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WormBase Tree Display for Gene: WBGene00004978

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Name Class

WBGene00004978SMapS_parentSequenceY47G6A
IdentityVersion3
NameCGC_namespg-7Person_evidenceWBPerson530
Sequence_nameY47G6A.10
Molecular_nameY47G6A.10
Y47G6A.10.1
CE34400
Other_namephi-23Person_evidenceWBPerson2582
let-517Person_evidenceWBPerson533
Y47G6A_247.gCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_Y47G6A.10Accession_evidenceNDBBX284601
Public_namespg-7
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:37WBPerson1971EventImportedInitial conversion from geneace
217 Mar 2005 13:54:35WBPerson2970Name_changeOther_namephi-23
305 Mar 2015 09:01:29WBPerson2970EventAcquires_mergeWBGene00002708
Name_changeOther_namelet-517
Acquires_mergeWBGene00002708
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classspg
Allele (228)
Legacy_information[C.elegansII] h264 : lethal. OA2: h757, h1398. [KR]
StrainWBStrain00023743
WBStrain00005598
RNASeq_FPKM (74)
GO_annotation (46)
Contained_in_operonCEOP1969
Ortholog (41)
ParalogWBGene00010842Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00015208Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021425Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00021615Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionspg-7 encodes a metalloprotease orthologous to human paraplegin, a nuclear-encoded mitochondrial metalloprotease mutations in which are associated with hereditary spastic paraplegia (spinal cord dysfunction); based upon studies of Saccharomyces cerevisiae SPG7, C. elegans SPG-7 is predicted to function as part of a mt-AAA metalloprotease that regulates proteolytic degradation of mitochondrial proteins and formation of multisubunit mitochondrial protein complexes; loss of spg-7 activity via large-scale RNAi indicates that SPG-7 function is required for embryonic and larval development, reproduction, normal body size and growth rates, and proper subcellular localization of an unc-54::POLYQ(Q35)-YFP transgene; in addition, postdevelopmental inactivation of spg-7 results in significantly increased adult lifespan.Paper_evidenceWBPaper00004402
WBPaper00004651
WBPaper00006395
WBPaper00006510
WBPaper00024269
WBPaper00024497
WBPaper00025054
WBPaper00029254
Curator_confirmedWBPerson1843
Date_last_updated11 Oct 2007 00:00:00
Automated_descriptionPredicted to enable metalloendopeptidase activity. Involved in several processes, including mitochondrial protein processing; positive regulation of nematode male tail tip morphogenesis; and regulation of gene expression. Predicted to be located in mitochondrion. Predicted to be part of m-AAA complex. Expressed in germ line. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia 5; and spinocerebellar ataxia type 28. Is an ortholog of human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050977Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:315)
DOID:0050952Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:315)
DOID:0050944Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:315)
DOID:0080840Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:315)
Molecular_infoCorresponding_CDSY47G6A.10
Corresponding_CDS_historyY47G6A.10:wp102
Corresponding_transcriptY47G6A.10.1
Other_sequence (66)
Associated_feature (11)
Experimental_infoRNAi_resultWBRNAi00117224Inferred_automaticallyRNAi_primary
WBRNAi00112542Inferred_automaticallyRNAi_primary
WBRNAi00093428Inferred_automaticallyRNAi_primary
WBRNAi00084588Inferred_automaticallyRNAi_primary
WBRNAi00110139Inferred_automaticallyRNAi_primary
WBRNAi00090770Inferred_automaticallyRNAi_primary
WBRNAi00026741Inferred_automaticallyRNAi_primary
WBRNAi00084620Inferred_automaticallyRNAi_primary
WBRNAi00093175Inferred_automaticallyRNAi_primary
WBRNAi00093696Inferred_automaticallyRNAi_primary
WBRNAi00110113Inferred_automaticallyRNAi_primary
WBRNAi00095791Inferred_automaticallyRNAi_primary
WBRNAi00084591Inferred_automaticallyRNAi_primary
WBRNAi00084221Inferred_automaticallyRNAi_primary
WBRNAi00110138Inferred_automaticallyRNAi_primary
WBRNAi00093169Inferred_automaticallyRNAi_primary
WBRNAi00093429Inferred_automaticallyRNAi_primary
WBRNAi00110082Inferred_automaticallyRNAi_primary
WBRNAi00093172Inferred_automaticallyRNAi_primary
WBRNAi00093427Inferred_automaticallyRNAi_primary
WBRNAi00084618Inferred_automaticallyRNAi_primary
WBRNAi00084217Inferred_automaticallyRNAi_primary
WBRNAi00093077Inferred_automaticallyRNAi_primary
WBRNAi00071096Inferred_automaticallyRNAi_primary
WBRNAi00081292Inferred_automaticallyRNAi_primary
WBRNAi00093095Inferred_automaticallyRNAi_primary
WBRNAi00084619Inferred_automaticallyRNAi_primary
WBRNAi00114333Inferred_automaticallyRNAi_primary
WBRNAi00114337Inferred_automaticallyRNAi_primary
WBRNAi00110137Inferred_automaticallyRNAi_primary
WBRNAi00093672Inferred_automaticallyRNAi_primary
WBRNAi00056797Inferred_automaticallyRNAi_primary
WBRNAi00084584Inferred_automaticallyRNAi_primary
WBRNAi00084590Inferred_automaticallyRNAi_primary
WBRNAi00093432Inferred_automaticallyRNAi_primary
WBRNAi00116044Inferred_automaticallyRNAi_primary
WBRNAi00110087Inferred_automaticallyRNAi_primary
WBRNAi00110088Inferred_automaticallyRNAi_primary
WBRNAi00093635Inferred_automaticallyRNAi_primary
WBRNAi00108453Inferred_automaticallyRNAi_primary
WBRNAi00093103Inferred_automaticallyRNAi_primary
WBRNAi00084602Inferred_automaticallyRNAi_primary
WBRNAi00110141Inferred_automaticallyRNAi_primary
WBRNAi00000128Inferred_automaticallyRNAi_primary
WBRNAi00110086Inferred_automaticallyRNAi_primary
WBRNAi00110135Inferred_automaticallyRNAi_primary
WBRNAi00064959Inferred_automaticallyRNAi_primary
WBRNAi00084218Inferred_automaticallyRNAi_primary
WBRNAi00117225Inferred_automaticallyRNAi_primary
WBRNAi00093662Inferred_automaticallyRNAi_primary
WBRNAi00001115Inferred_automaticallyRNAi_primary
WBRNAi00110134Inferred_automaticallyRNAi_primary
WBRNAi00110142Inferred_automaticallyRNAi_primary
WBRNAi00066251Inferred_automaticallyRNAi_primary
WBRNAi00110130Inferred_automaticallyRNAi_primary
WBRNAi00117226Inferred_automaticallyRNAi_primary
WBRNAi00004651Inferred_automaticallyRNAi_primary
WBRNAi00084220Inferred_automaticallyRNAi_primary
WBRNAi00093183Inferred_automaticallyRNAi_primary
WBRNAi00026739Inferred_automaticallyRNAi_primary
WBRNAi00084587Inferred_automaticallyRNAi_primary
WBRNAi00026738Inferred_automaticallyRNAi_primary
WBRNAi00093167Inferred_automaticallyRNAi_primary
