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WormBase Tree Display for Gene: WBGene00004701

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Name Class

WBGene00004701SMapS_parentSequenceEEED8
IdentityVersion1
NameCGC_namersp-4Person_evidenceWBPerson297
Sequence_nameEEED8.7
Molecular_nameEEED8.7a
EEED8.7a.1
CE01891
EEED8.7b
CE27910
EEED8.7b.1
EEED8.7b.2
Other_namesrp-2
CeSC35
CELE_EEED8.7Accession_evidenceNDBBX284602
Public_namersp-4
DB_infoDatabaseAceViewgene2F678
WormQTLgeneWBGene00004701
WormFluxgeneWBGene00004701
NDBlocus_tagCELE_EEED8.7
PanthergeneCAEEL|WormBase=WBGene00004701|UniProtKB=Q09511
familyPTHR23147
NCBIgene173915
RefSeqproteinNM_001393068.1
NM_062613.4
SwissProtUniProtAccQ09511
TREEFAMTREEFAM_IDTF106262
UniProt_GCRPUniProtAccQ09511
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:36WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classrsp
Allele (22)
StrainWBStrain00047545
RNASeq_FPKM (74)
GO_annotation (16)
Contained_in_operonCEOP2743
Ortholog (36)
ParalogWBGene00004315Caenorhabditis elegansFrom_analysisPanther
WBGene00004703Caenorhabditis elegansFrom_analysisPanther
WBGene00013293Caenorhabditis elegansFrom_analysisPanther
Structured_descriptionConcise_descriptionrsp-4 encodes, along with rsp-5, one of two C. elegans orthologs of the vertebrate SC35 splicing factor and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation.Paper_evidenceWBPaper00003988
Curator_confirmedWBPerson1843
Date_last_updated20 Mar 2012 00:00:00
Automated_descriptionPredicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hematologic cancer (multiple); and lung cancer (multiple). Is an ortholog of human SRSF2 (serine and arginine rich splicing factor 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:4467Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
DOID:6000Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
DOID:0050908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
DOID:3910Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
DOID:5410Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
DOID:3907Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
DOID:9119Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10783)
Molecular_infoCorresponding_CDSEEED8.7a
EEED8.7b
Corresponding_transcriptEEED8.7a.1
EEED8.7b.1
EEED8.7b.2
Other_sequence (52)
Associated_featureWBsf987876
WBsf1012225
WBsf223040
WBsf223041
WBsf223042
Experimental_infoRNAi_result (30)
Expr_patternExpr1140
Expr1022567
Expr1032321
Expr1147687
Expr2015561
Expr2033796
Drives_constructWBCnstr00010102
WBCnstr00035432
Construct_productWBCnstr00035432
Microarray_results (30)
Expression_clusterWBPaper00031040:TGF-beta_adult_downregulated
WBPaper00032097:CGH-1-associated-mRNA
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
WBPaper00042194:nhr-114(RNAi)_upregulated
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00044760:germline_specific
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
WBPaper00045420:fertilization_upregulated_protein
WBPaper00045774:clk-1_downregulated
WBPaper00045971:tunicamycin_upregulated_control
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046887:WNT-target
WBPaper00048644:germline_enriched
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:cco-1(RNAi)_downregulated
WBPaper00049545:jmjd-3.1(+)_downregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
WBPaper00050182:lmn-1(L535P)_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:body-muscle_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_nucleus_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_nucleus_expressed
WBPaper00051245:nucleus_specific
WBPaper00052987:UV_upregulated_xpc-1;csb-1
WBPaper00053295:lin-22(ot269)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00053388:dauer_regulated_Cluster6
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00055648:germline_expressed
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056284:ints-5(RNAi)_downregulated
WBPaper00057041:spc-1(cas971)_upregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057288:Cold_downregulated_protein
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061274:hypergravity_10xg_upregulated
WBPaper00061274:hypergravity_15xg_upregulated
WBPaper00061527:cids-2_2203-attf-2_2451
WBPaper00061527:rsp-4_18519-htz-1_18194
WBPaper00062159:hda-2(ok1479)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062554:MAGU-2_interacting
WBPaper00063976:micu-1(bon20)_upregulated
WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_downregulated_N2_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064122:vulva_transcriptome
WBPaper00064201:SNA-3_interacting
WBPaper00064716:paraquat_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
cgc4386_cluster_6_2
cgc4489_group_4
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00032948:FedUp
WBPaper00035227:heat_shock_regulated
WBPaper00035905:FBF-1_Associated
WBPaper00037147:heatshock_upregulated
WBPaper00037901:GLD-1_mRNA_targets
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
WBPaper00040858:eQTL_regulated_old
WBPaper00040963:TA300_down
WBPaper00041002:HF_3d_2.0mM_Down
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:isp-1(qm150)_downregulated
WBPaper00045263:nuo-6(qm200)_downregulated
WBPaper00045960:L4-lethargus_downregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00050538:Fasting_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(66_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:intrinsic
Interaction (117)
Map_infoMapIIPosition-1.7847Error0.000271
PositivePositive_cloneEEED8Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4588
Pseudo_map_position
Reference (14)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene