WormBase Tree Display for Gene: WBGene00006525
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| WBGene00006525 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tax-2 | Person_evidence | WBPerson148 | |||||
| Sequence_name | F36F2.5 | ||||||||
| Molecular_name | F36F2.5 | ||||||||
| F36F2.5.1 | |||||||||
| CE17780 | |||||||||
| Other_name | nrf-7 | Person_evidence | WBPerson4146 | ||||||
| CELE_F36F2.5 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | tax-2 | ||||||||
| DB_info | Database | AceView | gene | 1J601 | |||||
| WormQTL | gene | WBGene00006525 | |||||||
| WormFlux | gene | WBGene00006525 | |||||||
| NDB | locus_tag | CELE_F36F2.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006525|UniProtKB=G5EEE2 | |||||||
| family | PTHR45638 | ||||||||
| NCBI | gene | 172723 | |||||||
| RefSeq | protein | NM_060026.6 | |||||||
| TrEMBL | UniProtAcc | G5EEE2 | |||||||
| UniProt_GCRP | UniProtAcc | G5EEE2 | |||||||
| OMIM | gene | 600724 | |||||||
| 605080 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tax | ||||||||
| Reference_allele | WBVar00095111 | ||||||||
| Allele (72) | |||||||||
| Possibly_affected_by | WBVar02157258 | ||||||||
| Legacy_information | See also p671, p691, p694 | ||||||||
| [C.elegansII] p671 : defects in chemotaxis (all attractants), athermotactic; Odr; dye-filling reveals some amphid and phasmid axon defects. OA5: p691, p694. ks10, etc. [Dusenbery 1976; CX; FK] | |||||||||
| [Coburn C] Predicted polypeptide of 800aa, cyclic nucleotide gated channel family. p691 is P426S, weaker allele p694 is deletion of first exon, other alleles missense. | |||||||||
| Strain (18) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (29) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00000487 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000562 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00000563 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006526 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022295 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00001171 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006830 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | tax-2 encodes a cyclic nucleotide-gated channel beta subunit orthologous to the human gene ROD PHOTORECEPTOR CNG-CHANNEL BETA SUBUNIT (CNGB1; OMIM:600724), which when mutated leads to disease; TAX-2 activity is required for chemosensation, thermosensation, regulation of dauer larval development, normal axon guidance for some sensory neurons, and regulation of axonal outgrowth and morphology in late larval stages; a tax-2::GFP promoter fusion is expressed in nine pairs of amphid sensory neurons and a TAX-2::GFP fusion protein localizes to developing axons and sensory cilia. | Paper_evidence | WBPaper00002584 | |||||
| WBPaper00003016 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 19 Jun 2008 00:00:00 | ||||||||
| Automated_description | Contributes to intracellular cGMP-activated cation channel activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; negative regulation of cGMP-mediated signaling; and positive regulation of macromolecule biosynthetic process. Part of cation channel complex. Expressed in ciliated neurons. Human ortholog(s) of this gene implicated in achromatopsia 3 and retinitis pigmentosa 45. Is an ortholog of human CNGB1 (cyclic nucleotide gated channel subunit beta 1) and CNGB3 (cyclic nucleotide gated channel subunit beta 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110008 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2153) | ||||
| DOID:13399 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2153) | ||||||
| DOID:10584 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2151) | ||||||
| DOID:0110402 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2151) | ||||||
| Molecular_info | Corresponding_CDS | F36F2.5 | |||||||
| Corresponding_transcript | F36F2.5.1 | ||||||||
| Other_sequence (20) | |||||||||
| Associated_feature | WBsf655790 | ||||||||
| WBsf984555 | |||||||||
| WBsf218241 | |||||||||
| WBsf218242 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00046497 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00027700 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00003618 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (14) | |||||||||
| Drives_construct (11) | |||||||||
| Construct_product | WBCnstr00010491 | ||||||||
| WBCnstr00010494 | |||||||||
| WBCnstr00013109 | |||||||||
| WBCnstr00017617 | |||||||||
| WBCnstr00018887 | |||||||||
| WBCnstr00018888 | |||||||||
| WBCnstr00018889 | |||||||||
| WBCnstr00018890 | |||||||||
| WBCnstr00018891 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (87) | |||||||||
| Interaction (105) | |||||||||
| Anatomy_function | WBbtf0123 | ||||||||
| WBbtf0124 | |||||||||
| WBbtf0431 | |||||||||
| WBProcess | WBbiopr:00000025 | ||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | I | Position | 3.40539 | Error | 0.013031 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F36F2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| T18D4 | |||||||||
| Mapping_data | Multi_point | 3681 | |||||||
| 4139 | |||||||||
| 4988 | |||||||||
| Reference (222) | |||||||||
| Remark | Extracted from Coburn & Bargmann (1996) | ||||||||
| Method | Gene |
