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WormBase Tree Display for Gene: WBGene00004862

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Name Class

WBGene00004862EvidencePaper_evidenceWBPaper00013343
SMapS_parentSequenceT05A10
IdentityVersion1
NameCGC_namesma-9Person_evidenceWBPerson261
Sequence_nameT05A10.1
Molecular_name (38)
Other_nameCELE_T05A10.1Accession_evidenceNDBBX284606
Public_namesma-9
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsma
Allele (216)
Legacy_information[Savage-Dunn C] Small and Mab (sensory ray and spicule abnormalities).
Complementation_data[Savage-Dunn C] complements sma-5(n678)
Strain (18)
RNASeq_FPKM (74)
GO_annotation (41)
Contained_in_operonCEOPX001
OrthologWBGene00037178Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00149616Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00058412Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00120325Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00225829Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g3560Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g10188Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g3097Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g5516Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g15967Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g25181Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP31.g5374Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g2084Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g21731Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g8500Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g19901Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_02513.g17271Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-sma-9Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g13804Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00044.g2345Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_01259Caenorhabditis latensFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g04482Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g10941Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_X0076300Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrX_pilon.g19946Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00240359Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00111383Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00273915Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00257341Strongyloides rattiFrom_analysisWormBase-Compara
FB:FBgn0003396Drosophila melanogasterFrom_analysisInparanoid
OrthoFinder
OrthoInspector
ZFIN:ZDB-GENE-041014-354Danio rerioFrom_analysisOrthoFinder
OrthoInspector
ZFIN:ZDB-GENE-070912-512Danio rerioFrom_analysisOrthoFinder
OrthoInspector
ZFIN:ZDB-GENE-130530-562Danio rerioFrom_analysisOrthoFinder
OrthoInspector
ZFIN:ZDB-GENE-081029-2Danio rerioFrom_analysisOrthoFinder
OrthoInspector
HGNC:4920Homo sapiensFrom_analysisOrthoFinder
OrthoInspector
HGNC:4921Homo sapiensFrom_analysisOrthoFinder
OrthoInspector
HGNC:13561Homo sapiensFrom_analysisOrthoFinder
OrthoInspector
MGI:1338076Mus musculusFrom_analysisOrthoFinder
OrthoInspector
MGI:106589Mus musculusFrom_analysisOrthoFinder
OrthoInspector
MGI:96100Mus musculusFrom_analysisOrthoFinder
OrthoInspector
RGD:61988Rattus norvegicusFrom_analysisOrthoFinder
OrthoInspector
RGD:727847Rattus norvegicusFrom_analysisOrthoFinder
OrthoInspector
RGD:1311252Rattus norvegicusFrom_analysisOrthoFinder
OrthoInspector
Structured_descriptionConcise_descriptionsma-9 encodes, by extensive alternative splicing, at least 13 isoforms, a number of which are large (~2000-residue) proteins with at least three N-terminal involucrin domains, seven C-terminal zinc-finger domains, and a glutamine/asparagine-rich domain; SMA-9 is orthologous to the Drosophila Smad cofactor Schnurri (FBgn0003396) and the vertebrate HIVEP proteins (Human Immunodeficiency Virus Type 1 Enhancer-Binding Proteins, OMIM:194540, OMIM:143054, and OMIM:606649); in C. elegans, sma-9 functions in a subset of the TGF-beta-mediated signaling pathways that regulate body size and male tail patterning and morphogenesis; sma-9, through this pathway, also regulates reproductive aging; studies have shown that a reduction of TGF-beta pathway genes extends reproductive span by maintaining oocyte and germline quality; sma-9 also functions antagonistically to the TGF-beta signaling pathway, and in parallel to the lin-12/Notch pathway, to effect proper cell fate specification in the postembryonic mesodermal lineage, the M lineage; SMA-9 is widely expressed and localizes to nuclei.Paper_evidenceWBPaper00005858
WBPaper00006346
WBPaper00027702
WBPaper00029226
WBPaper00035079
WBPaper00035556
WBPaper00037682
Curator_confirmedWBPerson1843
WBPerson324
WBPerson567
Date_last_updated18 Jan 2011 00:00:00
Automated_descriptionEnables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to heat. Located in nucleus. Expressed in several structures, including excretory cell; intestine; spermatheca; ventral cord neurons; and vulva. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Is an ortholog of human HIVEP1 (HIVEP zinc finger 1); HIVEP2 (HIVEP zinc finger 2); and HIVEP3 (HIVEP zinc finger 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:10652Homo sapiensPaper_evidenceWBPaper00046027
Curator_confirmedWBPerson324
Date_last_updated21 Sep 2018 00:00:00
Potential_modelDOID:0070073Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4921)
Models_disease_in_annotationWBDOannot00000341
Molecular_infoCorresponding_CDS (11)
Corresponding_CDS_history (13)
Corresponding_transcript (16)
Other_sequence (328)
Associated_feature (25)
Gene_product_binds (41)
Transcription_factorWBTranscriptionFactor000847
Experimental_infoRNAi_result (21)
Expr_patternExpr2782
Expr2783
Expr3995
Expr10436
Expr1011744
Expr1032413
Expr1156052
Expr1200018
Expr2015897
Expr2034130
Drives_construct (15)
Construct_product (11)
AntibodyWBAntibody00000885
Microarray_results (83)
Expression_cluster (163)
Interaction (82)
WBProcessWBbiopr:00000025
WBbiopr:00000026
WBbiopr:00000033
Map_infoMapXPosition2.51785Error0.028298
PositiveInside_rearrnDf19
yDp9
Positive_cloneT05A10Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeOutside_rearrmnDp1
mnDf1
yDp5
Mapping_data2_point7096
7097
7099
Pos_neg_data10243
10244
10245
10246
10247
Reference (61)
PictureWBPicture0000013077
MethodGene