WBRNAi00110119Inferred_automaticallyRNAi_primary
WBRNAi00110080Inferred_automaticallyRNAi_primary
WBRNAi00093076Inferred_automaticallyRNAi_primary
WBRNAi00066219Inferred_automaticallyRNAi_primary
WBRNAi00110112Inferred_automaticallyRNAi_primary
WBRNAi00084614Inferred_automaticallyRNAi_primary
WBRNAi00093164Inferred_automaticallyRNAi_primary
WBRNAi00084603Inferred_automaticallyRNAi_primary
WBRNAi00110140Inferred_automaticallyRNAi_primary
WBRNAi00110402Inferred_automaticallyRNAi_primary
WBRNAi00084223Inferred_automaticallyRNAi_primary
WBRNAi00093663Inferred_automaticallyRNAi_primary
WBRNAi00093685Inferred_automaticallyRNAi_primary
WBRNAi00084589Inferred_automaticallyRNAi_primary
WBRNAi00084613Inferred_automaticallyRNAi_primary
WBRNAi00093688Inferred_automaticallyRNAi_primary
WBRNAi00093078Inferred_automaticallyRNAi_primary
WBRNAi00110085Inferred_automaticallyRNAi_primary
WBRNAi00084592Inferred_automaticallyRNAi_primary
WBRNAi00110081Inferred_automaticallyRNAi_primary
WBRNAi00084378Inferred_automaticallyRNAi_primary
WBRNAi00084583Inferred_automaticallyRNAi_primary
WBRNAi00112539Inferred_automaticallyRNAi_primary
WBRNAi00110133Inferred_automaticallyRNAi_primary
WBRNAi00110115Inferred_automaticallyRNAi_primary
WBRNAi00066246Inferred_automaticallyRNAi_primary
WBRNAi00085773Inferred_automaticallyRNAi_primary
WBRNAi00110079Inferred_automaticallyRNAi_primary
WBRNAi00110084Inferred_automaticallyRNAi_primary
WBRNAi00093092Inferred_automaticallyRNAi_primary
WBRNAi00093431Inferred_automaticallyRNAi_primary
WBRNAi00093693Inferred_automaticallyRNAi_primary
WBRNAi00093426Inferred_automaticallyRNAi_primary
WBRNAi00026740Inferred_automaticallyRNAi_primary
WBRNAi00066180Inferred_automaticallyRNAi_primary
WBRNAi00093176Inferred_automaticallyRNAi_primary
WBRNAi00093676Inferred_automaticallyRNAi_primary
WBRNAi00110929Inferred_automaticallyRNAi_primary
WBRNAi00110404Inferred_automaticallyRNAi_primary
WBRNAi00093692Inferred_automaticallyRNAi_primary
WBRNAi00084222Inferred_automaticallyRNAi_primary
WBRNAi00110928Inferred_automaticallyRNAi_primary
WBRNAi00110121Inferred_automaticallyRNAi_primary
WBRNAi00116691Inferred_automaticallyRNAi_primary
WBRNAi00066304Inferred_automaticallyRNAi_primary
WBRNAi00037182Inferred_automaticallyRNAi_primary
WBRNAi00110122Inferred_automaticallyRNAi_primary
WBRNAi00110114Inferred_automaticallyRNAi_primary
WBRNAi00108456Inferred_automaticallyRNAi_primary
WBRNAi00093430Inferred_automaticallyRNAi_primary
WBRNAi00093694Inferred_automaticallyRNAi_primary
WBRNAi00084219Inferred_automaticallyRNAi_primary
WBRNAi00110109Inferred_automaticallyRNAi_primary
WBRNAi00110120Inferred_automaticallyRNAi_primary
Expr_patternExpr4061
Expr1015221
Expr1032476
Expr1160254
Expr2016053
Expr2034288
Regulate_expr_clusterWBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
Microarray_results (20)
Expression_cluster (117)
Interaction (149)
WBProcessWBbiopr:00000077
WBbiopr:00000079
Map_infoMapIPosition-3.21963Error0.03887
Hide_underWBGene00002709
PositivePositive_cloneY47G6AInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
NegativeOutside_rearrhDf24
Mapping_dataMulti_point5016
Pos_neg_data8616
8617
8618
8619
Pseudo_map_position
Reference (41)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene