WormBase Tree Display for Gene: WBGene00004077

WBGene00004077 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: pop-1 Person_evidence: WBPerson498
      Sequence_name: W10C8.2
      Molecular_name: W10C8.2
        W10C8.2.1
        CE46967
      Other_name: sys-2
        CELE_W10C8.2 Accession_evidence: NDB BX284601
      Public_name: pop-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pop
    Allele (168)
    Legacy_information: [Lin R] Pop (posterior pharynx defective) phenotype: maternal lethal, causing MS blastomere to adopt the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. zu189 isolated in mutator background, probable Tc1 insertion.
      [C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells; MS blastomere adopts the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995; JJ]
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (113)
    Ortholog (59)
    Structured_description: Concise_description: pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva. Paper_evidence: WBPaper00002330
            WBPaper00004103
            WBPaper00005116
            WBPaper00024693
            WBPaper00026603
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 04 Aug 2005 00:00:00
      Automated_description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including mesodermal cell fate commitment; regulation of cell division; and regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including ABplpapaaa; ABprpapaaa; oocyte; somatic nervous system; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including diabetes mellitus (multiple); endocrine gland cancer (multiple); and prostate disease (multiple). Is an ortholog of human TCF7L2 (transcription factor 7 like 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00061889
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Jun 2022 00:00:00
    Potential_model: DOID:9351 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11641)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11641)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11641)
      DOID:11714 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11641)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6551)
      DOID:3969 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6551)
      DOID:8634 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6551)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11639,HGNC:11641,HGNC:6551)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11641)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11641)
  Models_disease_in_annotation: WBDOannot00001266
  Molecular_info: Corresponding_CDS: W10C8.2
    Corresponding_CDS_history: W10C8.2:wp229
    Corresponding_transcript: W10C8.2.1
    Other_sequence (26)
    Associated_feature (14)
    Gene_product_binds (20)
    Transcription_factor: WBTranscriptionFactor000102
  Experimental_info: RNAi_result (249)
    Expr_pattern (15)
    Drives_construct: WBCnstr00001895
      WBCnstr00012848
      WBCnstr00035711
    Construct_product (13)
    Antibody: WBAntibody00000100
      WBAntibody00000162
      WBAntibody00000612
      WBAntibody00000723
      WBAntibody00000724
    Microarray_results (22)
    Expression_cluster (116)
    Interaction: WBInteraction000000510
      WBInteraction000000711
      WBInteraction000000918
      WBInteraction000001728
      WBInteraction000002076
      WBInteraction000002365
      WBInteraction000002367
      WBInteraction000002368
      WBInteraction000002369
      WBInteraction000002373
      WBInteraction000002663
      WBInteraction000002713
      WBInteraction000002714
      WBInteraction000002876
      WBInteraction000002900
      WBInteraction000003158
      WBInteraction000003238
      WBInteraction000003239
      WBInteraction000003386
      WBInteraction000003608
      WBInteraction000003939
      WBInteraction000005227
      WBInteraction000005228
      WBInteraction000005229
      WBInteraction000005791
      WBInteraction000005792
      WBInteraction000005793
      WBInteraction000006409
      WBInteraction000006454
      WBInteraction000006494
      WBInteraction000006576
      WBInteraction000006686
      WBInteraction000006739
      WBInteraction000006902
      WBInteraction000006964
      WBInteraction000008889
      WBInteraction000009287
      WBInteraction000009402
      WBInteraction000009403
      WBInteraction000009577
