| WBGene00004303 | SMap | S_parent | Sequence | C29E4 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | ran-2 |
| | | Sequence_name | C29E4.3 |
| | | Molecular_name | C29E4.3a |
| | | | C29E4.3a.1 |
| | | | CE37483 |
| | | | C29E4.3b |
| | | | CE30621 |
| | | | C29E4.3b.1 |
| | | | C29E4.3b.2 |
| | | Other_name | pna-3 | Person_evidence | WBPerson561 |
| | | | CELE_C29E4.3 | Accession_evidence | NDB | BX284603 |
| | | Public_name | ran-2 |
| | DB_info | Database | AceView | gene | 3J25 |
| | | | WormQTL | gene | WBGene00004303 |
| | | | WormFlux | gene | WBGene00004303 |
| | | | NDB | locus_tag | CELE_C29E4.3 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004303|UniProtKB=P34342 |
| | | | | family | PTHR24113 |
| | | | NCBI | gene | 176115 |
| | | | RefSeq | protein | NM_171884.5 |
| | | | | | NM_171198.8 |
| | | | SwissProt | UniProtAcc | P34342 |
| | | | TREEFAM | TREEFAM_ID | TF318283 |
| | | | UniProt_GCRP | UniProtAcc | P34342 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 06 Jul 2015 11:34:19 | WBPerson2970 | Event | Acquires_merge | WBGene00004067 |
| | | | | | | Name_change | Other_name | pna-3 |
| | | Acquires_merge | WBGene00004067 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ran |
| | Allele (51) |
| | Legacy_information | [Schnabel H] maternal effect embryonic lethal with abnormal pronuclear apppearance |
| | Strain | WBStrain00036599 |
| | | WBStrain00007779 |
| | | WBStrain00054780 |
| | RNASeq_FPKM (74) |
| | GO_annotation (13) |
| | Contained_in_operon | CEOP3465 |
| | Ortholog (47) |
| | Structured_description | Concise_description | ran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae. | Paper_evidence | WBPaper00004403 |
| | | | | | WBPaper00004651 |
| | | | | | WBPaper00005178 |
| | | | | | WBPaper00005637 |
| | | | | | WBPaper00011686 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Expressed in intestinal cell. Is an ortholog of human RANGAP1 (Ran GTPase activating protein 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C29E4.3a |
| | | C29E4.3b |
| | Corresponding_CDS_history | C29E4.3a:wp130 |
| | Corresponding_transcript | C29E4.3a.1 |
| | | C29E4.3b.1 |
| | | C29E4.3b.2 |
| | Other_sequence (24) |
| | Associated_feature | WBsf645370 |
| | | WBsf645371 |
| | | WBsf976236 |
| | | WBsf976237 |
| | | WBsf225302 |
| | | WBsf225303 |
| | | WBsf225304 |
| | | WBsf225305 |
| Experimental_info | RNAi_result | WBRNAi00085739 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062934 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062949 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001007 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00041448 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086891 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062955 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00002456 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00062942 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00065354 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr2038 |
| | | Expr1026981 |
| | | Expr1032128 |
| | | Expr1145479 |
| | | Expr2015251 |
| | | Expr2033485 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00032031:DConiospora_upregulated_cDNA_24h |
| | | WBPaper00035211:age-1_vs_N2_downregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00046303:P.aeruginosa_upregulated_protein |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031) |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050514:CEBP-1_interacting |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051265:F4_morc-1(tm6048)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053321:embryo-to-L1_upregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056443:sek-1(km4)_downregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_protein |
| | | WBPaper00059664:srbc-48(ac23)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00061340:DVC_parent |
| | | WBPaper00061340:Excretory_cell_parent |
| | | WBPaper00061340:M1_parent |
| | | WBPaper00061340:Parent_of_K_Kprime |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:HDA-1_interacting_protein |
| | | WBPaper00061527:lst-4_22151-F46F11.6_12556 |
| | | WBPaper00061527:mtr-4_1623-W03F9.10_103 |
| | | WBPaper00062123:GLH-1_interacting |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00063930:BRD-1_interacting |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065841:1_0 |
| | | WBPaper00065841:57_1 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_156 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00038231:Cry5B_1.5-fold_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00041002:HF_3d_2.0mM_Down |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00047070:N2_UV_upregulated |
| | | WBPaper00047070:xpa-1_UV_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (111) |
| Map_info | Map | III | Position | -0.48356 | Error | 0.002198 |
| | Positive | Positive_clone | C29E4 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (11) |
| Remark | Sequence connection from [Askjaer P, Mattaj IW]. krb 13/11/01 |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
