WormBase Tree Display for Gene: WBGene00004700

WBGene00004700 SMap: S_parent: Sequence: Y111B2A
  Identity: Version: 1
    Name: CGC_name: rsp-3 Person_evidence: WBPerson297
      Sequence_name: Y111B2A.18
      Molecular_name: Y111B2A.18
        Y111B2A.18.1
        CE31089
        Y111B2A.18.2
      Other_name: CeSF2/ASF
        CeSF2
        Y111B2G.i Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y111B2A.18 Accession_evidence: NDB BX284603
      Public_name: rsp-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rsp
    Allele (40)
    Strain: WBStrain00001377
      WBStrain00002707
      WBStrain00037218
    RNASeq_FPKM (74)
    GO_annotation (18)
    Ortholog (44)
    Paralog: WBGene00004698 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004699 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004702 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00013307 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020399 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: rsp-3 encodes an ortholog of human SF2/ASF and member of the SR protein family of nuclear phosphoproteins that are required for constitutive splicing and influence alternative splicing regulation; rsp-3 affects the development of oocytes together with rsr-1, and is required for late embryonic viability; SPK-1 binds directly to and phosphorylates the RS domain of RSP-3 in vitro; the rsp-3 mRNA is predominantly expressed in the germline. Paper_evidence: WBPaper00003988
            WBPaper00004476
            WBPaper00005023
            WBPaper00005654
            WBPaper00006395
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable RNA binding activity. Involved in embryo development. Predicted to be located in nuclear speck. Expressed in PVDL; PVDR; and gonad. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); lung non-small cell carcinoma (multiple); and urinary system cancer (multiple). Is an ortholog of human SRSF1 (serine and arginine rich splicing factor 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (12)
  Molecular_info: Corresponding_CDS: Y111B2A.18
    Corresponding_CDS_history: Y111B2A.18:wp80
    Corresponding_transcript: Y111B2A.18.1
      Y111B2A.18.2
    Other_sequence (244)
    Associated_feature: WBsf655406
      WBsf667543
      WBsf667544
      WBsf981628
      WBsf1016237
      WBsf227677
      WBsf227678
      WBsf227679
      WBsf227680
      WBsf227681
  Experimental_info: RNAi_result (22)
    Expr_pattern: Expr1129
      Expr6885
      Expr6886
      Expr12217
      Expr12228
      Expr1013527
      Expr1032320
      Expr1158880
      Expr2015560
      Expr2033795
    Drives_construct: WBCnstr00002268
      WBCnstr00003248
      WBCnstr00020416
    Construct_product: WBCnstr00020471
    Microarray_results (25)
    Expression_cluster: WBPaper00005943:L4_specific
      WBPaper00028451:Abundant_spermatogenesis_enriched
      WBPaper00035269:cde-1_regulated
      WBPaper00037047:insoluble_protein
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00038118:stress_upregulated_N2
      WBPaper00038289:oocyte_protein
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044128:DietaryRestriction_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045257:bar-1(ga80)_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_downregulated
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046303:P.aeruginosa_downregulated_protein
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00048910:mRNA-interacting_protein
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_nucleus_expressed
      WBPaper00051245:nucleus_specific
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053289:DREAM-target
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster6
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:isp-1(qm150)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00053814:25C_downregulated_OP50
      WBPaper00053814:25C_downregulated_PY79
      WBPaper00055049:S.gordonii_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058725:sftb-1(cer6)_upregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059605:MUT-16_interacting
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060908:TEBP-1_interacting
      WBPaper00060908:TEBP-2_interacting
      WBPaper00061007:HB101_downregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061274:hypergravity_15xg_upregulated
      WBPaper00061340:hyp1V_and_ant_arc_V
      WBPaper00061340:Neuroblast_ASJ_AUA
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:AFFX-r2-3487-3_s_at-tba-1
      WBPaper00061527:cids-2_2203-attf-2_2451
      WBPaper00061527:R07E4.5-skp-1_1608
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062554:MAGU-2_interacting
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064156:lbp-3(overexpress)_downregulated
      WBPaper00064163:ZNFX-1_interacting_young-adult
      WBPaper00064201:SNA-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064716:paraquat_upregulated
      WBPaper00064871:hypoxia_upregulated_F1
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_Ref
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_3
      cgc4489_group_3
      WBPaper00025032:cluster_22
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027111:rde-3(r459)_downregulated
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_1
      WBPaper00032948:FedUp
      WBPaper00034739:N2moreDR1350
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00038060:SUMO-1_upregulated
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040426:CYE-1_CDK-2AF_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:nuo-6(qm200)_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00048989:N2_allantoin_upregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00055899:nitroguanidine_regulated
      [cgc5767]:cluster_7
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_ET
      [cgc5767]:expression_class_ET_max(101_min)
      [cgc5767]:expression_class_E_pi(53_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5767]:expression_class_MET
      [cgc6390]:oogenesis-enriched
    Interaction (112)
  Map_info: Map: III Position: 18.1911 Error: 0.01351
    Positive: Positive_clone: Y111B2A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene