WormBase Tree Display for Gene: WBGene00004995
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| WBGene00004995 | Evidence | Author_evidence | Patthy L | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Hodgkin JA | |||||||||
| SMap | S_parent | Sequence | C28C12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | spp-10 | |||||||
| Sequence_name | C28C12.7 | ||||||||
| Molecular_name | C28C12.7a | ||||||||
| C28C12.7a.1 | |||||||||
| CE29486 | |||||||||
| C28C12.7b | |||||||||
| CE31323 | |||||||||
| C28C12.7b.1 | |||||||||
| Other_name | CELE_C28C12.7 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | spp-10 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spp | ||||||||
| Allele (45) | |||||||||
| Strain | WBStrain00032093 | ||||||||
| WBStrain00036036 | |||||||||
| WBStrain00036070 | |||||||||
| WBStrain00036142 | |||||||||
| WBStrain00036210 | |||||||||
| WBStrain00036330 | |||||||||
| WBStrain00036673 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00113407 | ||||||||
| 00113408 | |||||||||
| 00113409 | |||||||||
| Ortholog (48) | |||||||||
| Paralog | WBGene00004992 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004993 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004998 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00005000 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. | Paper_evidence | WBPaper00013533 | |||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to be involved in sphingolipid metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including cystic fibrosis; lung disease (multiple); and sphingolipidosis (multiple). Is an ortholog of human PSAP (prosaposin) and PSAPL1 (prosaposin like 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (22) | ||||||||
| Molecular_info | Corresponding_CDS | C28C12.7a | |||||||
| C28C12.7b | |||||||||
| Corresponding_transcript | C28C12.7a.1 | ||||||||
| C28C12.7b.1 | |||||||||
| Other_sequence (32) | |||||||||
| Associated_feature | WBsf646166 | ||||||||
| WBsf718141 | |||||||||
| WBsf997226 | |||||||||
| WBsf228682 | |||||||||
| WBsf228683 | |||||||||
| WBsf228684 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00011295 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00041403 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011296 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075913 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041404 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00029297 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr5367 | ||||||||
| Expr1019104 | |||||||||
| Expr1032485 | |||||||||
| Expr1145434 | |||||||||
| Expr2016065 | |||||||||
| Expr2034301 | |||||||||
| Drives_construct | WBCnstr00003963 | ||||||||
| WBCnstr00035283 | |||||||||
| Construct_product | WBCnstr00035283 | ||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (185) | |||||||||
| Interaction (17) | |||||||||
| Map_info | Map | IV | Position | 3.83716 | Error | 0.002099 | |||
| Positive | Positive_clone | C28C12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5118 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00024209 | ||||||||
| WBPaper00025032 | |||||||||
| WBPaper00025088 | |||||||||
| WBPaper00025190 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00048489 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065937 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
