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WormBase Tree Display for Gene: WBGene00004077

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Name Class

WBGene00004077EvidenceCGC_data_submission
SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameCGC_namepop-1Person_evidenceWBPerson498
Sequence_nameW10C8.2
Molecular_nameW10C8.2
W10C8.2.1
CE46967
Other_namesys-2
CELE_W10C8.2Accession_evidenceNDBBX284601
Public_namepop-1
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpop
Allele (168)
Legacy_information[Lin R] Pop (posterior pharynx defective) phenotype: maternal lethal, causing MS blastomere to adopt the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. zu189 isolated in mutator background, probable Tc1 insertion.
[C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells; MS blastomere adopts the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995; JJ]
Strain (11)
RNASeq_FPKM (74)
GO_annotation (113)
Ortholog (59)
Structured_descriptionConcise_descriptionpop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.Paper_evidenceWBPaper00002330
WBPaper00004103
WBPaper00005116
WBPaper00024693
WBPaper00026603
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated04 Aug 2005 00:00:00
Automated_descriptionEnables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including mesodermal cell fate commitment; regulation of cell division; and regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including ABplpapaaa; ABprpapaaa; oocyte; somatic nervous system; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including diabetes mellitus (multiple); endocrine gland cancer (multiple); and prostate disease (multiple). Is an ortholog of human TCF7L2 (transcription factor 7 like 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:9970Homo sapiensPaper_evidenceWBPaper00061889
Curator_confirmedWBPerson324
Date_last_updated28 Jun 2022 00:00:00
Potential_modelDOID:9351Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:11714Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:2394Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6551)
DOID:3969Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6551)
DOID:8634Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6551)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11639,HGNC:11641,HGNC:6551)
DOID:1793Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
DOID:1612Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11641)
Models_disease_in_annotationWBDOannot00001266
Molecular_infoCorresponding_CDSW10C8.2
Corresponding_CDS_historyW10C8.2:wp229
Corresponding_transcriptW10C8.2.1
Other_sequence (26)
Associated_feature (14)
Gene_product_binds (20)
Transcription_factorWBTranscriptionFactor000102
Experimental_infoRNAi_resultWBRNAi00101222Inferred_automaticallyRNAi_primary
WBRNAi00106758Inferred_automaticallyRNAi_primary
WBRNAi00100487Inferred_automaticallyRNAi_primary
WBRNAi00082746Inferred_automaticallyRNAi_primary
WBRNAi00084483Inferred_automaticallyRNAi_primary
WBRNAi00101439Inferred_automaticallyRNAi_primary
WBRNAi00061054Inferred_automaticallyRNAi_primary
WBRNAi00101809Inferred_automaticallyRNAi_primary
WBRNAi00098816Inferred_automaticallyRNAi_primary
