WormBase Tree Display for Variation: WBVar00275517

WBVar00275517 Name: Public_name: zu189
  Sequence_details: SeqStatus: Pending_curation
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00022479
    Laboratory: JJ
    Status: Live
  Affects: Gene: WBGene00004077
    Interactor (25)
  Genetics: Mapping_data: In_2_point: 7005
        7006
      In_multi_point: 3030
      In_pos_neg_data: 8160
        8161
        8162
        8163
        8164
        8165
  Description: Phenotype (12)
    Phenotype_not_observed: WBPhenotype:0000306 Paper_evidence: WBPaper00003453
        Curator_confirmed: WBPerson2987
        Remark: Using the spicule SPD neuron-specific marker (gpa-1::lacZ), we found that pop-1(zu189) mutant males have a wild-type marker expression pattern in the spicules. Paper_evidence: WBPaper00003453
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0005831 PATO:0000460 Paper_evidence: WBPaper00003453
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Genotype: syIs20[gpa-1::lacZ+dpy-20(+)] (marker for male spicules and phasmid neurons) Paper_evidence: WBPaper00003453
              Curator_confirmed: WBPerson2987
      WBPhenotype:0000472 Paper_evidence: WBPaper00002871
        Curator_confirmed: WBPerson2987
        Remark: The pop-1(zu189) mutation does not result in embryos lacking endoderm (Table 1) Paper_evidence: WBPaper00002871
            Curator_confirmed: WBPerson2987
      WBPhenotype:0000760 Paper_evidence: WBPaper00003645
        Curator_confirmed: WBPerson2987
        Remark: In EMS cells derived from isolated P1 blastomeres from pop-1(zu189) mutants, spindles exhibited wild type orientation (Figure 2). Paper_evidence: WBPaper00003645
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006876 PATO:0000460 Paper_evidence: WBPaper00003645
                Curator_confirmed: WBPerson2987
          Life_stage: WBls:0000003 PATO:0000460 Paper_evidence: WBPaper00003645
                Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Authors isolated the smaller, posterior-most blastomere in a two-cell-stage embryo, called P1, and allowed it to divide into its daughters, P2 and EMS. The orientation of the mitotic spindle in EMS was then measured relative to the plane of contact between EMS and P2. Paper_evidence: WBPaper00003645
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001133 Paper_evidence: WBPaper00005375
        Curator_confirmed: WBPerson2987
        Remark: pop-1(zu189) animals exhibited no embryos with aberrant L-R division of EMS (Table 1) Paper_evidence: WBPaper00005375
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0006876 PATO:0000460 Paper_evidence: WBPaper00005375
                Curator_confirmed: WBPerson2987
      WBPhenotype:0001637 Paper_evidence: WBPaper00005375
        Curator_confirmed: WBPerson2987
        Remark: Table 1 Paper_evidence: WBPaper00005375
            Curator_confirmed: WBPerson2987
        EQ_annotations: Anatomy_term: WBbt:0005772 PATO:0000460 Paper_evidence: WBPaper00005375
                Curator_confirmed: WBPerson2987
  Reference (15)
  Method: Allele