WormBase Tree Display for Gene: WBGene00004244

WBGene00004244 SMap: S_parent: Sequence: C30G12
  Identity: Version: 2
    Name: CGC_name: puf-8 Person_evidence: WBPerson320
      Sequence_name: C30G12.7
      Molecular_name: C30G12.7
        C30G12.7.1
        CE37486
      Other_name: teg-2 Person_evidence: WBPerson555
        CELE_C30G12.7 Accession_evidence: NDB BX284602
      Public_name: puf-8
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 14 Aug 2012 14:38:21 WBPerson2970 Event: Acquires_merge: WBGene00006564
              Name_change: Other_name: teg-2
      Acquires_merge: WBGene00006564
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: puf
    Allele (42)
    Strain: WBStrain00022254
      WBStrain00022619
      WBStrain00022166
      WBStrain00022639
    RNASeq_FPKM (74)
    GO_annotation (13)
    Contained_in_operon: CEOP2292
    Ortholog (33)
    Paralog: WBGene00001401 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001402 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004239 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004241 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004242 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004243 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004245 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022257 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: puf-8 encodes a member of the PUF family of RNA binding proteins. Paper_evidence: WBPaper00042132
          Curator_confirmed: WBPerson1843
          Date_last_updated: 01 Apr 2014 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity. Involved in male meiotic nuclear division; negative regulation of MAPK cascade; and spermatogenesis. Located in P granule and nuclear periphery. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; germ line; sperm; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Is an ortholog of human PUM1 (pumilio RNA binding family member 1) and PUM2 (pumilio RNA binding family member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00061889
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Jun 2022 00:00:00
    Potential_model: DOID:0111743 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14957)
  Models_disease_in_annotation: WBDOannot00001263
  Molecular_info: Corresponding_CDS: C30G12.7
    Corresponding_CDS_history: C30G12.7:wp130
    Corresponding_transcript: C30G12.7.1
    Other_sequence: CR01371
      CRC02691_1
      CJC01330_1
    Associated_feature: WBsf019217
      WBsf019218
      WBsf223321
    Gene_product_binds: WBsf899537
      WBsf899538
      WBsf899539
      WBsf899540
  Experimental_info: RNAi_result (24)
    Expr_pattern (11)
    Drives_construct (12)
    Construct_product (9)
    Regulate_expr_cluster: WBPaper00045618:puf-8_downregulated
      WBPaper00045618:puf-8_upregulated
    Microarray_results (19)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00035269:cde-1_regulated
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00038118:aak-2(gt33)_upregulated
      WBPaper00042194:nhr-114(RNAi)_upregulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated
      WBPaper00045050:drh-3 (ne4253)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00048611:MnCl2_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPS_downregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050859:downregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:downregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:seam_enriched
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:stavudine_72h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:PGCs_enriched_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_upregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055103:thoc-5(wy822)_downregulated
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Allantoin_upregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056284:ints-5(RNAi)_downregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:spc-1(cas971)_upregulated
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058691:cfp-1(tm6369)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059254:CSR-1_interacting
      WBPaper00059254:PRG-1_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059598:HeatShock_downregulated
      WBPaper00059664:srbc-48(ac23)_downregulated
      WBPaper00060014:set-2(tm1630)_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061340:Germline
      WBPaper00061527:puf-3-oma-2_18268
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064005:starvation_downregulated_aptf-1(gk794)_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064716:paraquat_upregulated
      WBPaper00064769:him-17(me24)_downregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066110:Doxorubicin_downregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      WBPaper00025032:cluster_125
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00032165:A_to_C_transit_decreased
      WBPaper00032165:differentially_expressed_with_age_medoid_5
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_down_regulated
      WBPaper00036286:Pattern_B
      WBPaper00036429:glp-1(oz112)_upregulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040876:mir-35_upregulated
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00042128:gei-8(ok1671)_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
      WBPaper00051387:Triclosan_downregulated
      WBPaper00056330:mrps-5(RNAi)_downregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_6
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MD_pd(PC32)
      [cgc5767]:expression_class_SM
      [cgc5767]:expression_class_SMD
      [cgc6390]:oogenesis-enriched
    Interaction (43)
    WBProcess: WBbiopr:00000069
  Map_info: Map: II Position: 0.500136 Error: 0.000128
    Positive: Positive_clone: C30G12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4171
        4615
        5564
        3796
        3826
    Pseudo_map_position
  Reference (78)
  Remark: sequence connection from [Bernstein M, Wickens MP]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene