WormBase Tree Display for Gene: WBGene00006523

WBGene00006523 SMap: S_parent: Sequence: F26G5
  Identity: Version: 1
    Name: CGC_name: tam-1 Person_evidence: WBPerson959
      Sequence_name: F26G5.9
      Molecular_name: F26G5.9
        F26G5.9.1
        CE09704
      Other_name: CELE_F26G5.9 Accession_evidence: NDB BX284605
      Public_name: tam-1
    DB_info: Database: AceView gene 5F438
        WormQTL gene WBGene00006523
        WormFlux gene WBGene00006523
        NDB locus_tag CELE_F26G5.9
        Panther gene CAEEL|WormBase=WBGene00006523|UniProtKB=G5ED20
          family PTHR25462
        NCBI gene 178887
        RefSeq protein NM_071934.7
        TREEFAM TREEFAM_ID TF350293
        TrEMBL UniProtAcc G5ED20
        UniProt_GCRP UniProtAcc G5ED20
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tam
    Allele (125)
    Strain: WBStrain00030593
      WBStrain00030594
      WBStrain00030595
      WBStrain00036992
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (24)
    Paralog: WBGene00003598 Caenorhabditis elegans From_analysis: Panther
      WBGene00003599 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays; the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin; about 3% to 10% of tam-1 transcripts are RNA edited to change A to G resulting in a synonymous change to residue 784 from an L to a L. Paper_evidence: WBPaper00003822
            WBPaper00005068
            WBPaper00012788
            WBPaper00012830
            WBPaper00012882
            WBPaper00012897
            WBPaper00013003
            WBPaper00045975
          Curator_confirmed: WBPerson1843
            WBPerson567
            WBPerson4025
          Date_last_updated: 28 Dec 2012 00:00:00
      Automated_description: Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including chromosome segregation; negative regulation of vulval development; and transcription initiation-coupled chromatin remodeling. Located in germ cell nucleus. Expressed in several structures, including germ line. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F26G5.9
    Corresponding_transcript: F26G5.9.1
    Other_sequence: FK804436.1
      Hbac_isotig06648
      HBC11786_1
      EX014679.1
    Associated_feature (18)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr972
      Expr2884
      Expr3582
      Expr1027851
      Expr1032676
      Expr1149610
      Expr2017295
      Expr2035430
    Drives_construct: WBCnstr00034326
    Construct_product: WBCnstr00011506
      WBCnstr00034326
    Antibody: WBAntibody00000256
    Microarray_results (20)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_downregulated_cDNA_12h
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037946:EGL-5_interacting
      WBPaper00038061:aldicarb_downregulated
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00045774:clk-1_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046509:htz-1(ok3099)_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_upregulated
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050859:downregulated_glh-1(gk100)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059174:MEG-3_interacting
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:AMso_parent
      WBPaper00061340:ASE_parent
      WBPaper00061340:AVK
      WBPaper00061340:B
      WBPaper00061340:I1_parent
      WBPaper00061340:Neuroblast_AFD_RMD
      WBPaper00061340:Neuroblast_AWC_SAAVx
      WBPaper00061340:Parents_of_Y_DA6_DA7_DA9
      WBPaper00061340:RIV
      WBPaper00061340:SIB
      WBPaper00061527:C10G11.7_14641-attf-2_12369
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061651:XXX_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      cgc4386_cluster_6_2
      cgc4489_group_9
      WBPaper00025032:cluster_7
      WBPaper00025032:cluster_39
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00031060:2-deoxy-D-glucose_downregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00036286:Pattern_F
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00040963:TA300_down
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(83_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:Cluster_F
      [cgc6390]:mixed_oogenesis-somatic
    Interaction (106)
  Map_info: Map: V Position: -3.66231 Error: 0.003466
    Positive: Positive_clone: F26G5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4514
        4718
        5591
        5661
    Pseudo_map_position
  Reference (22)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene