WormBase Tree Display for Gene: WBGene00004914

WBGene00004914 Evidence: Paper_evidence: WBPaper00005457
  SMap: S_parent: Sequence: Y116A8C
  Identity: Version: 1
    Name: CGC_name: snr-1 Person_evidence: WBPerson167
      Sequence_name: Y116A8C.42
      Molecular_name: Y116A8C.42
        Y116A8C.42.1
        CE23346
      Other_name: CELE_Y116A8C.42 Accession_evidence: NDB BX284604
      Public_name: snr-1
    DB_info: Database: AceView gene 4S33
        WormQTL gene WBGene00004914
        WormFlux gene WBGene00004914
        NDB locus_tag CELE_Y116A8C.42
        Panther gene CAEEL|WormBase=WBGene00004914|UniProtKB=Q17348
          family PTHR23338
        NCBI gene 178483
        RefSeq protein NM_070626.7
        SwissProt UniProtAcc Q17348
        TREEFAM TREEFAM_ID TF354302
        UniProt_GCRP UniProtAcc Q17348
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: snr
    Allele (23)
    Strain: WBStrain00001675
      WBStrain00051382
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog (38)
    Paralog: WBGene00003078 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004916 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00044916 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: snr-1 encodes an ortholog of human small nuclear ribonucleoprotein Sm D3, a protein that forms part of a heptameric complex required for the biogenesis and function of the snRNPs that catalyze mRNA splicing; in combination with the gene that encodes the human Sm B ortholog (snr-2) snr-1 affects embryonic viability and the nuclear association and localization of P granules in embryos based on an RNAi assay, snr-1 also affects embryonic viability, growth, and fertility based on large-scale RNAi assays; snr-1 is expressed in embryos and is expressed in larvae and adults in muscles of the alimentary system, in body-wall muscle, in seam cells and other unidentified cells. Paper_evidence: WBPaper00005457
            WBPaper00005654
            WBPaper00006395
          Curator_confirmed: WBPerson48
          Date_last_updated: 11 Jul 2005 00:00:00
      Automated_description: Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in P granule. Expressed in germ line; gonad; head; and tail. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Is an ortholog of human SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11160)
  Molecular_info: Corresponding_CDS: Y116A8C.42
    Corresponding_transcript: Y116A8C.42.1
    Other_sequence (61)
    Associated_feature: WBsf655067
      WBsf981869
  Experimental_info: RNAi_result (34)
    Expr_pattern: Expr2229
      Expr3827
      Expr6893
      Expr1013438
      Expr1032443
      Expr1158970
      Expr2015965
      Expr2034200
    Drives_construct: WBCnstr00002339
      WBCnstr00011678
    Construct_product: WBCnstr00011678
    Antibody: WBAntibody00000549
      WBAntibody00000550
      WBAntibody00000551
      WBAntibody00000552
      WBAntibody00000553
    Microarray_results (28)
    Expression_cluster: WBPaper00032528:L3_enriched
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
      WBPaper00042477:RSR-2_complex
      WBPaper00044128:DietaryRestriction_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045774:clk-1_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00048810:CoQ-deficiency_downregulated
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050193:cec-4(ok3124)_downregulated_L1
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050412:cco-1(RNAi)_downregulated_N2
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00051555:atm-1(gk186)_regulated_protein
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055827:daf-2(e1370)_downregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00056900:PID-3_interacting
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_downregulated_protein
      WBPaper00059567:olrn-1(ums9)_regulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061045:Y56A3A.22(cck200)_downregulated
      WBPaper00061199:GYF-1_interacting
      WBPaper00061340:AMso_parent
      WBPaper00061340:ASE_parent
      WBPaper00061340:DVC_parent
      WBPaper00061340:I1_parent
      WBPaper00061340:Neuroblast_ALM_BDU
      WBPaper00061340:Neuroblast_ASG_AWA
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:snr-3-rbx-1
      WBPaper00061651:Germline_enriched
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00063976:micu-1(bon20)_downregulated
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064080:let-7_miRNA_interacting
      WBPaper00064080:miR-58_miRNA_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_downregulated_protein
      WBPaper00064201:SNA-1_interacting
      WBPaper00064315:mes-4(bn73)_downregulated_PGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00064992:Capsaicin_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4489_group_4
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Enriched_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00030839:Embryo_A_Class
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00032948:FedUp
      WBPaper00034661:AgNPs_upregulated
      WBPaper00036286:Pattern_F
      WBPaper00036375:depleted_in_PVD_OLL
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045673:colistin_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc6390]:oogenesis-enriched
    Interaction (323)
  Map_info: Map: IV Position: 16.1295 Error: 0.005659
    Positive: Positive_clone: Y116A8C Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005457
    WBPaper00026926
    WBPaper00038491
    WBPaper00040897
    WBPaper00046572
    WBPaper00049828
    WBPaper00055090
    WBPaper00063976
    WBPaper00064034
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene