WormBase Tree Display for Gene: WBGene00004701

WBGene00004701 SMap: S_parent: Sequence: EEED8
  Identity: Version: 1
    Name: CGC_name: rsp-4 Person_evidence: WBPerson297
      Sequence_name: EEED8.7
      Molecular_name: EEED8.7a
        EEED8.7a.1
        CE01891
        EEED8.7b
        CE27910
        EEED8.7b.1
        EEED8.7b.2
      Other_name: srp-2
        CeSC35
        CELE_EEED8.7 Accession_evidence: NDB BX284602
      Public_name: rsp-4
    DB_info: Database: AceView gene 2F678
        WormQTL gene WBGene00004701
        WormFlux gene WBGene00004701
        NDB locus_tag CELE_EEED8.7
        Panther gene CAEEL|WormBase=WBGene00004701|UniProtKB=Q09511
          family PTHR23147
        NCBI gene 173915
        RefSeq protein NM_001393068.1
            NM_062613.4
        SwissProt UniProtAcc Q09511
        TREEFAM TREEFAM_ID TF106262
        UniProt_GCRP UniProtAcc Q09511
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rsp
    Allele (22)
    Strain: WBStrain00047545
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP2743
    Ortholog (36)
    Paralog: WBGene00004315 Caenorhabditis elegans From_analysis: Panther
      WBGene00004703 Caenorhabditis elegans From_analysis: Panther
      WBGene00013293 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: rsp-4 encodes, along with rsp-5, one of two C. elegans orthologs of the vertebrate SC35 splicing factor and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation. Paper_evidence: WBPaper00003988
          Curator_confirmed: WBPerson1843
          Date_last_updated: 20 Mar 2012 00:00:00
      Automated_description: Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); and lung cancer (multiple). Is an ortholog of human SRSF2 (serine and arginine rich splicing factor 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4467 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
      DOID:6000 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
      DOID:0050908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
      DOID:5410 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
      DOID:3907 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10783)
  Molecular_info: Corresponding_CDS: EEED8.7a
      EEED8.7b
    Corresponding_transcript: EEED8.7a.1
      EEED8.7b.1
      EEED8.7b.2
    Other_sequence (52)
    Associated_feature: WBsf987876
      WBsf1012225
      WBsf223040
      WBsf223041
      WBsf223042
  Experimental_info: RNAi_result (30)
    Expr_pattern: Expr1140
      Expr1022567
      Expr1032321
      Expr1147687
      Expr2015561
      Expr2033796
    Drives_construct: WBCnstr00010102
      WBCnstr00035432
    Construct_product: WBCnstr00035432
    Microarray_results (30)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032097:CGH-1-associated-mRNA
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045420:fertilization_upregulated_protein
      WBPaper00045774:clk-1_downregulated
      WBPaper00045971:tunicamycin_upregulated_control
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046887:WNT-target
      WBPaper00048644:germline_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_3
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050182:lmn-1(L535P)_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060459:bcat-1(RNAi)_downregulated
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061274:hypergravity_10xg_upregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061527:rsp-4_18519-htz-1_18194
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00063976:micu-1(bon20)_upregulated
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064122:vulva_transcriptome
      WBPaper00064201:SNA-3_interacting
      WBPaper00064716:paraquat_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_2
      cgc4489_group_4
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00032948:FedUp
      WBPaper00035227:heat_shock_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00037147:heatshock_upregulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:TA300_down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_downregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00045960:L4-lethargus_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00050538:Fasting_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(66_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc6390]:intrinsic
    Interaction: WBInteraction000031122
      WBInteraction000051895
      WBInteraction000106445
      WBInteraction000106661
      WBInteraction000106680
      WBInteraction000106705
      WBInteraction000106706
      WBInteraction000106707
      WBInteraction000106708
      WBInteraction000106709
      WBInteraction000106710
      WBInteraction000106711
      WBInteraction000106712
      WBInteraction000106713
      WBInteraction000106714
      WBInteraction000106715
      WBInteraction000106716
      WBInteraction000106717
      WBInteraction000106718
      WBInteraction000106748
      WBInteraction000106910
      WBInteraction000107032
      WBInteraction000108661
      WBInteraction000108662
      WBInteraction000108663
      WBInteraction000108664
      WBInteraction000108665
      WBInteraction000108669
      WBInteraction000125035
      WBInteraction000125426
      WBInteraction000125427
      WBInteraction000125428
      WBInteraction000125429
      WBInteraction000125451
      WBInteraction000128633
      WBInteraction000128640
      WBInteraction000130148
      WBInteraction000130149
      WBInteraction000130150
      WBInteraction000130151
      WBInteraction000130152
      WBInteraction000130153
      WBInteraction000130154
      WBInteraction000130155
      WBInteraction000130156
      WBInteraction000130157
      WBInteraction000130158
      WBInteraction000130159
      WBInteraction000130160
      WBInteraction000130161
      WBInteraction000130162
      WBInteraction000130163
      WBInteraction000130164
      WBInteraction000130165
      WBInteraction000130166
      WBInteraction000130167
      WBInteraction000130168
      WBInteraction000130169
      WBInteraction000130170
      WBInteraction000130171
      WBInteraction000130172
      WBInteraction000130173
      WBInteraction000130174
      WBInteraction000130175
      WBInteraction000130176
      WBInteraction000130177
      WBInteraction000130178
      WBInteraction000130179
      WBInteraction000130180
      WBInteraction000130181
      WBInteraction000130182
      WBInteraction000130247
      WBInteraction000130728
      WBInteraction000130882
      WBInteraction000130969
      WBInteraction000131044
      WBInteraction000131852
      WBInteraction000131965
      WBInteraction000132105
      WBInteraction000158734
      WBInteraction000158808
      WBInteraction000158809
      WBInteraction000158810
      WBInteraction000158811
      WBInteraction000158812
      WBInteraction000158813
      WBInteraction000158814
      WBInteraction000159096
      WBInteraction000162499
      WBInteraction000200710
      WBInteraction000200886
      WBInteraction000220484
      WBInteraction000223528
      WBInteraction000227517
      WBInteraction000231345
      WBInteraction000251054
      WBInteraction000263437
      WBInteraction000275782
      WBInteraction000278074
      WBInteraction000285855
      WBInteraction000310925
      WBInteraction000314367
      WBInteraction000336995
      WBInteraction000339562
      WBInteraction000339783
      WBInteraction000358312
      WBInteraction000361603
      WBInteraction000375697
      WBInteraction000402606
      WBInteraction000411939
      WBInteraction000413569
      WBInteraction000431775
      WBInteraction000443946
      WBInteraction000446038
      WBInteraction000448522
      WBInteraction000576719
      WBInteraction000586051
  Map_info: Map: II Position: -1.7847 Error: 0.000271
    Positive: Positive_clone: EEED8 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4588
    Pseudo_map_position
  Reference (14)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene