WormBase Tree Display for Gene: WBGene00004995
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WBGene00004995 | Evidence | Author_evidence | Patthy L | ||||
---|---|---|---|---|---|---|---|
Hodgkin JA | |||||||
SMap | S_parent | Sequence | C28C12 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | spp | ||||||
Allele (45) | |||||||
Strain | WBStrain00032093 | ||||||
WBStrain00036036 | |||||||
WBStrain00036070 | |||||||
WBStrain00036142 | |||||||
WBStrain00036210 | |||||||
WBStrain00036330 | |||||||
WBStrain00036673 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00113407 | ||||||
00113408 | |||||||
00113409 | |||||||
Ortholog (48) | |||||||
Paralog | WBGene00004992 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00004993 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004998 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00005000 | Caenorhabditis elegans | From_analysis | Panther | ||||
Structured_description | Concise_description | spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. | Paper_evidence | WBPaper00013533 | |||
Curator_confirmed | WBPerson1823 | ||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to be involved in sphingolipid metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including cystic fibrosis; lung disease (multiple); and sphingolipidosis (multiple). Is an ortholog of human PSAP (prosaposin) and PSAPL1 (prosaposin like 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (22) | ||||||
Molecular_info | Corresponding_CDS | C28C12.7a | |||||
C28C12.7b | |||||||
Corresponding_transcript | C28C12.7a.1 | ||||||
C28C12.7b.1 | |||||||
Other_sequence (32) | |||||||
Associated_feature | WBsf646166 | ||||||
WBsf718141 | |||||||
WBsf997226 | |||||||
WBsf228682 | |||||||
WBsf228683 | |||||||
WBsf228684 | |||||||
Experimental_info | RNAi_result | WBRNAi00011295 | Inferred_automatically | RNAi_primary | |||
WBRNAi00041403 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00011296 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00075913 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041404 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00029297 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr5367 | ||||||
Expr1019104 | |||||||
Expr1032485 | |||||||
Expr1145434 | |||||||
Expr2016065 | |||||||
Expr2034301 | |||||||
Drives_construct | WBCnstr00003963 | ||||||
WBCnstr00035283 | |||||||
Construct_product | WBCnstr00035283 | ||||||
Microarray_results (33) | |||||||
Expression_cluster (185) | |||||||
Interaction (17) | |||||||
Map_info | Map | IV | Position | 3.83716 | Error | 0.002099 | |
Positive | Positive_clone | C28C12 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 5118 | |||||
Pseudo_map_position | |||||||
Reference | WBPaper00024209 | ||||||
WBPaper00025032 | |||||||
WBPaper00025088 | |||||||
WBPaper00025190 | |||||||
WBPaper00038491 | |||||||
WBPaper00048489 | |||||||
WBPaper00055090 | |||||||
WBPaper00065937 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |