 31 Jul 2013 13:40:41 | WBPerson2970 | Event | Acquires_merge | WBGene00003113 | ||||
| Name_change | Other_name | mab-22 | |||||||
| Acquires_merge | WBGene00003113 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tbx | ||||||||
| Allele (60) | |||||||||
| Legacy_information | [C.elegansII] NMK. Similarity to mouse Tbx genes, closest to mouse Tbx2 (70% identity in T box domain). (F21H11.3)[Agulnik et al. 1995] | ||||||||
| [C.elegansII] bx59ts : extensive loss of rays at 25C, not 15C. Divisions appear normal, possible ray assembly defect. NA1. [EM] | |||||||||
| Strain | WBStrain00003711 | ||||||||
| WBStrain00022191 | |||||||||
| WBStrain00022192 | |||||||||
| WBStrain00035675 | |||||||||
| WBStrain00007174 | |||||||||
| WBStrain00049269 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Ortholog (42) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | tbx-2 encodes one of 21 C. elegans T-box transcription factors; during development, tbx-2 activity is required for normal adaptation, but not chemotaxis, to attractive odorants sensed by the AWC amphid neurons; tbx-2 is required redundantly with unc-3 and unc-31 for negative regulation of dauer formation, and large-scale RNAi screens reveal an essential role for tbx-2 in early larval development, normal rates of postembryonic growth, and locomotory behavior; tbx-2 is also required along with pha-4 for embryonic precursor cells to adopt a pharyngeal muscle fate; TBX-2 and PHA-4 are mutually dependant on each other to maintain expression implicating them in a regulatory loop that controls commitment to the pharyngeal muscle fate; yeast two-hybrid assays have identified that TBX-2 interacts with UBC-9 (E2 SUMO conjugating enzyme) and GEI-17 (E3 SUMO ligase); based on the two-hybrid interaction and the similar pharyngeal muscle phenotype of ubc-9, it is likely that protein sumoylation is required for precursor-cell derived pharyngeal muscle development; antibodies to TBX-2 detect expression in the cytoplasm of amphid and pharyngeal neurons in larvae and adults, suggesting that TBX-2 function may be controlled, in part, by regulation of its subcellular localization; in addition, in situ hybridization studies indicate that tbx-2 mRNA is expressed during mid-embryogenesis; tbx-2 expression in the AWC amphid neurons is sufficient to rescue the olfactory adaptation defects seen in tbx-2 mutant animals. | Paper_evidence | WBPaper00002132 | |||||
| WBPaper00002863 | |||||||||
| WBPaper00004103 | |||||||||
| WBPaper00005423 | |||||||||
| WBPaper00006381 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00027631 | |||||||||
| WBPaper00028546 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 Mar 2007 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription repressor activity; core promoter sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including muscle structure development; neuron migration; and olfactory behavior. Located in cytoplasm and nucleus. Expressed in amphid neurons; body wall musculature; head neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); ulnar-mammary syndrome; and vertebral anomalies and variable endocrine and T-cell dysfunction. Is an ortholog of human TBX2 (T-box transcription factor 2) and TBX3 (T-box transcription factor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||
| DOID:0060614 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||||
| DOID:1882 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) | ||||||
| DOID:1681 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||||
| DOID:0070345 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||||
| Molecular_info | Corresponding_CDS | F21H11.3 | |||||||
| Corresponding_transcript | F21H11.3.1 | ||||||||
| Other_sequence (16) | |||||||||
| Associated_feature (13) | |||||||||
| Gene_product_binds | WBsf977981 | ||||||||
| WBsf977982 | |||||||||
| WBsf977983 | |||||||||
| Transcription_factor | WBTranscriptionFactor000208 | ||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00011882 | ||||||||
| WBCnstr00011883 | |||||||||
| WBCnstr00034310 | |||||||||
| Regulate_expr_cluster | WBPaper00042274:tbx-2(bx59)_downregulated | ||||||||
| WBPaper00042274:tbx-2(bx59)_upregulated | |||||||||
| Antibody | WBAntibody00000713 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (199) | |||||||||
| Interaction (62) | |||||||||
| Anatomy_function | WBbtf0263 | ||||||||
| WBbtf0264 | |||||||||
| Map_info | Map | III | Position | -2.08974 | Error | 0.015753 | |||
| Positive | Positive_clone | F21H11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4725 | |||||||
| Pseudo_map_position | |||||||||
| Reference (58) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