WBRNAi00099956Inferred_automaticallyRNAi_primary
WBRNAi00101897Inferred_automaticallyRNAi_primary
WBRNAi00082761Inferred_automaticallyRNAi_primary
WBRNAi00067510Inferred_automaticallyRNAi_primary
WBRNAi00101467Inferred_automaticallyRNAi_primary
WBRNAi00081386Inferred_automaticallyRNAi_primary
WBRNAi00098998Inferred_automaticallyRNAi_primary
WBRNAi00104319Inferred_automaticallyRNAi_primary
WBRNAi00098929Inferred_automaticallyRNAi_primary
WBRNAi00101441Inferred_automaticallyRNAi_primary
WBRNAi00101505Inferred_automaticallyRNAi_primary
WBRNAi00082760Inferred_automaticallyRNAi_primary
WBRNAi00101749Inferred_automaticallyRNAi_primary
WBRNAi00082771Inferred_automaticallyRNAi_primary
WBRNAi00101820Inferred_automaticallyRNAi_primary
WBRNAi00091589Inferred_automaticallyRNAi_primary
WBRNAi00101927Inferred_automaticallyRNAi_primary
WBRNAi00091571Inferred_automaticallyRNAi_primary
WBRNAi00099007Inferred_automaticallyRNAi_primary
WBRNAi00098917Inferred_automaticallyRNAi_primary
WBRNAi00104308Inferred_automaticallyRNAi_primary
WBRNAi00063079Inferred_automaticallyRNAi_primary
WBRNAi00098999Inferred_automaticallyRNAi_primary
WBRNAi00099350Inferred_automaticallyRNAi_primary
WBRNAi00104317Inferred_automaticallyRNAi_primary
WBRNAi00101435Inferred_automaticallyRNAi_primary
WBRNAi00079066Inferred_automaticallyRNAi_primary
WBRNAi00098858Inferred_automaticallyRNAi_primary
WBRNAi00107663Inferred_automaticallyRNAi_primary
WBRNAi00101440Inferred_automaticallyRNAi_primary
WBRNAi00101241Inferred_automaticallyRNAi_primary
WBRNAi00104302Inferred_automaticallyRNAi_primary
WBRNAi00087097Inferred_automaticallyRNAi_primary
WBRNAi00104307Inferred_automaticallyRNAi_primary
WBRNAi00082776Inferred_automaticallyRNAi_primary
WBRNAi00087098Inferred_automaticallyRNAi_primary
WBRNAi00101365Inferred_automaticallyRNAi_primary
WBRNAi00114301Inferred_automaticallyRNAi_primary
WBRNAi00114104Inferred_automaticallyRNAi_primary
WBRNAi00082769Inferred_automaticallyRNAi_primary
WBRNAi00091596Inferred_automaticallyRNAi_primary
WBRNAi00079053Inferred_automaticallyRNAi_primary
WBRNAi00101373Inferred_automaticallyRNAi_primary
WBRNAi00084486Inferred_automaticallyRNAi_primary
WBRNAi00104321Inferred_automaticallyRNAi_primary
WBRNAi00083474Inferred_automaticallyRNAi_primary
WBRNAi00026469Inferred_automaticallyRNAi_primary
WBRNAi00082777Inferred_automaticallyRNAi_primary
WBRNAi00101920Inferred_automaticallyRNAi_primary
WBRNAi00083471Inferred_automaticallyRNAi_primary
WBRNAi00101879Inferred_automaticallyRNAi_primary
WBRNAi00092475Inferred_automaticallyRNAi_primary
WBRNAi00104304Inferred_automaticallyRNAi_primary
WBRNAi00065130Inferred_automaticallyRNAi_primary
WBRNAi00065129Inferred_automaticallyRNAi_primary
WBRNAi00104297Inferred_automaticallyRNAi_primary
WBRNAi00101527Inferred_automaticallyRNAi_primary
WBRNAi00101144Inferred_automaticallyRNAi_primary
WBRNAi00083472Inferred_automaticallyRNAi_primary
WBRNAi00101436Inferred_automaticallyRNAi_primary
WBRNAi00101391Inferred_automaticallyRNAi_primary
WBRNAi00104322Inferred_automaticallyRNAi_primary
WBRNAi00101992Inferred_automaticallyRNAi_primary
WBRNAi00101821Inferred_automaticallyRNAi_primary
WBRNAi00104298Inferred_automaticallyRNAi_primary
WBRNAi00098915Inferred_automaticallyRNAi_primary
WBRNAi00101525Inferred_automaticallyRNAi_primary
WBRNAi00104318Inferred_automaticallyRNAi_primary
WBRNAi00101048Inferred_automaticallyRNAi_primary
WBRNAi00067000Inferred_automaticallyRNAi_primary
WBRNAi00098918Inferred_automaticallyRNAi_primary
WBRNAi00101639Inferred_automaticallyRNAi_primary
WBRNAi00087096Inferred_automaticallyRNAi_primary
WBRNAi00069391Inferred_automaticallyRNAi_primary
WBRNAi00101443Inferred_automaticallyRNAi_primary
WBRNAi00080200Inferred_automaticallyRNAi_primary
WBRNAi00104309Inferred_automaticallyRNAi_primary
WBRNAi00104299Inferred_automaticallyRNAi_primary
WBRNAi00078680Inferred_automaticallyRNAi_primary
WBRNAi00101529Inferred_automaticallyRNAi_primary
WBRNAi00104301Inferred_automaticallyRNAi_primary
WBRNAi00100300Inferred_automaticallyRNAi_primary
WBRNAi00098859Inferred_automaticallyRNAi_primary
WBRNAi00082775Inferred_automaticallyRNAi_primary
WBRNAi00110450Inferred_automaticallyRNAi_primary
WBRNAi00061296Inferred_automaticallyRNAi_primary
WBRNAi00114066Inferred_automaticallyRNAi_primary
WBRNAi00082759Inferred_automaticallyRNAi_primary
WBRNAi00114224Inferred_automaticallyRNAi_primary
WBRNAi00069390Inferred_automaticallyRNAi_primary
WBRNAi00104320Inferred_automaticallyRNAi_primary
WBRNAi00101776Inferred_automaticallyRNAi_primary
WBRNAi00104316Inferred_automaticallyRNAi_primary
WBRNAi00067040Inferred_automaticallyRNAi_primary
WBRNAi00082772Inferred_automaticallyRNAi_primary
WBRNAi00092769Inferred_automaticallyRNAi_primary
WBRNAi00100113Inferred_automaticallyRNAi_primary
WBRNAi00114541Inferred_automaticallyRNAi_primary
WBRNAi00087877Inferred_automaticallyRNAi_primary
WBRNAi00101380Inferred_automaticallyRNAi_primary
WBRNAi00062634Inferred_automaticallyRNAi_primary
WBRNAi00114145Inferred_automaticallyRNAi_primary
WBRNAi00104303Inferred_automaticallyRNAi_primary
WBRNAi00101802Inferred_automaticallyRNAi_primary
WBRNAi00022993Inferred_automaticallyRNAi_primary
WBRNAi00101991Inferred_automaticallyRNAi_primary
WBRNAi00082773Inferred_automaticallyRNAi_primary
WBRNAi00101438Inferred_automaticallyRNAi_primary
WBRNAi00092556Inferred_automaticallyRNAi_primary
WBRNAi00103066Inferred_automaticallyRNAi_primary
WBRNAi00101808Inferred_automaticallyRNAi_primary
WBRNAi00117259Inferred_automaticallyRNAi_primary
WBRNAi00101797Inferred_automaticallyRNAi_primary
WBRNAi00099054Inferred_automaticallyRNAi_primary
WBRNAi00082770Inferred_automaticallyRNAi_primary
WBRNAi00101260Inferred_automaticallyRNAi_primary
WBRNAi00104311Inferred_automaticallyRNAi_primary
WBRNAi00084494Inferred_automaticallyRNAi_primary
WBRNAi00022992Inferred_automaticallyRNAi_primary
WBRNAi00087195Inferred_automaticallyRNAi_primary
WBRNAi00101364Inferred_automaticallyRNAi_primary
WBRNAi00087876Inferred_automaticallyRNAi_primary
WBRNAi00082752Inferred_automaticallyRNAi_primary
WBRNAi00099043Inferred_automaticallyRNAi_primary
WBRNAi00082768Inferred_automaticallyRNAi_primary
WBRNAi00098955Inferred_automaticallyRNAi_primary
WBRNAi00087873Inferred_automaticallyRNAi_primary
WBRNAi00101389Inferred_automaticallyRNAi_primary
WBRNAi00079048Inferred_automaticallyRNAi_primary
