WormBase Tree Display for Gene: WBGene00004993
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| WBGene00004993 | Evidence | Author_evidence | Patthy L | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Hodgkin JA | |||||||||
| SMap | S_parent | Sequence | C28C12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | spp-8 | |||||||
| Sequence_name | C28C12.5 | ||||||||
| Molecular_name | C28C12.5 | ||||||||
| C28C12.5.1 | |||||||||
| CE04112 | |||||||||
| Other_name | CELE_C28C12.5 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | spp-8 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spp | ||||||||
| Allele (26) | |||||||||
| Possibly_affected_by | WBVar02153248 | ||||||||
| Strain | WBStrain00037700 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| Ortholog (33) | |||||||||
| Paralog | WBGene00004992 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00004998 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00005000 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00004995 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Automated_description | Enriched in OLL; PVD; hermaphrodite distal tip cell; intestine; and male distal tip cell based on SAGE; microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and skn-1 based on microarray and RNA-seq studies. Is affected by twenty-two chemicals including 1-methylnicotinamide; mianserin; and D-glucose based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Human PSAP enables several functions, including ganglioside binding activity; protein homodimerization activity; and scaffold protein binding activity. Is predicted to encode a protein with the following domains: Saposin B type, region 2; Saposin B type domain; Saposin-like type B, region 2; and Saposin-like. Is an ortholog of human PSAP (prosaposin). | Paper_evidence | WBPaper00065943 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110961 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9498) | ||||
| DOID:0060892 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9498) | ||||||
| DOID:0111330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:9498) | ||||||
| Molecular_info | Corresponding_CDS | C28C12.5 | |||||||
| Corresponding_transcript | C28C12.5.1 | ||||||||
| Other_sequence | CBC05108_1 | ||||||||
| CJC00917_1 | |||||||||
| CRC05139_1 | |||||||||
| CJC05336_1 | |||||||||
| CR01091 | |||||||||
| FD515225.1 | |||||||||
| CBC04916_1 | |||||||||
| CSC01755_1 | |||||||||
| Associated_feature | WBsf997227 | ||||||||
| WBsf997228 | |||||||||
| WBsf997229 | |||||||||
| WBsf1017851 | |||||||||
| WBsf228685 | |||||||||
| WBsf228686 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00011294 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00029296 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041402 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075912 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr15193 | ||||||||
| Expr1014155 | |||||||||
| Expr1032484 | |||||||||
| Expr1145433 | |||||||||
| Expr2016086 | |||||||||
| Expr2034322 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (253) | |||||||||
| Interaction (53) | |||||||||
| Map_info (3) | |||||||||
| Reference | WBPaper00024209 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00041771 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060006 | |||||||||
| WBPaper00065331 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