      WBInteraction000009590
      WBInteraction000009794
      WBInteraction000009802
      WBInteraction000009876
      WBInteraction000009954
      WBInteraction000028285
      WBInteraction000028318
      WBInteraction000029838
      WBInteraction000031196
      WBInteraction000031523
      WBInteraction000031524
      WBInteraction000032641
      WBInteraction000032733
      WBInteraction000032887
      WBInteraction000033129
      WBInteraction000033194
      WBInteraction000033205
      WBInteraction000033889
      WBInteraction000034036
      WBInteraction000034310
      WBInteraction000034352
      WBInteraction000034394
      WBInteraction000034497
      WBInteraction000034540
      WBInteraction000036227
      WBInteraction000036552
      WBInteraction000036823
      WBInteraction000036932
      WBInteraction000037156
      WBInteraction000037252
      WBInteraction000037602
      WBInteraction000037603
      WBInteraction000037795
      WBInteraction000037819
      WBInteraction000037963
      WBInteraction000038183
      WBInteraction000038369
      WBInteraction000038482
      WBInteraction000038510
      WBInteraction000038865
      WBInteraction000039025
      WBInteraction000039515
      WBInteraction000040098
      WBInteraction000040109
      WBInteraction000040301
      WBInteraction000040695
      WBInteraction000040858
      WBInteraction000040938
      WBInteraction000040939
      WBInteraction000041311
      WBInteraction000041377
      WBInteraction000041392
      WBInteraction000041882
      WBInteraction000042102
      WBInteraction000043118
      WBInteraction000043314
      WBInteraction000043707
      WBInteraction000043750
      WBInteraction000043757
      WBInteraction000044015
      WBInteraction000044296
      WBInteraction000044411
      WBInteraction000045336
      WBInteraction000046127
      WBInteraction000046402
      WBInteraction000046840
      WBInteraction000047196
      WBInteraction000047197
      WBInteraction000047213
      WBInteraction000047281
      WBInteraction000047446
      WBInteraction000047447
      WBInteraction000047448
      WBInteraction000047711
      WBInteraction000048025
      WBInteraction000048111
      WBInteraction000048394
      WBInteraction000048574
      WBInteraction000048823
      WBInteraction000048983
      WBInteraction000049119
      WBInteraction000049901
      WBInteraction000049907
      WBInteraction000050018
      WBInteraction000050897
      WBInteraction000051373
      WBInteraction000051862
      WBInteraction000052704
      WBInteraction000117898
      WBInteraction000121234
      WBInteraction000121247
      WBInteraction000121260
      WBInteraction000122818
      WBInteraction000126350
      WBInteraction000126409
      WBInteraction000127111
      WBInteraction000127428
      WBInteraction000133290
      WBInteraction000133758
      WBInteraction000136019
      WBInteraction000136735
      WBInteraction000136770
      WBInteraction000142583
      WBInteraction000149058
      WBInteraction000150806
      WBInteraction000162249
      WBInteraction000165543
      WBInteraction000166069
      WBInteraction000166119
      WBInteraction000166183
      WBInteraction000166335
      WBInteraction000167073
      WBInteraction000167534
      WBInteraction000167543
      WBInteraction000170345
      WBInteraction000170346
      WBInteraction000172162
      WBInteraction000172958
      WBInteraction000173436
      WBInteraction000173801
      WBInteraction000193906
      WBInteraction000226244
      WBInteraction000271107
      WBInteraction000288707
      WBInteraction000305601
      WBInteraction000321908
      WBInteraction000339624
      WBInteraction000339872
      WBInteraction000392726
      WBInteraction000399936
      WBInteraction000452462
      WBInteraction000471094
      WBInteraction000472690
      WBInteraction000500010
      WBInteraction000500013
      WBInteraction000500017
      WBInteraction000500020
      WBInteraction000500225
      WBInteraction000500923
      WBInteraction000500925
      WBInteraction000501162
      WBInteraction000501163
      WBInteraction000501507
      WBInteraction000501867
      WBInteraction000501870
      WBInteraction000501975
      WBInteraction000501976
      WBInteraction000501977
      WBInteraction000501978
      WBInteraction000502029
      WBInteraction000502048