WBRNAi00082751Inferred_automaticallyRNAi_primary
WBRNAi00104305Inferred_automaticallyRNAi_primary
WBRNAi00077658Inferred_automaticallyRNAi_primary
WBRNAi00067122Inferred_automaticallyRNAi_primary
WBRNAi00084491Inferred_automaticallyRNAi_primary
WBRNAi00087157Inferred_automaticallyRNAi_primary
WBRNAi00104300Inferred_automaticallyRNAi_primary
WBRNAi00092552Inferred_automaticallyRNAi_primary
WBRNAi00055080Inferred_automaticallyRNAi_primary
WBRNAi00101626Inferred_automaticallyRNAi_primary
WBRNAi00101675Inferred_automaticallyRNAi_primary
WBRNAi00080201Inferred_automaticallyRNAi_primary
WBRNAi00107664Inferred_automaticallyRNAi_primary
WBRNAi00082763Inferred_automaticallyRNAi_primary
WBRNAi00066955Inferred_automaticallyRNAi_primary
WBRNAi00082767Inferred_automaticallyRNAi_primary
WBRNAi00098834Inferred_automaticallyRNAi_primary
WBRNAi00114723Inferred_automaticallyRNAi_primary
WBRNAi00101921Inferred_automaticallyRNAi_primary
WBRNAi00082758Inferred_automaticallyRNAi_primary
WBRNAi00082754Inferred_automaticallyRNAi_primary
WBRNAi00099552Inferred_automaticallyRNAi_primary
WBRNAi00114025Inferred_automaticallyRNAi_primary
WBRNAi00101629Inferred_automaticallyRNAi_primary
WBRNAi00067448Inferred_automaticallyRNAi_primary
WBRNAi00106885Inferred_automaticallyRNAi_primary
WBRNAi00101521Inferred_automaticallyRNAi_primary
WBRNAi00116677Inferred_automaticallyRNAi_primary
WBRNAi00092554Inferred_automaticallyRNAi_primary
WBRNAi00101649Inferred_automaticallyRNAi_primary
WBRNAi00099754Inferred_automaticallyRNAi_primary
WBRNAi00098916Inferred_automaticallyRNAi_primary
WBRNAi00114183Inferred_automaticallyRNAi_primary
WBRNAi00104296Inferred_automaticallyRNAi_primary
WBRNAi00098931Inferred_automaticallyRNAi_primary
WBRNAi00082750Inferred_automaticallyRNAi_primary
WBRNAi00104315Inferred_automaticallyRNAi_primary
WBRNAi00087870Inferred_automaticallyRNAi_primary
WBRNAi00101523Inferred_automaticallyRNAi_primary
WBRNAi00061057Inferred_automaticallyRNAi_primary
WBRNAi00107662Inferred_automaticallyRNAi_primary
WBRNAi00101747Inferred_automaticallyRNAi_primary
WBRNAi00101924Inferred_automaticallyRNAi_primary
WBRNAi00091564Inferred_automaticallyRNAi_primary
WBRNAi00101437Inferred_automaticallyRNAi_primary
WBRNAi00098964Inferred_automaticallyRNAi_primary
WBRNAi00079049Inferred_automaticallyRNAi_primary
WBRNAi00101387Inferred_automaticallyRNAi_primary
WBRNAi00101442Inferred_automaticallyRNAi_primary
WBRNAi00082757Inferred_automaticallyRNAi_primary
WBRNAi00104310Inferred_automaticallyRNAi_primary
WBRNAi00082765Inferred_automaticallyRNAi_primary
WBRNAi00073315Inferred_automaticallyRNAi_primary
WBRNAi00082747Inferred_automaticallyRNAi_primary
WBRNAi00082774Inferred_automaticallyRNAi_primary
WBRNAi00101458Inferred_automaticallyRNAi_primary
WBRNAi00091582Inferred_automaticallyRNAi_primary
WBRNAi00098832Inferred_automaticallyRNAi_primary
WBRNAi00101665Inferred_automaticallyRNAi_primary
WBRNAi00106595Inferred_automaticallyRNAi_primary
WBRNAi00106719Inferred_automaticallyRNAi_primary
WBRNAi00082756Inferred_automaticallyRNAi_primary
WBRNAi00114260Inferred_automaticallyRNAi_primary
WBRNAi00082764Inferred_automaticallyRNAi_primary
WBRNAi00101659Inferred_automaticallyRNAi_primary
WBRNAi00104314Inferred_automaticallyRNAi_primary
WBRNAi00101367Inferred_automaticallyRNAi_primary
WBRNAi00103065Inferred_automaticallyRNAi_primary
WBRNAi00101609Inferred_automaticallyRNAi_primary
WBRNAi00082755Inferred_automaticallyRNAi_primary
WBRNAi00101211Inferred_automaticallyRNAi_primary
WBRNAi00101878Inferred_automaticallyRNAi_primary
WBRNAi00092770Inferred_automaticallyRNAi_primary
WBRNAi00073317Inferred_automaticallyRNAi_primary
WBRNAi00101662Inferred_automaticallyRNAi_primary
WBRNAi00103064Inferred_automaticallyRNAi_primary
WBRNAi00101381Inferred_automaticallyRNAi_primary
WBRNAi00099055Inferred_automaticallyRNAi_primary
WBRNAi00092553Inferred_automaticallyRNAi_primary
WBRNAi00101519Inferred_automaticallyRNAi_primary
WBRNAi00091581Inferred_automaticallyRNAi_primary
WBRNAi00100674Inferred_automaticallyRNAi_primary
WBRNAi00101371Inferred_automaticallyRNAi_primary
WBRNAi00082748Inferred_automaticallyRNAi_primary
WBRNAi00100861Inferred_automaticallyRNAi_primary
WBRNAi00000109Inferred_automaticallyRNAi_primary
WBRNAi00087099Inferred_automaticallyRNAi_primary
WBRNAi00082749Inferred_automaticallyRNAi_primary
WBRNAi00026468Inferred_automaticallyRNAi_primary
WBRNAi00067285Inferred_automaticallyRNAi_primary
WBRNAi00104313Inferred_automaticallyRNAi_primary
WBRNAi00099006Inferred_automaticallyRNAi_primary
WBRNAi00082211Inferred_automaticallyRNAi_primary
WBRNAi00027738Inferred_automaticallyRNAi_primary
WBRNAi00106565Inferred_automaticallyRNAi_primary
WBRNAi00106750Inferred_automaticallyRNAi_primary
WBRNAi00101925Inferred_automaticallyRNAi_primary
WBRNAi00104312Inferred_automaticallyRNAi_primary
WBRNAi00082766Inferred_automaticallyRNAi_primary
WBRNAi00073316Inferred_automaticallyRNAi_primary
WBRNAi00092476Inferred_automaticallyRNAi_primary
WBRNAi00084482Inferred_automaticallyRNAi_primary
WBRNAi00067232Inferred_automaticallyRNAi_primary
WBRNAi00091583Inferred_automaticallyRNAi_primary
WBRNAi00101279Inferred_automaticallyRNAi_primary
WBRNAi00101457Inferred_automaticallyRNAi_primary
WBRNAi00104306Inferred_automaticallyRNAi_primary
WBRNAi00082753Inferred_automaticallyRNAi_primary
WBRNAi00099044Inferred_automaticallyRNAi_primary
WBRNAi00085638Inferred_automaticallyRNAi_primary
WBRNAi00101369Inferred_automaticallyRNAi_primary
Expr_pattern (15)
Drives_constructWBCnstr00001895
WBCnstr00012848
WBCnstr00035711
Construct_product (13)
AntibodyWBAntibody00000100
WBAntibody00000162
WBAntibody00000612
WBAntibody00000723
WBAntibody00000724
Microarray_results (22)
Expression_cluster (116)
Interaction (464)
Anatomy_functionWBbtf0106
WBProcessWBbiopr:00000073
WBbiopr:00000112
WBbiopr:00000114
Map_infoMapIPosition-5.32204Error0.039261
Well_ordered
PositivePositive_cloneBF8
W10C8Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeNegative_cloneK11A2
Mapping_data2_point7005
7006
Multi_point3030
4915
5051
Pos_neg_data8160
8161
8162
8163
8164
8165
10668
10669
Reference (328)
PictureWBPicture0000013083
WBPicture0000013084
RemarkDatum extracted from Lin et al. (1995).
[Lin R] zu189 is Tc1 insertion allele, Tc1 mapped to BF8 +
Sequence connection from [Lin R, Thompson S, Priess JR], [krb 020702]
old_name sys-2 becomes new_name pop-1 from [Kimble JE].
MethodGene