WormBase Tree Display for Gene: WBGene00004729

WBGene00004729 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 2
    Name: CGC_name: sax-3 Person_evidence: WBPerson42
      Sequence_name: ZK377.2
      Molecular_name: ZK377.2a
        ZK377.2a.1
        CE25688
        ZK377.2b
        CE31267
        ZK377.2b.1
      Other_name: CELE_ZK377.2 Accession_evidence: NDB BX284606
      Public_name: sax-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 02 Mar 2018 11:09:16 WBPerson4025 Event: Split_into: WBGene00303098
      Split_into: WBGene00303098
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sax
    Allele (171)
    Legacy_information: [Zallen JA] ky123 recessive, homozygotes exhibit aberrant anterior position of nerve ring, many ring axons misrouted, ventral nerve cord neurons often misrouted, cross midline. Encodes three isoforms, longest 1273 aa with 5 Ig repeats, 3 FNIII repeats, TM domain, large cytoplasmic domain. ky123 deletes signal sequence and first exon, probable null. Predicted gene ZK377.3 + ZK377.2
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog: WBGene00034790 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00051982 Caenorhabditis remanei From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00148619 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00128991 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00104171 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00227726 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2329 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g12021 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g3884 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g10471 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g5898 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g8996 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5061 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g9460 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g25465 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g16259 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00024.g1476 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_09429.g22059 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sax-3 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_X.g23886 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18177 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00313.g9231 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00818.g15761 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00829 Caenorhabditis latens From_analysis: WormBase-Compara
      FL83_00830 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024104 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12222 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12223 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g8691 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0269800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18763 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00242200 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00267281 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00302741 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0041097 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
      FB:FBgn0005631 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      FB:FBgn0002543 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            PhylomeDB
      ZFIN:ZDB-GENE-000209-3 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-000209-4 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-001019-1 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1874 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:10249 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:10250 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:13433 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1343102 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:1274781 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
      MGI:1890110 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:61941 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:620167 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:1311018 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            SonicParanoid
    Paralog (22)
    Structured_description: Concise_description: sax-3 encodes, by alternative splicing, two isoforms of an ortholog of Drosophila ROUNDABOUT, ROBO3, and LEAK, and of human ROBO1, ROBO2 (OMIM:602431, mutated in vesicoureteral reflux), and ROBO3 (OMIM:608630, mutated in horizontal gaze palsy with progressive scoliosis); in larval hermaphrodites, SAX-3 is required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Paper_evidence: WBPaper00003665
            WBPaper00004362
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 24 Jan 2008 00:00:00
      Automated_description: Enables axon guidance receptor activity. Involved in generation of neurons and regulation of sensory neuron axon guidance. Located in plasma membrane. Expressed in several structures, including QR.a; QR.p; body wall musculature; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital nystagmus; hematologic cancer (multiple); and myositis (multiple). Is an ortholog of human ROBO1 (roundabout guidance receptor 1); ROBO2 (roundabout guidance receptor 2); and ROBO3 (roundabout guidance receptor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (11)
  Molecular_info: Corresponding_CDS: ZK377.2a
      ZK377.2b
    Corresponding_CDS_history: ZK377.2c:wp264
    Corresponding_transcript: ZK377.2a.1
      ZK377.2b.1
    Other_sequence (32)
    Associated_feature: WBsf670328
      WBsf670329
      WBsf670330
      WBsf670331
      WBsf670332
      WBsf670333
      WBsf670334
      WBsf670335
      WBsf670336
      WBsf670337
      WBsf670338
      WBsf670339
      WBsf670340
      WBsf1004619
      WBsf1004620
      WBsf1004621
      WBsf1004622
      WBsf1004623
      WBsf1004624
      WBsf1004625
      WBsf1004626
      WBsf1004627
      WBsf1004628
      WBsf1004629
      WBsf1004630
      WBsf1004631
      WBsf1004632
      WBsf1004633
      WBsf1022612
      WBsf1022613
      WBsf1022614
      WBsf1022615
      WBsf1022616
      WBsf1022617
      WBsf1022618
      WBsf1022619
      WBsf1022620
      WBsf1022621
      WBsf237183
  Experimental_info: RNAi_result: WBRNAi00086088 Inferred_automatically: RNAi_primary
      WBRNAi00086133 Inferred_automatically: RNAi_primary
      WBRNAi00009468 Inferred_automatically: RNAi_primary
      WBRNAi00009467 Inferred_automatically: RNAi_primary
      WBRNAi00067130 Inferred_automatically: RNAi_primary
      WBRNAi00059385 Inferred_automatically: RNAi_primary
    Expr_pattern (17)
    Drives_construct: WBCnstr00001914
      WBCnstr00003185
      WBCnstr00006455
      WBCnstr00009445
      WBCnstr00012503
      WBCnstr00016209
      WBCnstr00035424
      WBCnstr00039977
      WBCnstr00041184
    Construct_product (15)
    Microarray_results (28)
    Expression_cluster (134)
    Interaction (262)
    Anatomy_function: WBbtf0177
  Map_info: Map: X Position: -10.3398 Error: 0.007528
    Well_ordered
    Positive: Inside_rearr: mnDp57
      Positive_clone: R06A1
        ZK377 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3695
        3696
        4758
      Pos_neg_data: 9401
  Reference (143)
  Remark: Inferred from Zallen et al. (1998)
    2 predicted genes (see phenotype) have been merged. [sdm 05/00]
  Method: Gene