WormBase Tree Display for Interaction: WBInteraction000502159
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| WBInteraction000502159 | Interaction_type | Regulatory | Change_of_expression_level | ||
|---|---|---|---|---|---|
| Interactor | Interactor_overlapping_gene | WBGene00001310 | Interactor_type | Trans_regulated | |
| Expr_pattern | Expr3502 | ||||
| Transgene | WBTransgene00004729 | ||||
| Construct | WBCnstr00004711 | ||||
| WBGene00004077 | Interactor_type | Trans_regulator | |||
| Variation_interactor | WBVar00275517 | Interactor_type | Trans_regulator | ||
| Interaction_summary | Depletion of POP-1 results in the derepression of E-specific gene end-1 in the MS blastomeres (MSa and MSp) and slight repression of end-1 in the Ea and Ep blastomeres. (Figure 1) | ||||
| Detection_method | Construct | ||||
| Reporter_gene | [end-1::gfp-H2B], translational fusion | ||||
| Transgene | |||||
| Regulation_level | Transcriptional | ||||
| Regulation_result | Positive_regulate | Anatomy_term | WBbt:0006612 | ||
| WBbt:0006733 | |||||
| Paper | WBPaper00026704 | ||||
| Remark | POP-1 represses E-specific genes, directly or indirectly, in the MS blastomere. Although similar GFP expression levels from the reporter transgene were observed in both MS and E lineages in pop-1 mutant embryos, these expression levels were significantly reduced when compared to the E-restricted expression levels in wild-type embryos. POP-1 not only represses the expression of E-specific genes in MS, but also plays a positive role in activating their expression in the E blastomere. In the absence of POP-1, these normally E-specific genes exhibit low, presumably basal, level expression in both MS and E. |