      WBInteraction000502049
      WBInteraction000502070
      WBInteraction000502113
      WBInteraction000502114
      WBInteraction000502151
      WBInteraction000502159
      WBInteraction000502161
      WBInteraction000502163
      WBInteraction000502164
      WBInteraction000502191
      WBInteraction000502229
      WBInteraction000502237
      WBInteraction000502315
      WBInteraction000502366
      WBInteraction000502367
      WBInteraction000502368
      WBInteraction000502369
      WBInteraction000502370
      WBInteraction000502404
      WBInteraction000502629
      WBInteraction000502632
      WBInteraction000503432
      WBInteraction000503655
      WBInteraction000503952
      WBInteraction000503966
      WBInteraction000504514
      WBInteraction000504515
      WBInteraction000504877
      WBInteraction000505407
      WBInteraction000505408
      WBInteraction000505409
      WBInteraction000505410
      WBInteraction000517643
      WBInteraction000517703
      WBInteraction000519237
      WBInteraction000519238
      WBInteraction000519243
      WBInteraction000519244
      WBInteraction000519245
      WBInteraction000519246
      WBInteraction000519247
      WBInteraction000519254
      WBInteraction000520180
      WBInteraction000520247
      WBInteraction000520248
      WBInteraction000521470
      WBInteraction000521664
      WBInteraction000521852
      WBInteraction000521876
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      WBInteraction000522243
      WBInteraction000522244
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      WBInteraction000522260
      WBInteraction000522261
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      WBInteraction000522267
      WBInteraction000522270
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      WBInteraction000522275
      WBInteraction000522276
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      WBInteraction000522283
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      WBInteraction000522286
      WBInteraction000522292
      WBInteraction000523964
      WBInteraction000523987
      WBInteraction000524214
      WBInteraction000524215
      WBInteraction000524216
      WBInteraction000524217
      WBInteraction000524218
      WBInteraction000524257
      WBInteraction000524645
      WBInteraction000524647
      WBInteraction000524808
      WBInteraction000524809
      WBInteraction000524810
      WBInteraction000524811
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      WBInteraction000524814
      WBInteraction000524815
      WBInteraction000524818
      WBInteraction000524819
      WBInteraction000524825
      WBInteraction000524826
      WBInteraction000524834
      WBInteraction000524835
      WBInteraction000524947
      WBInteraction000525401
      WBInteraction000525402
      WBInteraction000525895
      WBInteraction000526209
      WBInteraction000526332
      WBInteraction000526445
      WBInteraction000526555
      WBInteraction000526838
      WBInteraction000526933
      WBInteraction000527138
      WBInteraction000527139
      WBInteraction000527140
      WBInteraction000527141
      WBInteraction000527142
      WBInteraction000527143
      WBInteraction000527302
      WBInteraction000527360
      WBInteraction000527503
      WBInteraction000527574
      WBInteraction000527733
      WBInteraction000534857
      WBInteraction000534858
      WBInteraction000534860
      WBInteraction000534861
      WBInteraction000535396
      WBInteraction000538573
      WBInteraction000538587
      WBInteraction000538588
      WBInteraction000538589
      WBInteraction000538597
      WBInteraction000538598
      WBInteraction000538599
      WBInteraction000538600
      WBInteraction000538601
      WBInteraction000538621
      WBInteraction000538683
      WBInteraction000538696
      WBInteraction000538699
      WBInteraction000538700
      WBInteraction000538701
      WBInteraction000538702
      WBInteraction000541634
      WBInteraction000541744
      WBInteraction000541807
      WBInteraction000541825
      WBInteraction000541826
      WBInteraction000541835
      WBInteraction000541836
      WBInteraction000542020
      WBInteraction000542213
      WBInteraction000542214
      WBInteraction000542215
      WBInteraction000542216
      WBInteraction000542261
      WBInteraction000542262
      WBInteraction000542263
      WBInteraction000542267
      WBInteraction000542268
      WBInteraction000542269
      WBInteraction000542270
      WBInteraction000542271
      WBInteraction000542272
      WBInteraction000542292
      WBInteraction000542293
      WBInteraction000542294
      WBInteraction000542295
      WBInteraction000542296
      WBInteraction000542297
      WBInteraction000542298
      WBInteraction000542299
      WBInteraction000542300
      WBInteraction000542301
      WBInteraction000542339
      WBInteraction000542340
      WBInteraction000542341
      WBInteraction000542345
      WBInteraction000542346
      WBInteraction000542347
      WBInteraction000542709
      WBInteraction000542944
      WBInteraction000542945
      WBInteraction000542951
      WBInteraction000542952
      WBInteraction000543965
      WBInteraction000543966
      WBInteraction000543967
      WBInteraction000543968
      WBInteraction000543969
      WBInteraction000543970
      WBInteraction000543971
      WBInteraction000543972
      WBInteraction000543973
      WBInteraction000543974
      WBInteraction000543975
      WBInteraction000543976
      WBInteraction000543977
      WBInteraction000547296
      WBInteraction000547353
      WBInteraction000547474
      WBInteraction000547521
      WBInteraction000547529
      WBInteraction000547536
      WBInteraction000547680
      WBInteraction000547962
      WBInteraction000548033
      WBInteraction000548093
      WBInteraction000548500
      WBInteraction000548750
      WBInteraction000548751
      WBInteraction000548752
      WBInteraction000548753
      WBInteraction000548754
      WBInteraction000548755
      WBInteraction000548976
      WBInteraction000549462
      WBInteraction000555478
      WBInteraction000555605
      WBInteraction000555606
      WBInteraction000556523
      WBInteraction000556895
      WBInteraction000557515
      WBInteraction000557516
      WBInteraction000557518
      WBInteraction000557519
      WBInteraction000557520
      WBInteraction000557521
      WBInteraction000557661
      WBInteraction000557662
      WBInteraction000557663
      WBInteraction000557664
      WBInteraction000557665
      WBInteraction000557666
      WBInteraction000557667
      WBInteraction000557668
      WBInteraction000557669
      WBInteraction000557670
      WBInteraction000557671
      WBInteraction000557672
      WBInteraction000557673
      WBInteraction000557674
      WBInteraction000557675
      WBInteraction000557676
      WBInteraction000557677
      WBInteraction000557678
      WBInteraction000557679
      WBInteraction000557680
      WBInteraction000557681
      WBInteraction000557682
      WBInteraction000557683
      WBInteraction000557684
      WBInteraction000557685
      WBInteraction000557686
      WBInteraction000557687
      WBInteraction000557688
      WBInteraction000557689
      WBInteraction000557690
      WBInteraction000557691
      WBInteraction000557692
      WBInteraction000557693
      WBInteraction000557694
      WBInteraction000557695
      WBInteraction000557696
      WBInteraction000557697
      WBInteraction000557698
      WBInteraction000557699
      WBInteraction000557700
      WBInteraction000557701
      WBInteraction000557702
      WBInteraction000560439
      WBInteraction000560440
      WBInteraction000560441
      WBInteraction000560442
      WBInteraction000560443
      WBInteraction000560651
      WBInteraction000560652
      WBInteraction000569168
      WBInteraction000573316
      WBInteraction000586827
    Anatomy_function: WBbtf0106
    WBProcess: WBbiopr:00000073
      WBbiopr:00000112
      WBbiopr:00000114
  Map_info: Map: I Position: -5.32204 Error: 0.039261
    Well_ordered
    Positive: Positive_clone: BF8
        W10C8 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: K11A2
    Mapping_data: 2_point: 7005
        7006
      Multi_point: 3030
        4915
        5051
      Pos_neg_data: 8160
        8161
        8162
        8163
        8164
        8165
        10668
        10669
  Reference (328)
  Picture: WBPicture0000013083
    WBPicture0000013084
  Remark: Datum extracted from Lin et al. (1995).
    [Lin R] zu189 is Tc1 insertion allele, Tc1 mapped to BF8 +
    Sequence connection from [Lin R, Thompson S, Priess JR], [krb 020702]
    old_name sys-2 becomes new_name pop-1 from [Kimble JE].
  Method: Gene