WormBase Tree Display for Gene: WBGene00006543
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WBGene00006543 | SMap | S_parent | Sequence | F21H11 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | tbx-2 | Person_evidence | WBPerson107 | |||
Sequence_name | F21H11.3 | ||||||
Molecular_name | F21H11.3 | ||||||
F21H11.3.1 | |||||||
CE01245 | |||||||
Other_name | sdf-13 | ||||||
mab-22 | Person_evidence | WBPerson261 | |||||
CELE_F21H11.3 | Accession_evidence | NDB | BX284603 | ||||
Public_name | tbx-2 | ||||||
DB_info | Database | AceView | gene | 3G222 | |||
WormQTL | gene | WBGene00006543 | |||||
WormFlux | gene | WBGene00006543 | |||||
NDB | locus_tag | CELE_F21H11.3 | |||||
Panther | gene | CAEEL|WormBase=WBGene00006543|UniProtKB=Q19691 | |||||
family | PTHR11267 | ||||||
NCBI | gene | 175698 | |||||
RefSeq | protein | NM_001382860.2 | |||||
SwissProt | UniProtAcc | Q19691 | |||||
UniProt_GCRP | UniProtAcc | Q19691 | |||||
OMIM | gene | 600747 | |||||
601621 | |||||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | tbx | ||||||
Allele (60) | |||||||
Legacy_information | [C.elegansII] NMK. Similarity to mouse Tbx genes, closest to mouse Tbx2 (70% identity in T box domain). (F21H11.3)[Agulnik et al. 1995] | ||||||
[C.elegansII] bx59ts : extensive loss of rays at 25C, not 15C. Divisions appear normal, possible ray assembly defect. NA1. [EM] | |||||||
Strain | WBStrain00003711 | ||||||
WBStrain00022191 | |||||||
WBStrain00022192 | |||||||
WBStrain00035675 | |||||||
WBStrain00007174 | |||||||
WBStrain00049269 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (35) | |||||||
Ortholog (42) | |||||||
Paralog (21) | |||||||
Structured_description | Concise_description | tbx-2 encodes one of 21 C. elegans T-box transcription factors; during development, tbx-2 activity is required for normal adaptation, but not chemotaxis, to attractive odorants sensed by the AWC amphid neurons; tbx-2 is required redundantly with unc-3 and unc-31 for negative regulation of dauer formation, and large-scale RNAi screens reveal an essential role for tbx-2 in early larval development, normal rates of postembryonic growth, and locomotory behavior; tbx-2 is also required along with pha-4 for embryonic precursor cells to adopt a pharyngeal muscle fate; TBX-2 and PHA-4 are mutually dependant on each other to maintain expression implicating them in a regulatory loop that controls commitment to the pharyngeal muscle fate; yeast two-hybrid assays have identified that TBX-2 interacts with UBC-9 (E2 SUMO conjugating enzyme) and GEI-17 (E3 SUMO ligase); based on the two-hybrid interaction and the similar pharyngeal muscle phenotype of ubc-9, it is likely that protein sumoylation is required for precursor-cell derived pharyngeal muscle development; antibodies to TBX-2 detect expression in the cytoplasm of amphid and pharyngeal neurons in larvae and adults, suggesting that TBX-2 function may be controlled, in part, by regulation of its subcellular localization; in addition, in situ hybridization studies indicate that tbx-2 mRNA is expressed during mid-embryogenesis; tbx-2 expression in the AWC amphid neurons is sufficient to rescue the olfactory adaptation defects seen in tbx-2 mutant animals. | Paper_evidence | WBPaper00002132 | |||
WBPaper00002863 | |||||||
WBPaper00004103 | |||||||
WBPaper00005423 | |||||||
WBPaper00006381 | |||||||
WBPaper00025054 | |||||||
WBPaper00027631 | |||||||
WBPaper00028546 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson324 | |||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 16 Mar 2007 00:00:00 | ||||||
Automated_description | Enables DNA-binding transcription repressor activity; core promoter sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including muscle structure development; neuron migration; and olfactory behavior. Located in cytoplasm and nucleus. Expressed in amphid neurons; body wall musculature; head neurons; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); ulnar-mammary syndrome; and vertebral anomalies and variable endocrine and T-cell dysfunction. Is an ortholog of human TBX2 (T-box transcription factor 2) and TBX3 (T-box transcription factor 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||
DOID:0060614 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||
DOID:1882 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) | ||||
DOID:1681 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) | ||||
DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||
DOID:0070345 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11597) | ||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11602) | ||||
Molecular_info | Corresponding_CDS | F21H11.3 | |||||
Corresponding_transcript | F21H11.3.1 | ||||||
Other_sequence (16) | |||||||
Associated_feature (13) | |||||||
Gene_product_binds | WBsf977981 | ||||||
WBsf977982 | |||||||
WBsf977983 | |||||||
Transcription_factor | WBTranscriptionFactor000208 | ||||||
Experimental_info | RNAi_result (16) | ||||||
Expr_pattern (16) | |||||||
Drives_construct (12) | |||||||
Construct_product | WBCnstr00011882 | ||||||
WBCnstr00011883 | |||||||
WBCnstr00034310 | |||||||
Regulate_expr_cluster | WBPaper00042274:tbx-2(bx59)_downregulated | ||||||
WBPaper00042274:tbx-2(bx59)_upregulated | |||||||
Antibody | WBAntibody00000713 | ||||||
Microarray_results (19) | |||||||
Expression_cluster (199) | |||||||
Interaction (62) | |||||||
Anatomy_function | WBbtf0263 | ||||||
WBbtf0264 | |||||||
Map_info | Map | III | Position | -2.08974 | Error | 0.015753 | |
Positive | Positive_clone | F21H11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4725 | |||||
Pseudo_map_position | |||||||
Reference (58) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |