| WBGene00004972 | SMap | S_parent | Sequence | R10H10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | spe-26 | Person_evidence | WBPerson252 |
| | | Sequence_name | R10H10.2 |
| | | Molecular_name | R10H10.2 |
| | | | R10H10.2.1 |
| | | | CE06293 |
| | | Other_name | CELE_R10H10.2 | Accession_evidence | NDB | BX284604 |
| | | Public_name | spe-26 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | spe |
| | Allele (33) |
| | Legacy_information | [C.elegansII] hc138 : accumulates defective spermatocytes; pleiotropic effects in increasing lifespan, thermotolerance, UV resistance. OA5: hc139, hc140, it112, it118, hc107ts( Spe, non-Age).5/6 alleles ts. Cloned: encodes 570 aa protein containing 5 tandem 50 aa scruin/kelch repeats, possible actin-binding domains. [Van Voorhies 1992; Varkey et al. 1995; BA; HU; KK] |
| | | [Varkey JP] hc138 rescued by 6.5 kb HindIII fragment from C26H10. Predicted gene R10H10.2 |
| | Strain (12) |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00056371 |
| | | 00056372 |
| | | 00056373 |
| | | 00056374 |
| | Ortholog (31) |
| | Paralog (11) |
| | Structured_description | Concise_description | spe-26 encodes a Kelch motif-containing protein similar to the Drosophila proteins kelch and diablo and the Limulus (horseshoe crab) actin-bundling protein scruin; SPE-26 activity is required for several processes including embryogenesis, spermatogenesis, thermotolerance, and regulation of lifespan; SPE-26 mRNA is detected in spermatogonial cells and spermatocytes, but not in spermatids. | Paper_evidence | WBPaper00002181 |
| | | | | | WBPaper00004651 |
| | | | | | WBPaper00020755 |
| | | | | | WBPaper00021636 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable actin binding activity. Predicted to be located in cytoplasm and cytoskeleton. Expressed in spermatocyte and in male. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Is an ortholog of human KLHL10 (kelch like family member 10). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0070180 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:18829) |
| Molecular_info | Corresponding_CDS | R10H10.2 |
| | Corresponding_transcript | R10H10.2.1 |
| | Other_sequence | CJC18311_1 |
| | Associated_feature | WBsf230728 |
| Experimental_info | RNAi_result (20) |
| | Expr_pattern | Expr1550 |
| | | Expr1028235 |
| | | Expr1032473 |
| | | Expr1155404 |
| | | Expr2016036 |
| | | Expr2034270 |
| | Drives_construct | WBCnstr00035299 |
| | Construct_product | WBCnstr00035299 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00038237:age-1_upregulated_intestine_rescue |
| | | WBPaper00038237:age-1_upregulated_neuron_rescue |
| | | WBPaper00038237:age-1_upregulated_nontransgenic |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00041954:ethanol_upregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044037:eat-2_upregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_upregulated |
| | | WBPaper00044616:alg-3-4_downregulated_gene |
| | | WBPaper00044736:rising_dev_expression |
| | | WBPaper00044743:wdr-23_neuron_upregulated |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00044786:lem-2(tm1582)_upregulated |
| | | WBPaper00045050:csr-1(hypomorph)_upregulated |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045809:rsd-2(yp10)_downregulated |
| | | WBPaper00046805:csr-1(RNAi)_upregulated_Set1 |
| | | WBPaper00046805:P-granule-RNAi_upregulated_Set1 |
| | | WBPaper00048762:FOG-3_associated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050231:male_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00051404:alg-1(gk214)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053318:Aging_downregulated_mRNA_N2 |
| | | WBPaper00053318:mir-71(n4115)_downregulated_mRNA |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_upregulated |
| | | WBPaper00053657:JU2519_M.humicola-infection_24hr |
| | | WBPaper00053664:ins-11(tm1053)_upregulated |
| | | WBPaper00054872:egl-9(sa307)_downregulated |
| | | WBPaper00055354:eat-2(ad1116)_downregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055386:daf-2(e1370)_upregulated |
| | | WBPaper00055386:eat-2(ad465)_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055648:sperm_expressed |
| | | WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched |
| | | WBPaper00055862:antimycin_damt-1(gk961032)_regulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056167:Cry5B_downregulated |
| | | WBPaper00056290:hsp-6(mg585)_downregulated |
| | | WBPaper00056809:smn-1(ok355)_downregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057068:numr-1(RNAi)_upregulated_Cadmium |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059605:mut-16(pk710)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_N2 |
| | | WBPaper00060445:ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4 |
| | | WBPaper00060445:nfki-1(cer1)_upregulated_L4 |
| | | WBPaper00060661:hypoxia_upregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00060921:cat-2(e1112)_downregulated |
| | | WBPaper00060921:tbh-1(ok1196)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:ASH |
| | | WBPaper00061340:g2_parent |
| | | WBPaper00061340:hmc_homolog |
| | | WBPaper00061340:PLM |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061424:Diet_MYb131_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061479:hda-1(ne4747)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061479:prg-1(tm872)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:sfxn-1.4-K11H3.2 |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062456:doxycycline_upregulated_CB4856_transcript |
| | | WBPaper00062456:doxycycline_upregulated_N2_transcript |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064494:postdauer_downregulated_AWA |
| | | WBPaper00064539:nhr-114(gk849)_downregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day10_20C |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day10_25C |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065841:12_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065984:pals-17(syb3980)_upregulated |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066038:mip-1(how5)_upregulated |
| | | WBPaper00066085:hda-3(ok1991)_upregulated |
| | | WBPaper00066110:Cisplatin_upregulated_diploid |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066232:ash-2(RNAi)_downregulated_WT |
| | | WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2 |
| | | cgc4489_group_11 |
| | | WBPaper00030985:Erwinia_carotovora_upregulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_E |
| | | WBPaper00038172:aak-2overexpression_up_regulated |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00045263:ProLongevity-mtROS_downregulated |
| | | WBPaper00045673:colistin_downregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated |
| | | [cgc6390]:Cluster_D |
| | | [cgc6390]:spermatogenesis-enriched |
| | Interaction (80) |
| | WBProcess | WBbiopr:00000069 |
| Map_info | Map | IV | Position | 4.58041 | Error | 0.001418 |
| | Well_ordered |
| | Positive | Positive_clone | C26H10 |
| | | | R10H10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 7044 |
| | | | 7045 |
| | | | 7046 |
| | | | 7047 |
| | | | 7048 |
| | | Multi_point | 4373 |
| | | | 4660 |
| | | Pos_neg_data | 8905 |
| | | | 8906 |
| | | | 8907 |
| Reference (58) |
| Remark | Extracted from Varkey et al. (1995) |
| Method | Gene |
