WormBase Tree Display for Gene: WBGene00004258
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| WBGene00004258 | SMap | S_parent | Sequence | D2023 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pyc-1 | Person_evidence | WBPerson184 | |||||
| Sequence_name | D2023.2 | ||||||||
| Molecular_name | D2023.2a | ||||||||
| D2023.2a.1 | |||||||||
| CE09072 | |||||||||
| D2023.2b | |||||||||
| CE46773 | |||||||||
| D2023.2a.2 | |||||||||
| D2023.2b.1 | |||||||||
| Other_name | CELE_D2023.2 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | pyc-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pyc | ||||||||
| Allele (66) | |||||||||
| Strain | WBStrain00054654 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00050970 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | |||||
| WBGene00004076 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00009319 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00012131 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017864 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | pyc-1 encodes the C. elegans pyruvate carboxylase ortholog; by homology, PYC-1 is predicted to function as a key regulatory enzyme of gluconeogenesis, lipogenesis, and anaplerosis, localizing to the mitochondrial matrix and catalyzing the formation of oxaloacetate from pyruvate and carbonate; pyc-1 expression is induced upon exposure of C. elegans to cadmium. | Paper_evidence | WBPaper00004992 | |||||
| WBPaper00005654 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Oct 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable pyruvate carboxylase activity. Predicted to be involved in gluconeogenesis and pyruvate metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Is an ortholog of human PC (pyruvate carboxylase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3651 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:8636) | ||||
| Disease_relevance | Mutations in human pyruvate carboxylase (PC) lead to pyruvate carboxylase deficiency, and are also associated with lactic acidemia, neurological abnormalities, and early death; in elegans, pyc-1, orthologous to PC, is a cadmium-responsive gene. | Homo sapiens | Paper_evidence | WBPaper00004992 | |||||
| Accession_evidence | OMIM | 266150 | |||||||
| 608786 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 03 Aug 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | D2023.2a | |||||||
| D2023.2b | |||||||||
| Corresponding_transcript | D2023.2a.1 | ||||||||
| D2023.2a.2 | |||||||||
| D2023.2b.1 | |||||||||
| Other_sequence (114) | |||||||||
| Associated_feature (19) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00043452 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00092274 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00111119 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092273 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012571 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030388 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1017480 | ||||||||
| Expr1032101 | |||||||||
| Expr1147446 | |||||||||
| Expr2015202 | |||||||||
| Expr2033436 | |||||||||
| Drives_construct | WBCnstr00035605 | ||||||||
| Construct_product | WBCnstr00035605 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction (66) | |||||||||
| Map_info | Map | V | Position | 3.38497 | Error | 0.002077 | |||
| Positive | Positive_clone | D2023 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | sequence connection from [Freedman JH] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
