WormBase Tree Display for Gene: WBGene00004077
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| WBGene00004077 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_I | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pop-1 | Person_evidence | WBPerson498 | |||||
| Sequence_name | W10C8.2 | ||||||||
| Molecular_name | W10C8.2 | ||||||||
| W10C8.2.1 | |||||||||
| CE46967 | |||||||||
| Other_name | sys-2 | ||||||||
| CELE_W10C8.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | pop-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pop | ||||||||
| Allele (168) | |||||||||
| Legacy_information | [Lin R] Pop (posterior pharynx defective) phenotype: maternal lethal, causing MS blastomere to adopt the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. zu189 isolated in mutator background, probable Tc1 insertion. | ||||||||
| [C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells; MS blastomere adopts the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995; JJ] | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (114) | |||||||||
| Ortholog (59) | |||||||||
| Structured_description | Concise_description | pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva. | Paper_evidence | WBPaper00002330 | |||||
| WBPaper00004103 | |||||||||
| WBPaper00005116 | |||||||||
| WBPaper00024693 | |||||||||
| WBPaper00026603 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 04 Aug 2005 00:00:00 | ||||||||
| Automated_description | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including mesodermal cell fate commitment; regulation of cell division; and regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including ABplpapaaa; ABprpapaaa; oocyte; somatic nervous system; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including diabetes mellitus (multiple); endocrine gland cancer (multiple); and prostate disease (multiple). Is an ortholog of human TCF7L2 (transcription factor 7 like 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
| Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Jun 2022 00:00:00 | ||||||||
| Potential_model | DOID:9351 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | |||||
| DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||||
| DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||||
| DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||||
| DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) | ||||||
| DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) | ||||||
| DOID:8634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11639,HGNC:11641,HGNC:6551) | ||||||
| DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) | ||||||
| Models_disease_in_annotation | WBDOannot00001266 | ||||||||
| Molecular_info | Corresponding_CDS | W10C8.2 | |||||||
| Corresponding_CDS_history | W10C8.2:wp229 | ||||||||
| Corresponding_transcript | W10C8.2.1 | ||||||||
| Other_sequence (26) | |||||||||
| Associated_feature (14) | |||||||||
| Gene_product_binds (20) | |||||||||
| Transcription_factor | WBTranscriptionFactor000102 | ||||||||
| Experimental_info | RNAi_result (249) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00001895 | ||||||||
| WBCnstr00012848 | |||||||||
| WBCnstr00035711 | |||||||||
| Construct_product (13) | |||||||||
| Antibody | WBAntibody00000100 | ||||||||
| WBAntibody00000162 | |||||||||
| WBAntibody00000612 | |||||||||
| WBAntibody00000723 | |||||||||
| WBAntibody00000724 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (116) | |||||||||
| Interaction (464) | |||||||||
| Anatomy_function | WBbtf0106 | ||||||||
| WBProcess | WBbiopr:00000073 | ||||||||
| WBbiopr:00000112 | |||||||||
| WBbiopr:00000114 | |||||||||
| Map_info | Map | I | Position | -5.32204 | Error | 0.039261 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | BF8 | |||||||
| W10C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Negative_clone | K11A2 | |||||||
| Mapping_data | 2_point | 7005 | |||||||
| 7006 | |||||||||
| Multi_point | 3030 | ||||||||
| 4915 | |||||||||
| 5051 | |||||||||
| Pos_neg_data | 8160 | ||||||||
| 8161 | |||||||||
| 8162 | |||||||||
| 8163 | |||||||||
| 8164 | |||||||||
| 8165 | |||||||||
| 10668 | |||||||||
| 10669 | |||||||||
| Reference (328) | |||||||||
| Picture | WBPicture0000013083 | ||||||||
| WBPicture0000013084 | |||||||||
| Remark | Datum extracted from Lin et al. (1995). | ||||||||
| [Lin R] zu189 is Tc1 insertion allele, Tc1 mapped to BF8 + | |||||||||
| Sequence connection from [Lin R, Thompson S, Priess JR], [krb 020702] | |||||||||
| old_name sys-2 becomes new_name pop-1 from [Kimble JE]. | |||||||||
| Method | Gene |
